Scott Gettinger, MD
Professor of Internal Medicine (Medical Oncology)DownloadHi-Res Photo
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Chief, Thoracic Medical Oncology
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View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
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Chief, Thoracic Medical Oncology
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Chief, Thoracic Medical Oncology
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About
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Titles
Professor of Internal Medicine (Medical Oncology)
Chief, Thoracic Medical Oncology
Biography
Dr. Gettinger is internationally recognized for his expertise in lung cancer treatment and research. He is best known for his work in immunotherapy and targeted therapy for non-small cell lung cancer. He currently leads several clinical trials evaluating novel therapies for patients with lung cancer. His primary translational research interests include understanding mechanisms of sensitivity and resistance to molecularly targeted therapies and immunotherapies.
Last Updated on April 07, 2025.
Appointments
Medical Oncology and Hematology
ProfessorPrimary
Other Departments & Organizations
- Center for Thoracic Cancers
- Developmental Therapeutics
- Internal Medicine
- Medical Oncology and Hematology
- SPORE in Lung Cancer
- Yale Cancer Center
- Yale Medicine
- Yale New Haven Health System
- Yale Ventures
Education & Training
- Fellow
- Beth Israel Medical Center, NY (2005)
- Resident
- Beth Israel Medical Center, NY (2002)
- MD
- Brooklyn College (1999)
- BS
- Trinity College (1991)
Research
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Overview
Medical Research Interests
Carcinoma, Non-Small-Cell Lung; Clinical Trial, Phase I; Clinical Trial, Phase II; Clinical Trial, Phase III; Immunotherapy; Lung; Medical Oncology; Thoracic Neoplasms; Translational Research, Biomedical
ORCID
0000-0003-0886-6880
Research at a Glance
Yale Co-Authors
Frequent collaborators of Scott Gettinger's published research.
Publications Timeline
A big-picture view of Scott Gettinger's research output by year.
Research Interests
Research topics Scott Gettinger is interested in exploring.
Roy S. Herbst, MD, PhD
David Rimm, MD, PhD
Anna Wurtz
Harriet Kluger, MD
Mario Sznol, MD
Veronica Chiang, MD, FAANS
142Publications
55,247Citations
Carcinoma, Non-Small-Cell Lung
Immunotherapy
Lung
Medical Oncology
Thoracic Neoplasms
Translational Research, Biomedical
Publications
2026
Fast Real-Time Assessment of Combination Therapies in Immuno-ONcology in patients with advanced non-small-cell lung cancer (FRACTION-Lung)
He K, Forde P, Govindan R, Santoro A, Gettinger S, Borghaei H, Spira A, Chu Q, Zinner R, Schoenfeld A, Camidge D, Spigel D, Gurpide A, Juergens R, Laurie S, Cerra M, Spires T, Greenawalt D, Rapoport I, Gainor J. Fast Real-Time Assessment of Combination Therapies in Immuno-ONcology in patients with advanced non-small-cell lung cancer (FRACTION-Lung). ESMO Open 2026, 11: 106078. PMID: 41702354, PMCID: PMC12925557, DOI: 10.1016/j.esmoop.2026.106078.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAdvanced non-small-cell lung cancerDuration of responseNon-small-cell lung cancerProgression-free survivalCombination therapyLung cancerAnti-PD-(L)1 therapyMedian duration of responseNovel immunotherapy combinationsAnti-PD-(L)1Programmed cell death proteinAssessment of combination therapyEvolving treatment landscapeTwenty-four weeksCell death proteinImmunotherapy combinationsPD-(L)1PFS ratesTumor responsePrimary endpointTreatment landscapeMultiple regimensSecondary endpointsEfficacy signalsImmuno-oncology
2025
Activity of Brigatinib in Patients With Crizotinib-Resistant ALK-positive Non–Small-Cell Lung Cancer According to ALK Fusion and Mutation Status
Bazhenova L, Hodgson J, Camidge D, Langer C, Huber R, Kim D, Reckamp K, Ahn M, Tan D, Patel J, Vincent S, Li C, Humphries M, Zhang P, Rivera V, Gettinger S. Activity of Brigatinib in Patients With Crizotinib-Resistant ALK-positive Non–Small-Cell Lung Cancer According to ALK Fusion and Mutation Status. Clinical Lung Cancer 2025, 26: e503-e513.e11. PMID: 40582920, DOI: 10.1016/j.cllc.2025.05.016.Peer-Reviewed Original ResearchCitationsAltmetricConceptsObjective response rateProgression-free survivalMedian progression-free survivalALK-positive NSCLCCirculating tumor DNAALK mutationsALK fusionsMutation statusALK-positive non-small-cell lung cancerNon-small-cell lung cancerPlasma circulating tumor DNAActivity of brigatinibBaseline tumor samplesSecondary ALK mutationsMechanisms of resistanceALK alterationsALK amplificationALK inhibitorsPhase 1/2Preclinical activityTumor DNABrigatinibTumor samplesLung cancerTumor tissues
2024
Phase II Trial of Afatinib in Patients With EGFR-Mutated Solid Tumors Excluding Lung Cancer: Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol A
Gettinger S, Song Z, Reckamp K, Moscow J, Gray R, Wang V, McShane L, Rubinstein L, Patton D, Williams P, Hamilton S, Kong X, Tricoli J, Conley B, Arteaga C, Harris L, O'Dwyer P, Chen A, Flaherty K. Phase II Trial of Afatinib in Patients With EGFR-Mutated Solid Tumors Excluding Lung Cancer: Results From NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol A. JCO Precision Oncology 2024, 8: e2300725. PMID: 38986051, DOI: 10.1200/po.23.00725.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsProgression-free survivalTyrosine kinase inhibitorsEGFR tyrosine kinase inhibitorsNCI-MATCHLung cancerGlioblastoma multiformeOverall survivalAdvanced non-small cell lung cancerNational Cancer Institute-Molecular AnalysisNon-small cell lung cancerEnd pointsTumor genomic testingTrial primary end pointPhase 2 trialPhase II trialSecondary end pointsPrimary end pointCell lung cancerCohort of patientsMedian OSStable diseaseAdenosquamous carcinomaProtocol therapyPartial responseArm ALifileucel, an Autologous Tumor-infiltrating Lymphocyte Monotherapy, in Patients with Advanced Non-small Cell Lung Cancer Resistant to Immune Checkpoint Inhibitors
Schoenfeld A, Lee S, de Speville B, Gettinger S, Hafliger S, Sukari A, Papa S, Rodríguez-Moreno J, Finckenstein F, Fiaz R, Catlett M, Chen G, Qi R, Masteller E, Gontcharova V, He K. Lifileucel, an Autologous Tumor-infiltrating Lymphocyte Monotherapy, in Patients with Advanced Non-small Cell Lung Cancer Resistant to Immune Checkpoint Inhibitors. Cancer Discovery 2024, 14: 1389-1402. PMID: 38563600, PMCID: PMC11294887, DOI: 10.1158/2159-8290.cd-23-1334.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMetastatic non-small cell lung cancerAdverse eventsResistance to immune checkpoint inhibitorsPD-L1-negative tumorsPhase 2 multicenter studyLow tumor mutational burdenTreatment-emergent adverse eventsNon-small cell lung cancerTime of data cutoffRefractory to prior therapyPD-L1-negativeImmune checkpoint inhibitorsResistance to immunotherapyTumor mutational burdenCell lung cancerMultiple organ failurePotential treatment optionCheckpoint inhibitorsPrior therapyData cutoffPatient diedSystemic therapyMutational burdenSTK11 mutationsCardiac failureASCL1 Drives Tolerance to Osimertinib in EGFR Mutant Lung Cancer in Permissive Cellular Contexts
Hu B, Wiesehöfer M, de Miguel F, Liu Z, Chan L, Choi J, Melnick M, Arnal Estape A, Walther Z, Zhao D, Lopez-Giraldez F, Wurtz A, Cai G, Fan R, Gettinger S, Xiao A, Yan Q, Homer R, Nguyen D, Politi K. ASCL1 Drives Tolerance to Osimertinib in EGFR Mutant Lung Cancer in Permissive Cellular Contexts. Cancer Research 2024, 84: 1303-1319. PMID: 38359163, PMCID: PMC11142404, DOI: 10.1158/0008-5472.can-23-0438.Peer-Reviewed Original ResearchCitationsAltmetricConceptsTyrosine kinase inhibitorsPatient-derived xenograftsEGFR mutant lung cancerMutant lung cancerPre-treatment tumorsResidual diseaseDrug toleranceLung cancerResidual tumor cells in vivoEGFR mutant lung adenocarcinomaTyrosine kinase inhibitor osimertinibEGFR tyrosine kinase inhibitorsTyrosine kinase inhibitor treatmentTumor cells in vivoMutant lung adenocarcinomaMaximal tumor regressionTranscription factor Ascl1Drug-tolerant cellsTime of maximal responseEvidence of cellsCells in vivoOsimertinib treatmentTumor regressionSingle cell transcriptional profilingTumor cellsMulti-omics analysis reveals immune features associated with immunotherapy benefit in squamous cell lung cancer patients from Phase III Lung-MAP S1400I trial
Parra E, Zhang J, Duose D, Gonzalez-Kozlova E, Redman M, Chen H, Manyam G, Kumar G, Zhang J, Song X, Lazcano R, Marques-Piubelli M, Laberiano-Fernandez C, Rojas F, Zhang B, Taing L, Jhaveri A, Geisberg J, Altreuter J, Michor F, Provencher J, Yu J, Cerami E, Moravec R, Kannan K, Luthra R, Alatrash G, Huang H, Xie H, Patel M, Nie K, Harris J, Argueta K, Lindsay J, Biswas R, Van Nostrand S, Kim-Schulze S, Gray J, Herbst R, Wistuba I, Gettinger S, Kelly K, Bazhenova L, Gnjatic S, Lee J, Zhang J, Haymaker C. Multi-omics analysis reveals immune features associated with immunotherapy benefit in squamous cell lung cancer patients from Phase III Lung-MAP S1400I trial. Clinical Cancer Research 2024, 30: 1655-1668. PMID: 38277235, PMCID: PMC11016892, DOI: 10.1158/1078-0432.ccr-23-0251.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsChromosome copy-number variationsOverall survivalMultiplex immunofluorescenceMulti-omics analysisAssociated with superior progression-free survivalNCounter PanCancer Immune Profiling PanelSquamous cell lung cancer patientsSuperior progression-free survivalTreated with nivolumab monotherapyAssociated with worse overall survivalNon-small cell carcinomaAssociated with worse survivalCell lung cancer patientsCold immune microenvironmentProgression-free survivalImmune Profiling PanelRegulatory T cellsPhase III trialsResponse to ICIImmune cell infiltrationHigher immune scoresImmune cell densityLung cancer patientsWhole-exome sequencingImmune gene expression profiles
2023
Co-Occurring Alterations in Multiple Tumor Suppressor Genes Are Associated With Worse Outcomes in Patients With EGFR-Mutant Lung Cancer
Stockhammer P, Grant M, Wurtz A, Foggetti G, Expósito F, Gu J, Zhao H, Choi J, Chung S, Li F, Walther Z, Dietz J, Duffield E, Gettinger S, Politi K, Goldberg S. Co-Occurring Alterations in Multiple Tumor Suppressor Genes Are Associated With Worse Outcomes in Patients With EGFR-Mutant Lung Cancer. Journal Of Thoracic Oncology 2023, 19: 240-251. PMID: 37806385, PMCID: PMC11364167, DOI: 10.1016/j.jtho.2023.10.001.Peer-Reviewed Original ResearchCitationsAltmetricConceptsProgression-free survivalEGFR-mutant NSCLCTP53 mutationsOverall survivalClinical outcomesEGFR-TKIInferior outcomesWorse outcomesYale cohortMetastatic EGFR-mutant NSCLCShorter progression-free survivalEGFR-mutant lung cancerTyrosine kinase inhibitor therapyFirst-line TKIYale Cancer CenterSecond-line therapyInferior clinical outcomesSubset of patientsKinase inhibitor therapyAdditional therapeutic interventionsAggressive disease phenotypeCo-occurring alterationsTumor suppressor gene alterationsTumor genomic profilingMultiple tumor suppressor genesMesothelioma: Peritoneal, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology.
Ettinger D, Wood D, Stevenson J, Aisner D, Akerley W, Bauman J, Bharat A, Bruno D, Chang J, Chirieac L, DeCamp M, Dilling T, Dowell J, Durm G, Gettinger S, Grotz T, Gubens M, Hegde A, Lackner R, Lanuti M, Lin J, Loo B, Lovly C, Maldonado F, Massarelli E, Morgensztern D, Mullikin T, Ng T, Otterson G, Patel S, Patil T, Polanco P, Riely G, Riess J, Shapiro T, Singh A, Tam A, Tanvetyanon T, Yanagawa J, Yang S, Yau E, Gregory K, Hughes M. Mesothelioma: Peritoneal, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology. Journal Of The National Comprehensive Cancer Network 2023, 21: 961-979. PMID: 37673108, DOI: 10.6004/jnccn.2023.0045.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsFirst-Line Treatment of Driver-Negative Non–Small Cell Lung Cancer
Kim S, Gettinger S. First-Line Treatment of Driver-Negative Non–Small Cell Lung Cancer. Hematology/Oncology Clinics Of North America 2023, 37: 557-573. PMID: 37150586, DOI: 10.1016/j.hoc.2023.02.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsNon-small cell lung cancerCell lung cancerLung cancerAdvanced non-small cell lung cancerFirst-line settingFirst-line treatmentStandard of careCombination immunotherapyImmunotherapy monotherapyPD-L1Immunotherapy responseLine treatmentSmoking statusTreatment choiceTrial dataCancerImmunotherapyRegimensCliniciansTreatmentChemoimmunotherapyMonotherapyCareNovel Approaches for Dynamic Visualization of Adverse Event Data in Oncology Clinical Trials: A Case Study Using Immunotherapy Trial S1400-I (SWOG)
Lee S, Fan W, Wang A, Vaidya R, Redman M, Gettinger S, Bazhenova L, Herbst R, Hershman D, Unger J. Novel Approaches for Dynamic Visualization of Adverse Event Data in Oncology Clinical Trials: A Case Study Using Immunotherapy Trial S1400-I (SWOG). JCO Clinical Cancer Informatics 2023, 7: e2200165. PMID: 37084329, PMCID: PMC10281446, DOI: 10.1200/cci.22.00165.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSystem organ classAdverse event dataRandomized phase III trialPhase III trialsCell lung cancerOncology clinical trialsOverall toxicity profileIII trialsNeurologic toxicityTreatment armsCardiac toxicityLung cancerClinical trialsGrade 3High prevalenceOrgan classToxicity profileNivolumabTreatment groupsStage IVEndocrine toxicityType of AEToxicity typesAE termsIpilimumab
Clinical Trials
Current Trials
Randomized Phase III Study of Combination Osimertinib (AZD9291) and Bevacizumab Versus Osimertinib (AZD9291) Alone as First-Line Treatment for Patients With Metastatic EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC)
IRB ID2000032879RoleSub InvestigatorPrimary Completion Date12/31/2026Recruiting ParticipantsIntegration of Immunotherapy Into Adjuvant Therapy for Resected NSCLC: ALCHEMIST Chemo-IO (ACCIO)
IRB ID2000028827RoleSub InvestigatorPrimary Completion Date12/15/2024Recruiting ParticipantsLUNGMAP: A Master Protocol To Evaluate Biomarker-Driven Therapies And Immunotherapies In Previously-Treated Non-Small Cell Lung Cancer (Lung-Map Screening Study)
IRB ID2000025282RoleSub InvestigatorPrimary Completion Date01/28/2029Recruiting ParticipantsDetermining Mechanisms of Sensitivity and Resistance to Anti-Cancer Therapy for Advanced Lung Cancer
IRB ID1603017333RolePrincipal InvestigatorPrimary Completion Date06/16/2036Recruiting Participants
Clinical Care
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Overview
Scott Gettinger, MD, is a medical oncologist who specializes in lung cancer treatment and research.
He says the best part of his job is the ability to provide the latest advances in treatment to his patients, many of whom have complicated cases and require care from multiple specialists.
Dr. Gettinger leads several clinical trials evaluating novel therapies for patients with lung cancer. His primary interests include understanding mechanisms of sensitivity and resistance to molecularly targeted therapies and immunotherapies for non-small cell lung cancer.
“Treatment for lung cancer is constantly evolving and new treatments are available to target specific tumors,” he says. “There is always something we can offer that will help.”
Clinical Specialties
Thoracic Oncology; Medical Oncology
Fact Sheets
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News
- November 18, 2025
Progress and Hope: Sharing the Latest Advances in Lung Cancer Care
- November 12, 2025
Twenty-Seven YSM Faculty Members Recognized for Highly Cited Research
- May 30, 2025Source: Yale Medicine
How Smilow Doctors Are Saving My Life: A Cancer Survivor’s Story
- November 14, 2024
Understanding Lung Cancer: A Conference to Raise Awareness and Offer Hope to Those Impacted by Lung Cancer
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