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Bubu Banini, MD, PhD

Assistant Professor of Medicine (Digestive Diseases); Translational Research Director of the Metabolic Health and Weight Loss Program, Digestive Diseases

Research Summary

My research interests are in the pathophysiology and treatment of steatohepatitis in the context of alcohol associated and nonalcoholic fatty liver disease. I am also interested in obesity research, especially in the context of nonalcoholic fatty liver disease. I currently serve as the Translational Research Director of the Metabolic Health and Weight Management Program.

Coauthors

Research Interests

Clinical Trials as Topic; Fatty Liver, Alcoholic; Obesity; Non-alcoholic Fatty Liver Disease; Health Disparity, Minority and Vulnerable Populations

Selected Publications

  • 318 – Haptoglobin 2 Allele is Associated with Increased Risk and Severity of Alcoholic HepatitisBanini B, Chalasani N, Liang T, Liu W, Liu Z, Le P, Mirshahi F, Shah V, Sanyal A. 318 – Haptoglobin 2 Allele is Associated with Increased Risk and Severity of Alcoholic Hepatitis Gastroenterology 2019, 156: s-1191. DOI: 10.1016/s0016-5085(19)39952-4.
  • Vitamin E in Nonalcoholic Fatty Liver DiseaseBanini B, Sanyal A. Vitamin E in Nonalcoholic Fatty Liver Disease 2019, 311-323. DOI: 10.1007/978-3-030-05315-4_23.
  • THU-295-Non-alcoholic fatty liver disease is associated with QTc lengthening in the general populationBanini B, Issa D, Seneshaw M, Siddiqui M, Oseini A, Mirshahi F, Dessie S, Puri P, Aneni E, Blaha M, Budoff M, Rifai M, Szklo M, Nasir K, Sanyal A. THU-295-Non-alcoholic fatty liver disease is associated with QTc lengthening in the general population Journal Of Hepatology 2019, 70: e290. DOI: 10.1016/s0618-8278(19)30558-4.
  • Vitamin E in nonalcoholic fatty liver disease. In Vitamin E in Human HealthBanini BA, Sanyal AJ. Vitamin E in nonalcoholic fatty liver disease. In Vitamin E in Human Health. Peter Weber and Manfred Eggersdorfer, Editors. Springer 2019.
  • Enlarging Ectopic Thyroid in the Porta HepatisBanini B, Matherly S, Lee H. Enlarging Ectopic Thyroid in the Porta Hepatis The American Journal Of Gastroenterology 2018, 113: s1356. DOI: 10.14309/00000434-201810001-02433.
  • Coagulopathy: Pathophysiology, Evaluation, and TreatmentBanini B, Sanyal A. Coagulopathy: Pathophysiology, Evaluation, and Treatment 2018, 173-193. DOI: 10.1007/978-3-319-64298-7_15.
  • PS-049 Acceleration of NASH in a mouse model provides novel insights on the mechanisms by which I148M PNPLA3 drives steatohepatitisBanini B, Cazanave S, Min H, Kumar D, Santhekadur P, Wang L, Guan H, Seneshaw M, Bedossa P, Oseini A, Mirshahi F, Alonso C, Koduru S, Sanyal A. PS-049 Acceleration of NASH in a mouse model provides novel insights on the mechanisms by which I148M PNPLA3 drives steatohepatitis Journal Of Hepatology 2018, 68: s28. DOI: 10.1016/s0168-8278(18)30274-5.
  • SAT-503 Collagen formation and degradation biomarkers identify advanced fibrosis in NASH patientsLuo Y, Charles E, Vincent R, Gagnon R, Oseini A, Banini B, Mirshahi F, Daita K, Christian R, Sanyal A. SAT-503 Collagen formation and degradation biomarkers identify advanced fibrosis in NASH patients Journal Of Hepatology 2017, 66: s676-s677. DOI: 10.1016/s0168-8278(17)31824-x.
  • THU-367 Key molecular signatures of disease development and progression in non-alcoholic fatty liver disease in humansVincent R, Nefedov A, Oseini A, Cazanave S, Webber A, Jensen K, Tanis K, Wang L, Banini B, Kumar D, Min H, Santhekadur P, Seneshaw M, Daita K, Bedossa P, Mirshahi F, Sanyal A. THU-367 Key molecular signatures of disease development and progression in non-alcoholic fatty liver disease in humans Journal Of Hepatology 2017, 66: s162. DOI: 10.1016/s0168-8278(17)30598-6.
  • Nonalcoholic Steatohepatitis (NASH) Has Surpassed Hepatitis C as the Leading Etiology for Listing for Liver Transplant: Implications for NASH in Children and Young AdultsBanini B, Mota M, Behnke M, Sharma A, Sanyal A. Nonalcoholic Steatohepatitis (NASH) Has Surpassed Hepatitis C as the Leading Etiology for Listing for Liver Transplant: Implications for NASH in Children and Young Adults The American Journal Of Gastroenterology 2016, 111: s339. DOI: 10.14309/00000434-201610001-00755.
  • Transient Elastography Use in the Assessment of Cirrhosis in Patients with Non-Alcoholic SteatohepatitisMota M, Banini B, Siddiqui M, Sanyal A. Transient Elastography Use in the Assessment of Cirrhosis in Patients with Non-Alcoholic Steatohepatitis The American Journal Of Gastroenterology 2016, 111: s449. DOI: 10.14309/00000434-201610001-01030.
  • SAT-333 Omega-3 Carboxylic Acids, Epanova®, and the Sodium-Glucose Co-Transporter 2 Inhibitor, Dapagliflozin®, Improve Steatohepatitis and Fibrosis Scoring in a Mouse Model of Non-Alcoholic SteatohepatitisCazanave S, Banini B, Asgharpour A, Vincent R, Seneshaw M, Kumar D, Mirshahi F, Daita K, Puri P, Oscarsson J, Bedossa P, Sanyal A. SAT-333 Omega-3 Carboxylic Acids, Epanova®, and the Sodium-Glucose Co-Transporter 2 Inhibitor, Dapagliflozin®, Improve Steatohepatitis and Fibrosis Scoring in a Mouse Model of Non-Alcoholic Steatohepatitis Journal Of Hepatology 2016, 64: s685. DOI: 10.1016/s0168-8278(16)01303-9.
  • Hepatocellular CarcinomaBanini B, Roberts L. Hepatocellular Carcinoma 2015, 207-218. DOI: 10.1007/978-3-319-13614-1_22.
  • Hepatocellular carcinoma. In Complications of Cirrhosis: Evaluation and Management.Banini BA and Roberts LR. Hepatocellular carcinoma. In Complications of Cirrhosis: Evaluation and Management. Keaveny A and Cardenas A, Editors. Springer 2015.
  • 53 EARLY EXPOSURE TO BUTYRATE INCREASES FETAL HEMOGLOBIN DURING ADULT ERYTHROID DEVELOPMENT IN VITRO.Banini B, Addya S, Delgrosso K, Keller M, Surrey S. 53 EARLY EXPOSURE TO BUTYRATE INCREASES FETAL HEMOGLOBIN DURING ADULT ERYTHROID DEVELOPMENT IN VITRO. Journal Of Investigative Medicine 2006, 54: s352. DOI: 10.2310/6650.2005.x0015.52.
  • Early Exposure to Butyrate Increases Fetal Hemoglobin during Adult Erythroid Development in VitroBanini B, Addya S, Delgrosso K, Keller M, Surrey S. Early Exposure to Butyrate Increases Fetal Hemoglobin during Adult Erythroid Development in Vitro Journal Of Investigative Medicine 2006, 54: 352-352. DOI: 10.1177/108155890605402s53.
  • Transcriptome Analysis of Human Hematopoietic Progenitor Cells during In Vitro Erythroid Differentiation.Keller M, Addya S, Vadigepalli R, Ponte C, Banini B, Delgrosso K, Surrey S. Transcriptome Analysis of Human Hematopoietic Progenitor Cells during In Vitro Erythroid Differentiation. Blood 2005, 106: 1750-1750. DOI: 10.1182/blood.v106.11.1750.1750.

Clinical Trials

ConditionsStudy Title
Diseases of the Digestive System - LiverA Phase 2b Study in Subjects With Alcoholic Hepatitis to Evaluate Safety and Efficacy of DUR-928 Treatment (AHFIRM)
Hepatitis; Diseases of the Digestive System - LiverDigoxin In Alcohol Associated Hepatitis