William Chang, MD, PhD
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Appointments
Nephrology
Primary
Contact Info
About
Titles
Assistant Professor of Medicine (Nephrology)
Appointments
Nephrology
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Nephrology Fellow
- Yale University (2012)
- Resident
- Yale New Haven Hospital (2008)
- Intern
- Yale New Haven Hospital (2007)
- PhD
- New York University, Oncology and Immunology (2006)
- MD
- New York University School of Medicine (2006)
- AB
- Harvard, Biology (1998)
Research
Overview
Medical Subject Headings (MeSH)
Biotechnology; Cell Biology; Kidney; Organoids
ORCID
0000-0002-7707-9242
Research at a Glance
Yale Co-Authors
Frequent collaborators of William Chang's published research.
Publications Timeline
A big-picture view of William Chang's research output by year.
Jordan Pober, MD, PhD
Alfred Bothwell, PhD
Diane Krause, MD, PhD
Francesc Lopez-Giraldez, PhD
Lawrence Young, MD
Lin Wang, MS
21Publications
1,567Citations
Publications
2020
Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro
Kosyakova N, Kao DD, Figetakis M, López-Giráldez F, Spindler S, Graham M, James KJ, Won Shin J, Liu X, Tietjen GT, Pober JS, Chang WG. Differential functional roles of fibroblasts and pericytes in the formation of tissue-engineered microvascular networks in vitro. Npj Regenerative Medicine 2020, 5: 1. PMID: 31934351, PMCID: PMC6944695, DOI: 10.1038/s41536-019-0086-3.Peer-Reviewed Original ResearchCitationsAltmetric
2019
NSAID associated bilateral renal infarctions: a case report
Jeon Y, Lis JB, Chang WG. NSAID associated bilateral renal infarctions: a case report. International Journal Of Nephrology And Renovascular Disease 2019, 12: 177-181. PMID: 31447577, PMCID: PMC6682756, DOI: 10.2147/ijnrd.s212010.Peer-Reviewed Original ResearchCitationsAltmetricConceptsNon-steroidal anti-inflammatory drugsRenal infarctionAnti-inflammatory drugsHigh-dose non-steroidal anti-inflammatory drugsRenal arterial blood flowBilateral renal infarctionYear old womanArterial blood flowPresence of NSAIDsNSAID useRenovascular vasoconstrictionRenal injuryVasoconstrictive effectRenal perfusionCase reportHigh prevalenceOlder womenBlood flowInfarctionCausative agentDrugsHypoperfusionVasoconstrictionPatientsInjury- Chang WG. (2019). Tools for Kidney Tissue Engineering: Bioreactor Systems, Scaffolds, and Cell Sources. In R. L. Reis, & M. E. Gomes (Eds.), Encyclopedia of Tissue Engineering and Regenerative Medicine, Vol. 1 (pp. 199–208). Academic Press: Elsevier.Books
2017
A short discourse on vascular tissue engineering
Chang WG, Niklason LE. A short discourse on vascular tissue engineering. Npj Regenerative Medicine 2017, 2: 7. PMID: 29057097, PMCID: PMC5649630, DOI: 10.1038/s41536-017-0011-6.BooksCitationsAltmetric
2016
ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction
Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y. ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction. JCI Insight 2016, 1: e80920. PMID: 27525311, PMCID: PMC4982472, DOI: 10.1172/jci.insight.80920.Peer-Reviewed Original ResearchCitationsConceptsMyocardial infarctionControl animalsCardiovascular progenitor cellsProgenitor cellsVentricular contractile functionCardiac repair strategiesNew blood vesselsInfarct areaLineage-tracing studiesContractile functionCardiac repairBlood vessel formationMyocardial regenerationEndothelial cellsHeart tissueBlood vesselsMurine heartInfarctionVessel formationInjuryMiceDelivery approachCardiomyocytesHeartCellsBlocking MHC class II on human endothelium mitigates acute rejection
Abrahimi P, Qin L, Chang WG, Bothwell AL, Tellides G, Saltzman WM, Pober JS. Blocking MHC class II on human endothelium mitigates acute rejection. JCI Insight 2016, 1: e85293. PMID: 26900601, PMCID: PMC4756651, DOI: 10.1172/jci.insight.85293.Peer-Reviewed Original ResearchCitationsAltmetricConceptsClass II MHC moleculesCytotoxic T lymphocytesII MHC moleculesClass I MHC moleculesMHC moleculesI MHC moleculesEndothelial cellsAcute rejectionT cellsEffector memory T cellsT cell-mediated destructionAcute allograft rejectionCell-mediated destructionGraft endothelial cellsMemory T cellsAlloreactive cytotoxic T lymphocytesExperimental rodent modelsMajor histocompatibility complex moleculesSecondary lymphoid organsMHC class IIClass I major histocompatibility complex moleculesAllogeneic human lymphocytesHistocompatibility complex moleculesPrevents CD4Artery graft
2015
Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli
Chang WG, Fornoni A, Tietjen G, Mendez JJ, Niklason LE, Saltzman WM, Pober JS. Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli. Tissue Engineering Part A 2015, 21: 2673-2679. PMID: 26414101, PMCID: PMC4652181, DOI: 10.1089/ten.tea.2015.0060.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsEfficient Gene Disruption in Cultured Primary Human Endothelial Cells by CRISPR/Cas9
Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman WM, Pober JS. Efficient Gene Disruption in Cultured Primary Human Endothelial Cells by CRISPR/Cas9. Circulation Research 2015, 117: 121-128. PMID: 25940550, PMCID: PMC4490936, DOI: 10.1161/circresaha.117.306290.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCell SeparationCells, CulturedCRISPR-Cas SystemsEndothelial Progenitor CellsFemaleFetal BloodGene DeletionGene Knockout TechniquesGenes, MHC Class IIGenetic VectorsHLA-DR AntigensHumansIntracellular Signaling Peptides and ProteinsLentivirusLymphocyte ActivationLymphocyte Culture Test, MixedMiceMice, SCIDNuclear ProteinsPrimary Cell CultureProteinsTetracyclineTrans-ActivatorsVesicular Transport Proteins
2013
Sustained delivery of proangiogenic microRNA‐132 by nanoparticle transfection improves endothelial cell transplantation
Devalliere J, Chang WG, Andrejecsk JW, Abrahimi P, Cheng CJ, Jane‐wit D, Saltzman WM, Pober JS. Sustained delivery of proangiogenic microRNA‐132 by nanoparticle transfection improves endothelial cell transplantation. The FASEB Journal 2013, 28: 908-922. PMID: 24221087, PMCID: PMC3898640, DOI: 10.1096/fj.13-238527.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHuman umbilical vein ECsEndothelial cellsMiR-132MicroRNA-132Cultured human umbilical vein endothelial cellsNumber of microvesselsGrowth factor-induced proliferationHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsEndothelial cell transplantationCultured endothelial cellsEndogenous growth factorsEC transplantationVein endothelial cellsCell transplantationImmunodeficient miceTissue perfusionTransplantationMiR deliveryGrowth factorIntegrin αvβ3Endocytosed nanoparticlesSquare millimeterBiological effectsControl transfectionPericytes modulate endothelial sprouting
Chang WG, Andrejecsk JW, Kluger MS, Saltzman WM, Pober JS. Pericytes modulate endothelial sprouting. Cardiovascular Research 2013, 100: 492-500. PMID: 24042014, PMCID: PMC3826704, DOI: 10.1093/cvr/cvt215.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsBecaplerminCoculture TechniquesCulture Media, ConditionedHepatocyte Growth FactorHuman Umbilical Vein Endothelial CellsHumansMicrovesselsNeovascularization, PhysiologicParacrine CommunicationPericytesProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-sisSignal TransductionSpheroids, CellularTime FactorsTransfectionVascular Endothelial Growth Factor A
Academic Achievements and Community Involvement
activity Member
Professional OrganizationsAmerican Society of NephrologyDetails2008 - Presenthonor Kidney X: Artificial Kidney Prize
National AwardASN and HHSDetails06/12/2023United Statesactivity Engineering Bioartificial Kidneys: Combining Kidney Organoids and Peritoneal Dialysis
Oral PresentationKidney X SummitDetails06/12/2023 - 06/12/2023Washington, DC, United Statesactivity Reviewer
Journal ServiceSCIENTIFIC REPORTSDetails2022 - 2022DescriptionAD HOC REVIEWERactivity Reviewer
Journal ServiceJOURNAL OF CLINICAL INVESTIGATIONDetails2022 - 2022DescriptionAD HOC REVIEWER
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