2008
A PDZ‐Binding Motif Controls Basolateral Targeting of Syndecan‐1 Along the Biosynthetic Pathway in Polarized Epithelial Cells
Maday S, Anderson E, Chang HC, Shorter J, Satoh A, Sfakianos J, Fölsch H, Anderson JM, Walther Z, Mellman I. A PDZ‐Binding Motif Controls Basolateral Targeting of Syndecan‐1 Along the Biosynthetic Pathway in Polarized Epithelial Cells. Traffic 2008, 9: 1915-1924. PMID: 18764819, PMCID: PMC2820280, DOI: 10.1111/j.1600-0854.2008.00805.x.Peer-Reviewed Original ResearchConceptsPolarized epithelial cellsBiosynthetic pathwayPDZ domain-containing proteinsType II PDZDomain-containing proteinsPDZ-Binding MotifSyndecan-1Cell surface proteoglycansEpithelial cellsBasolateral targetingNormal epithelial morphologyBasolateral domainMotif leadPlasma membranePDZBasolateral localizationSurface proteoglycansBasolateral surfaceApical surfaceEpithelial morphologyMotifPotential rolePathwayCellsMislocalization
2000
hCASK and hDlg Associate in Epithelia, and Their Src Homology 3 and Guanylate Kinase Domains Participate in Both Intramolecular and Intermolecular Interactions*
Nix S, Chishti A, Anderson J, Walther Z. hCASK and hDlg Associate in Epithelia, and Their Src Homology 3 and Guanylate Kinase Domains Participate in Both Intramolecular and Intermolecular Interactions*. Journal Of Biological Chemistry 2000, 275: 41192-41200. PMID: 10993877, DOI: 10.1074/jbc.m002078200.Peer-Reviewed Original ResearchConceptsHuman CASKGUK domainGuanylate kinasePlasma membraneSrc homology 3 domainSrc homology 3Two-hybrid assayGuanylate kinase domainBasolateral plasma membraneTwo-hybridHomology 3Protein binding assaysMAGUK proteinsMultiprotein complexesSH3 domainHuman p55Kinase domainScaffold assemblyIntestinal cell lineMAGUKsHDlgHEK293 cellsImmunofluorescence microscopyIntramolecular bindingSpecialized regions