2012
Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING
Holm CK, Jensen SB, Jakobsen MR, Cheshenko N, Horan KA, Moeller HB, Gonzalez-Dosal R, Rasmussen SB, Christensen MH, Yarovinsky TO, Rixon FJ, Herold BC, Fitzgerald KA, Paludan SR. Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING. Nature Immunology 2012, 13: 737-743. PMID: 22706339, PMCID: PMC3411909, DOI: 10.1038/ni.2350.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell FusionChemokine CXCL10HEK293 CellsHeLa CellsHerpesvirus 1, HumanHumansImmunity, InnateInterferon Type ILeukocytesLymphocyte ActivationMacrophagesMembrane FusionMembrane GlycoproteinsMembrane ProteinsMiceMice, KnockoutMyeloid Differentiation Factor 88Signal TransductionToll-Like Receptor 7Toll-Like Receptor 9Virus Internalization
2006
Early Exposure to IL-4 Stabilizes IL-4 mRNA in CD4+ T Cells via RNA-Binding Protein HuR
Yarovinsky TO, Butler NS, Monick MM, Hunninghake GW. Early Exposure to IL-4 Stabilizes IL-4 mRNA in CD4+ T Cells via RNA-Binding Protein HuR. The Journal Of Immunology 2006, 177: 4426-4435. PMID: 16982877, DOI: 10.4049/jimmunol.177.7.4426.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBase SequenceCD4-Positive T-LymphocytesELAV ProteinsELAV-Like Protein 1Electrophoretic Mobility Shift AssayFlow CytometryFluorescent Antibody TechniqueGene ExpressionGene Expression RegulationImmunoblottingInterleukin-4Lymphocyte ActivationMiceMicroscopy, ConfocalMolecular Sequence DataProtein Structure, SecondaryRNA StabilityRNA, MessengerRNA-Binding Proteins
2001
Lung fibroblasts inhibit activation-induced death of T cells through PGE2-dependent mechanisms
Yarovinsky T, Hunninghake G. Lung fibroblasts inhibit activation-induced death of T cells through PGE2-dependent mechanisms. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2001, 281: l1248-l1256. PMID: 11597917, DOI: 10.1152/ajplung.2001.281.5.l1248.Peer-Reviewed Original ResearchConceptsActivation-induced cell deathFibroblast-conditioned mediumT cellsLung fibroblastsFas/Fas ligand-dependent mechanismFas ligand-dependent mechanismMouse primary lung fibroblastsPGE2-dependent mechanismsImmobilized anti-CD3 antibodyAnti-CD3 antibodyActivation-induced deathPrimary lung fibroblastsLigand-dependent mechanismTreatment of fibroblastsCaspase-3Fas receptorAntiapoptotic activityIndomethacinCell deathInhibitory activityFibroblastsDeathFibroblast culturesCaspase-8Cells