Vikki M Abrahams, PhD
Professor, Obstetrics, Gynecology & Reproductive SciencesCards
Appointments
Additional Titles
Director, Division of Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences
Co-Vice Chair of Faculty Development, Department of Obstetrics, Gynecology & Reproductive Sciences
Contact Info
Appointments
Additional Titles
Director, Division of Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences
Co-Vice Chair of Faculty Development, Department of Obstetrics, Gynecology & Reproductive Sciences
Contact Info
Appointments
Additional Titles
Director, Division of Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences
Co-Vice Chair of Faculty Development, Department of Obstetrics, Gynecology & Reproductive Sciences
Contact Info
About
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Titles
Professor, Obstetrics, Gynecology & Reproductive Sciences
Director, Division of Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences; Co-Vice Chair of Faculty Development, Department of Obstetrics, Gynecology & Reproductive Sciences
Biography
Dr Vikki Abrahams is a Professor, Director of the Division of Reproductive Sciences and Co-Vice Chair of Faculty Development in the Department of Obstetrics, Gynecology and Reproductive Sciences.
Dr Abrahams received her B.Sc. (hons) in Immunology in 1996, and was awarded a Ph.D. in Immunology in 2000, both from University College London. She continued her studies as a postdoctoral associate at Dartmouth Medical School and then at Yale University in the field of Reproductive Immunology. In 2004 she joined the faculty in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine.
Dr Abrahams' research focuses on understanding the role of innate immune Toll-like receptor and Nod-like receptor family members in placental and maternal-fetal immune responses, and their role in regulating pregnancy outcome, including those complicated by infections and by autoimmune diseases. Studies from the Abrahams laboratory has characterized the mechanisms by which Toll-like receptors, Nod-like receptors, and the inflammasome function in the placental trophoblast and fetal membranes in response to both infectious and non-infectious stimuli.
Dr Abrahams is a member of the American Association of Immunologists, International Society for Immunology of Reproduction, Society for Reproductive Investigation, and the American Society of Reproductive Immunology. Dr Abrahams is the Associate Editor for Reviews of the American Journal of Reproductive Immunology and also serves on the editorial boards for a number of other journals within the Reproductive Sciences field.
Appointments
Obstetrics, Gynecology & Reproductive Sciences
ProfessorPrimary
Other Departments & Organizations
- Abrahams Lab
- Discovery to Cure Internship
- Human and Translational Immunology Program
- Obstetrics, Gynecology & Reproductive Sciences
- Perinatal Research
- Reproductive Sciences
- Yale WRHR Advisory Committee
Education & Training
- PhD
- University College (2000)
Research
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Overview
Medical Research Interests
ORCID
0000-0003-4995-1061
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Hanah Georges, PhD
Mancy Tong, PhD
Seth Guller, PhD
Crina Boeras
Alyssa Ann Grimshaw, MBA, MLIS, MPH
Kimberly Yonkers, MD
Antibodies, Antiphospholipid
Inflammasomes
Antiphospholipid Syndrome
MicroRNAs
Placenta
Toll-Like Receptors
Publications
2026
Viral dsRNA triggers human fetal membrane miR-146a-3p to be packaged into small extracellular vesicles which in turn drives inflammation through activation of Toll-like Receptor 7 and 8
Georges H, Fischer A, Casanova P, Abrahams V. Viral dsRNA triggers human fetal membrane miR-146a-3p to be packaged into small extracellular vesicles which in turn drives inflammation through activation of Toll-like Receptor 7 and 8. PLOS ONE 2026, 21: e0350139. PMID: 42189811, PMCID: PMC13210296, DOI: 10.1371/journal.pone.0350139.Peer-Reviewed Original ResearchCorrigendum to “Antiphospholipid-exposed trophoblast-derived extracellular vesicles express elevated levels of TLR7/8-activating microRNAs and induce endometrial endothelial activation, in part, in part, through TLR7” [J. Reprod. Immunol. 164 (2024) 104255]
Coenen C, Hidalgo T, Lynn T, Jones D, Salmon J, Chamley L, Abrahams V. Corrigendum to “Antiphospholipid-exposed trophoblast-derived extracellular vesicles express elevated levels of TLR7/8-activating microRNAs and induce endometrial endothelial activation, in part, in part, through TLR7” [J. Reprod. Immunol. 164 (2024) 104255]. Journal Of Reproductive Immunology 2026, 173: 104843. PMID: 41577568, DOI: 10.1016/j.jri.2026.104843.Commentaries, Editorials and LettersNicotinamide Riboside Mitigates Antiphospholipid Antibody‐Induced Dysfunction in Human Trophoblast Cells
Fischer A, Georges H, Jones D, Chamley L, Abrahams V. Nicotinamide Riboside Mitigates Antiphospholipid Antibody‐Induced Dysfunction in Human Trophoblast Cells. American Journal Of Reproductive Immunology 2026, 95: e70205. PMID: 41527285, DOI: 10.1111/aji.70205.Peer-Reviewed Original ResearchAltmetric
2025
A role for TLR7 activation by miR-146a-3p in antiphospholipid antibody-induced trophoblast IL-8 and inflammasome-mediated IL-1β production
Salmeron L, Hidalgo T, Lynn T, Jones D, Chamley L, Abrahams V. A role for TLR7 activation by miR-146a-3p in antiphospholipid antibody-induced trophoblast IL-8 and inflammasome-mediated IL-1β production. Journal Of Reproductive Immunology 2025, 172: 104652. PMID: 41014738, DOI: 10.1016/j.jri.2025.104652.Peer-Reviewed Original ResearchCitationsIntermediate Signaling Mechanisms Regulating Human Fetal Membrane Responses to Gram‐Positive Bacterial Peptidoglycan
Georges H, Fischer A, Abrahams V. Intermediate Signaling Mechanisms Regulating Human Fetal Membrane Responses to Gram‐Positive Bacterial Peptidoglycan. American Journal Of Reproductive Immunology 2025, 93: e70090-e70090. PMID: 40435036, PMCID: PMC12124414, DOI: 10.1111/aji.70090.Peer-Reviewed Original ResearchCitationsBuprenorphine induces human fetal membrane sterile inflammation
Lynn T, Kelleher M, Georges H, McCauley E, Logan R, Yonkers K, Abrahams V. Buprenorphine induces human fetal membrane sterile inflammation. Journal Of Reproductive Immunology 2025, 168: 104445. PMID: 39914058, PMCID: PMC11890952, DOI: 10.1016/j.jri.2025.104445.Peer-Reviewed Original ResearchCitationsAltmetric
2024
Predictors of Inflammation-Mediated Preterm Birth
Georges H, Norwitz E, Abrahams V. Predictors of Inflammation-Mediated Preterm Birth. Physiology 2024, 40: 26-36. PMID: 39106300, PMCID: PMC11918307, DOI: 10.1152/physiol.00022.2024.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricAntiphospholipid-exposed trophoblast-derived extracellular vesicles express elevated levels of TLR7/8-activating microRNAs and induce endometrial endothelial activation, in part, through TLR7
Coenen C, Hidalgo T, Lynn T, Jones D, Salmon J, Chamley L, Abrahams V. Antiphospholipid-exposed trophoblast-derived extracellular vesicles express elevated levels of TLR7/8-activating microRNAs and induce endometrial endothelial activation, in part, through TLR7. Journal Of Reproductive Immunology 2024, 164: 104255. PMID: 38797133, DOI: 10.1016/j.jri.2024.104255.Peer-Reviewed Original ResearchCitationsTLR8‐activating miR‐146a‐3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS
Georges H, Cassin C, Tong M, Abrahams V. TLR8‐activating miR‐146a‐3p is an intermediate signal contributing to fetal membrane inflammation in response to bacterial LPS. Immunology 2024, 172: 577-587. PMID: 38631842, PMCID: PMC11223956, DOI: 10.1111/imm.13794.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBα
Tong M, Scott J, Whirledge S, Abrahams V. Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating IκBα. Journal Of Reproductive Immunology 2023, 159: 103988. PMID: 37451159, PMCID: PMC10530124, DOI: 10.1016/j.jri.2023.103988.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Activities
activity American Society for Reproductive Immunology
05/01/2000 - PresentProfessional OrganizationsMemberactivity American Association of Immunologists
2009 - PresentProfessional OrganizationsMemberactivity Associate Editor for Reviews for the American Journal of Reproductive Immunology
07/01/2010 - PresentCommitteesMemberactivity Editorial Board for the Journal of Reproductive Immunology
07/01/2006 - PresentCommitteesMemberactivity The International Society for Immunology of Reproduction
07/01/2011 - PresentProfessional OrganizationsMember
Honors
honor American Journal of Reproductive Immunology Award
06/15/2019National AwardAmerican Society for Reproductive ImmunologyDetailsUnited Stateshonor NIH Senior Lectureship
09/02/2017International AwardInternational Federation of Placental AssociationsDetailsUnited Kingdomhonor J. Christian Herr Award for Excellence in Reproductive Immunology Research
06/01/2013National AwardAmerican Society for Reproductive ImmunologyDetailsUnited Stateshonor The Harold Behrman Award for mentoring students, residents and fellows
06/03/2011Yale School of Medicine AwardDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale UniversityDetailsUnited States
News & Links
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News
- February 11, 2025
Why Opioid Use Disorder (OUD) May Contribute to Preterm Birth
- May 16, 2023
Women’s Health Research at Yale Funds Studies to Improve Early Detection of Ovarian Cancer, Treatment of Prenatal Infections, and Aortic Aneurysm Outcomes in Women
- April 13, 2023
Research Adds Insights Into Preeclampsia, a Deadly Pregnancy Complication
- December 14, 2022Source: Yale News
Inflammation May Explain Antidepressants’ Link to Preterm Birth
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