2010
Targeted therapy for thyroid cancer: An updated review of investigational agents.
Deshpande HA, Gettinger SN, Sosa JA. Targeted therapy for thyroid cancer: An updated review of investigational agents. Current Opinion In Investigational Drugs 2010, 11: 661-8. PMID: 20496261.Peer-Reviewed Original ResearchConceptsMedullary thyroid cancerThyroid cancerEarly phase clinical trialsPapillary thyroid cancerRandomized trialsInvestigational agentsClinical trialsTargeted therapyPotential therapyPromising drugXL-184CancerTreatmentUpdated reviewTherapyTrialsMolecular mechanismsSunitinibMalignancySorafenibVandetanibBRAFVEGFRCarcinogenesis
2009
Axitinib: The evidence of its potential in the treatment of advanced thyroid cancer
Deshpande HA, Gettinger S, Sosa JA. Axitinib: The evidence of its potential in the treatment of advanced thyroid cancer. Core Evidence 2009, Volume 4: 43-48. PMID: 20694064, PMCID: PMC2899774, DOI: 10.2147/ce.s5996.Peer-Reviewed Original ResearchThyroid cancerVascular endothelial growth factor receptor 1Common grade 3Refractory thyroid cancerUse of axitinibGood tolerability profilePhase II studyAdvanced thyroid cancerGrowth factor receptor 1Greater side effectsFactor receptor 1Growth factor receptorStable diseaseTolerability profileII studyHistological typeCancer deathGrade 3New small molecule inhibitorsRare diseaseSide effectsSmall molecule inhibitorsResponse rateNew treatmentsReceptor 1
2008
Novel chemotherapy options for advanced thyroid tumors: small molecules offer great hope
Deshpande HA, Gettinger SN, Sosa JA. Novel chemotherapy options for advanced thyroid tumors: small molecules offer great hope. Current Opinion In Oncology 2008, 20: 19-24. PMID: 18043252, DOI: 10.1097/cco.0b013e3282f28373.Peer-Reviewed Original ResearchConceptsThyroid cancerClinical trialsAdvanced thyroid tumorsAdvanced thyroid cancerFurther clinical trialsMedullary thyroid cancerRandomized clinical trialsAblative radiation therapyEpidermal growth factor receptorInhibitors of angiogenesisGrowth factor receptorChemotherapy optionsMedical oncologistsEndocrine tumorsConventional chemotherapyRET inhibitionEndocrine cancersEndocrine malignancyRadiation therapyThyroid tumorsAntiangiogenesis strategiesNatural historyCancerFactor receptorRET protein