Seth Guller, PhD
Senior Research Scientist in Obstetrics, Gynecology, and Reproductive SciencesDownloadHi-Res Photo
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Director, Gyn/Endocrine Laboratory
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Obstetrics, Gynecology & Reproductive Sciences
333 Cedar Street
New Haven, CT 06510-
United States
Appointments
Additional Titles
Director, Gyn/Endocrine Laboratory
Contact Info
Obstetrics, Gynecology & Reproductive Sciences
333 Cedar Street
New Haven, CT 06510-
United States
Appointments
Additional Titles
Director, Gyn/Endocrine Laboratory
Contact Info
Obstetrics, Gynecology & Reproductive Sciences
333 Cedar Street
New Haven, CT 06510-
United States
About
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Titles
Senior Research Scientist in Obstetrics, Gynecology, and Reproductive Sciences
Director, Gyn/Endocrine Laboratory
Biography
Dr. Seth Guller, trained as a biochemist, joined the Yale Fertility Center as Director of the Reproductive Endocrinology Laboratory in 2007. The function of this clinical laboratory is to provide rapid hormone analysis for patients as well as test results for research studies. Dr. Guller strives to implement new tests for the recently acquired Roche Cobas e411 analyzer to improve the quality of patient care. He has also directed a research laboratory for the last 21 years. Dr. Guller has published more than 75 peer-reviewed papers.
Last Updated on February 24, 2025.
Appointments
Obstetrics, Gynecology & Reproductive Sciences
Senior Research ScientistPrimary
Other Departments & Organizations
- Discovery to Cure Internship
- Fertility Center
- Guller Lab
- Obstetrics, Gynecology & Reproductive Sciences
- Perinatal Research
- Reproductive Endocrinology & Infertility
- Reproductive Sciences
Education & Training
- PhD
- Mount Sinai School of Medicine (1986)
Research
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Overview
Medical Research Interests
Gynecology; Obstetrics; Placenta Diseases; Pre-Eclampsia; Pregnancy Outcome
ORCID
0000-0003-0651-8241
Research at a Glance
Yale Co-Authors
Frequent collaborators of Seth Guller's published research.
Publications Timeline
A big-picture view of Seth Guller's research output by year.
Research Interests
Research topics Seth Guller is interested in exploring.
Charles Lockwood, MD
Harvey Kliman, MD, PhD
Vikki M Abrahams, PhD
Zhonghua Tang
Erol Fikrig, MD
Liubin Yang, MD, PhD, FACOG
82Publications
5,565Citations
Pre-Eclampsia
Placenta Diseases
Pregnancy Outcome
Publications
2025
Distinct transcriptional and epigenomic programs define Hofbauer cells in term placenta
Baráth B, Bojcsuk D, Bene K, Caballero-Sánchez N, Cseh T, de Freitas J, Tzerpos P, Toth M, Tang Z, Guller S, Krasznai Z, Neuperger P, Szebeni G, Nagy G, Deli T, Nagy L. Distinct transcriptional and epigenomic programs define Hofbauer cells in term placenta. JCI Insight 2025, 11: e195801. PMID: 41433105, PMCID: PMC12892902, DOI: 10.1172/jci.insight.195801.Peer-Reviewed Original ResearchCitationsAltmetricRole of Serotonin on Gene Expression and Physiology in Human Cytotrophoblasts and Placenta
Morris N, Guller S, Tang Z, Zhang Y, Siegman E, Milano K, Rudnick G, Kliman H. Role of Serotonin on Gene Expression and Physiology in Human Cytotrophoblasts and Placenta. Endocrinology 2025, 166: bqaf124. PMID: 40898405, PMCID: PMC12399332, DOI: 10.1210/endocr/bqaf124.Peer-Reviewed Original ResearchThis study investigates how serotonin affects placental gene expression and growth, showing its critical role in embryonic development via nuclear protein modification called serotonylation.
2023
Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis
Ozmen A, Nwabuobi C, Tang Z, Guo X, Larsen K, Guller S, Blas J, Moore M, Kayisli U, Lockwood C, Guzeloglu-Kayisli O. Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis. International Journal Of Molecular Sciences 2023, 25: 135. PMID: 38203306, PMCID: PMC10778808, DOI: 10.3390/ijms25010135.Peer-Reviewed Original ResearchCitations
2022
Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity
Anam AK, Cooke KM, Dratver MB, O'Bryan JV, Perley LE, Guller SM, Hwang JJ, Taylor HS, Goedeke L, Kliman HJ, Vatner DF, Flannery CA. Insulin increases placental triglyceride as a potential mechanism for fetal adiposity in maternal obesity. Molecular Metabolism 2022, 64: 101574. PMID: 35970449, PMCID: PMC9440306, DOI: 10.1016/j.molmet.2022.101574.Peer-Reviewed Original ResearchCitationsAltmetric
2021
YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion
Feliciano D, Ott CM, Espinosa-Medina I, Weigel AV, Benedetti L, Milano KM, Tang Z, Lee T, Kliman HJ, Guller SM, Lippincott-Schwartz J. YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion. Nature Communications 2021, 12: 4502. PMID: 34301937, PMCID: PMC8302681, DOI: 10.1038/s41467-021-24708-2.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAdaptor Proteins, Signal TransducingAMP-Activated Protein KinasesAnimalsBiological TransportCell FusionCell LineCell Line, TumorCell MembraneCell NucleusCells, CulturedGiant CellsHEK293 CellsHumansMembrane GlycoproteinsMiceRNA-SeqSignal TransductionTranscription FactorsTranscription, GeneticViral Envelope ProteinsYAP-Signaling ProteinsMaternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface
Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Team Y, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Med 2021, 2: 591-610.e10. PMID: 33969332, PMCID: PMC8084634, DOI: 10.1016/j.medj.2021.04.016.Peer-Reviewed Original ResearchCitationsAltmetric
2020
Acetaminophen Attenuates invasion and alters the expression of extracellular matrix enzymes and vascular factors in human first trimester trophoblast cells
Burman A, Garcia-Milian R, Wood M, DeWitt NA, Vasiliou V, Guller S, Abrahams VM, Whirledge S. Acetaminophen Attenuates invasion and alters the expression of extracellular matrix enzymes and vascular factors in human first trimester trophoblast cells. Placenta 2020, 104: 146-160. PMID: 33348283, DOI: 10.1016/j.placenta.2020.12.002.Peer-Reviewed Original ResearchCitationsAltmetricZika Virus-Infected Decidual Cells Elicit a Gestational Age-Dependent Innate Immune Response and Exaggerate Trophoblast Zika Permissiveness: Implication for Vertical Transmission.
Guzeloglu-Kayisli O, Guo X, Tang Z, Semerci N, Ozmen A, Larsen K, Mutluay D, Guller S, Schatz F, Kayisli UA, Lockwood CJ. Zika Virus-Infected Decidual Cells Elicit a Gestational Age-Dependent Innate Immune Response and Exaggerate Trophoblast Zika Permissiveness: Implication for Vertical Transmission. The Journal Of Immunology 2020, 205: 3083-3094. PMID: 33139490, DOI: 10.4049/jimmunol.2000713.Peer-Reviewed Original ResearchCitationsAltmetricPeri‐implantation cytokine profile differs between singleton and twin IVF pregnancies
Simpson S, Kaislasuo J, Peng G, Aldo P, Paidas M, Guller S, Mor G, Pal L. Peri‐implantation cytokine profile differs between singleton and twin IVF pregnancies. American Journal Of Reproductive Immunology 2020, 85: e13348-e13348. PMID: 32946159, PMCID: PMC8221280, DOI: 10.1111/aji.13348.Peer-Reviewed Original ResearchCitationsNLRP3 inflammasome function and pyroptotic cell death in human placental Hofbauer cells
Abrahams VM, Tang Z, Mor G, Guller S. NLRP3 inflammasome function and pyroptotic cell death in human placental Hofbauer cells. Journal Of Reproductive Immunology 2020, 142: 103214. PMID: 33152658, PMCID: PMC7770077, DOI: 10.1016/j.jri.2020.103214.Peer-Reviewed Original ResearchCitationsAltmetric
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Obstetrics, Gynecology & Reproductive Sciences
333 Cedar Street
New Haven, CT 06510-
United States