Research & Publications
Obesity related insulin resistance as primary health risk factors for type 2 diabetes and cardiovascular disease are a main research focus to date. Skeletal muscle plays a dominant role in glucose control. One goal is has been to develop an exercise challenge model to exploit muscle glucose metabolism in healthy overweight/obese young people with the intent of providing an early warning system for health risk. Most recently, growing interest in the potential role of brown adipose tissue in obesity has led to current research using mild cold exposure in combination with special imaging techniques to explore a new method to examine the role of autonomic nervous system activation of brown adipose tissue in humans. In addition, using a classic autonomic nervous system challenge, the cold pressor test, helps to magnify potential cardiovascular risk associated with drinking water containing low-to-moderate levels of inorganic arsenic. This work conducted in rural Romania also has led to investigation of inter-individual differences in human inorganic arsenic metabolism with respect to patterns of retention or excretion. Collaborative work is ongoing in the area of nutrient sensing pathways: Roles of taste, digestion, and brain processing contributions to ingestive behavior.
Specialized Terms: Obesity; Insulin resistance; Exercise physiology and metabolism;Metabolic Syndrome; Autonomic Nervous System; Inorganic arsenic metabolism; Cardiovascular risk
Extensive Research Description
- Maximal exercise recovery as a model for insulin resistance and beta-cell function.
- Mild cold and PET-imaging to examine the norepinephine reuptake transporter in human brown adipose tissue
- Cardiovascular risk from exposure to inorganic arsenic in drinking water
- Inter-individual differences in inorganic arsenic metabolic partitioning and low birth weight outcome.
- Collaboration (animal model): Integration nutrient sensing pathways
Autonomic Nervous System; Adipose Tissue, Brown; Diabetes Mellitus, Type 2; Insulin Resistance; Obesity; Romania; Metabolic Syndrome
Public Health Interests
Cardiovascular Diseases; Nutrition; Obesity
- Glycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 DiabetesELSHAFIE A, LAM W, PARIKH L, RANGEL E, SCHMIDT C, HWANG J, YECKEL C, SHERWIN R, BELFORT-DEAGUIAR R. Glycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 Diabetes Diabetes 2018, 67 DOI: 10.2337/db18-82-lb.
- Skeletal Muscle Nonnutritive Blood Flow Increases in Response to a Sit‐to‐Stand Orthostatic ChallengeYeckel C, Castillo M, Gosselin M, Gulanski B. Skeletal Muscle Nonnutritive Blood Flow Increases in Response to a Sit‐to‐Stand Orthostatic Challenge The FASEB Journal 2011, 25: 814.12-814.12. DOI: 10.1096/fasebj.25.1_supplement.814.12.
- Progressive Improvement in Glucose Tolerance with Light Resistance TVaining in Older WomenDiPietro L, Yeckel C, Dziura J. Progressive Improvement in Glucose Tolerance with Light Resistance TVaining in Older Women Medicine & Science In Sports & Exercise 2007, 39: s288. DOI: 10.1249/01.mss.0000274112.76453.98.
- Maximal exercise recovery as a potential means for assessing sympathetic overactivity related to insulin resistanceYeckel C, Gulanski B, Lopes M, Dziura J, Parish R, Sherwin R. Maximal exercise recovery as a potential means for assessing sympathetic overactivity related to insulin resistance The FASEB Journal 2007, 21: a575-a575. DOI: 10.1096/fasebj.21.5.a575.
- Exercise and Improved Insulin Sensitivity in Older Women: Evidence of the Enduring Benefits of Higher Intensity Training.DiPietro L, Dziura J, Yeckel C, Neufer P. Exercise and Improved Insulin Sensitivity in Older Women: Evidence of the Enduring Benefits of Higher Intensity Training. Cardiopulmonary Physical Therapy Journal 2006, 17: 95. DOI: 10.1097/01823246-200617020-00011.
- Obesity and the Metabolic Syndrome in Children and AdolescentsWeiss R, Dziura J, Burgert T, Tamborlane W, Taksali S, Yeckel C, Allen K, Lopes M, Savoye M, Morrison J, Sherwin R, Caprio S. Obesity and the Metabolic Syndrome in Children and Adolescents Obstetrical & Gynecological Survey 2004, 59: 822-824. DOI: 10.1097/01.ogx.0000140472.10719.95.
- Fatty Acid OxidationMorio B, Yeckel C, Wolfe R. Fatty Acid Oxidation 2003 DOI: 10.1038/npg.els.0000633.
- GENDER DIFFERENCES IN FATTY ACID AVAILABILITY DURING MODERATE INTENSITY EXERCISEYeckel C, Durham W, Sheffield-Moore M, Chinkes D, Wolf S, Miller S, Wolfe R. GENDER DIFFERENCES IN FATTY ACID AVAILABILITY DURING MODERATE INTENSITY EXERCISE Medicine & Science In Sports & Exercise 2002, 34: s260. DOI: 10.1097/00005768-200205001-01453.
- BLOOD FLOW EFFECTS ON GLUCOSE UPTAKE FOLLOWING RESISTANCE EXERCISEDurham W, Yeckel C, Ozkan O, Miller S, Tipton K, Rasmussen B, Wolf S, Walser E, Arsland A, Wolfe R. BLOOD FLOW EFFECTS ON GLUCOSE UPTAKE FOLLOWING RESISTANCE EXERCISE Medicine & Science In Sports & Exercise 2001, 33: s329. DOI: 10.1097/00005768-200105001-01848.
- EFFECT OF BLOOD FLOW ON POST-EXERCISE MUSCLE PROTEIN SYNTHESISDurham W, Miller S, Yeckel C, Tipton K, Rasmussen B, Walser E, Wolfe R. EFFECT OF BLOOD FLOW ON POST-EXERCISE MUSCLE PROTEIN SYNTHESIS Medicine & Science In Sports & Exercise 1999, 31: s279. DOI: 10.1097/00005768-199905001-01366.