Paula Kavathas, PhD
Professor of Laboratory Medicine, of Immunobiology and of Molecular, Cellular, and Developmental BiologyCards
Appointments
Additional Titles
Vice Chair for Collaborative Excellence, Laboratory Medicine
Vice Chair for Collaborative Excellence, Immunobiology
Institutional Leader, CIRTL Network
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Appointments
Additional Titles
Vice Chair for Collaborative Excellence, Laboratory Medicine
Vice Chair for Collaborative Excellence, Immunobiology
Institutional Leader, CIRTL Network
Contact Info
Appointments
Additional Titles
Vice Chair for Collaborative Excellence, Laboratory Medicine
Vice Chair for Collaborative Excellence, Immunobiology
Institutional Leader, CIRTL Network
Contact Info
About
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Titles
Professor of Laboratory Medicine, of Immunobiology and of Molecular, Cellular, and Developmental Biology
Vice Chair for Collaborative Excellence, Laboratory Medicine; Vice Chair for Collaborative Excellence, Immunobiology
Positions outside Yale
Institutional Leader, CIRTL Network
Biography
Dr. Kavathas studies the T cell co-receptor CD8ab and the functional significance of four isoforms of the human CD8b protein that exist in humans and great apes but not mice. More recently she is studying the basis for acquired resistance to immunotherapy of human lung cancer tumors.
Dr. Kavathas is currently Vice Chair for Collaborative Excellence for both the Departments of Immunobiology and of Laboratory Medicine. She is on the board of SWIM (Status of Women in Medicine), and of the Women’s Faculty Forum (WFF, Chair from 2013-2017). She played a role in diversifying portraits at Yale including commissioning a portrait of the first women PhDs, located in the nave of Sterling Library. Other activities include co-organizing a conference entitled “Gender Rules,” publication of The View (a demographic analysis of women and URMs at Yale), expansion of the Phyllis Bodel Childcare Center, and changes in parental leave policies.
Appointments
Laboratory Medicine
ProfessorPrimaryImmunobiology
ProfessorSecondary
Other Departments & Organizations
Education & Training
- PhD
- University of Wisconsin-Madison (1980)
- BA
- University of Wisconsin-Madison (1972)
Research
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Overview
Medical Research Interests
ORCID
0000-0001-9371-152X
Research at a Glance
Yale Co-Authors
Publications Timeline
John Rose, PhD
Shana Leopold, PhD
Publications
2024
Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease
Zhou X, Shen X, Johnson J, Spakowicz D, Agnello M, Zhou W, Avina M, Honkala A, Chleilat F, Chen S, Cha K, Leopold S, Zhu C, Chen L, Lyu L, Hornburg D, Wu S, Zhang X, Jiang C, Jiang L, Jiang L, Jian R, Brooks A, Wang M, Contrepois K, Gao P, Rose S, Tran T, Nguyen H, Celli A, Hong B, Bautista E, Dorsett Y, Kavathas P, Zhou Y, Sodergren E, Weinstock G, Snyder M. Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease. Cell Host & Microbe 2024, 32: 506-526.e9. PMID: 38479397, PMCID: PMC11022754, DOI: 10.1016/j.chom.2024.02.012.Peer-Reviewed Original ResearchCitationsAltmetric
1993
Identification and Characterization of an Alu-Containing, T-Cell-Specific Enhancer Located in the Last Intron of the Human CD8α Gene
Hambor J, Mennone J, Coon M, Hanke J, Kavathas P. Identification and Characterization of an Alu-Containing, T-Cell-Specific Enhancer Located in the Last Intron of the Human CD8α Gene. Molecular And Cellular Biology 1993, 13: 7056-7070. DOI: 10.1128/mcb.13.11.7056-7070.1993.Peer-Reviewed Original ResearchIdentification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene.
Hambor J, Mennone J, Coon M, Hanke J, Kavathas P. Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene. Molecular And Cellular Biology 1993, 13: 7056-7070. DOI: 10.1128/mcb.13.11.7056.Peer-Reviewed Original ResearchAltmetric
1990
Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase.
Shaw A, Chalupny J, Whitney J, Hammond C, Amrein K, Kavathas P, Sefton B, Rose J. Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase. Molecular And Cellular Biology 1990, 10: 1853-1862. DOI: 10.1128/mcb.10.5.1853.Peer-Reviewed Original ResearchAltmetric
1988
Epstein-Barr virus shuttle vector for stable episomal replication of cDNA expression libraries in human cells.
Margolskee R, Kavathas P, Berg P. Epstein-Barr virus shuttle vector for stable episomal replication of cDNA expression libraries in human cells. Molecular And Cellular Biology 1988, 8: 2837-2847. DOI: 10.1128/mcb.8.7.2837.Peer-Reviewed Original ResearchAltmetric
1986
Transfer of cloned human class I major histocompatibility complex genes into HLA mutant human lymphoblastoid cells.
Shimizu Y, Koller B, Geraghty D, Orr H, Shaw S, Kavathas P, DeMars R. Transfer of cloned human class I major histocompatibility complex genes into HLA mutant human lymphoblastoid cells. Molecular And Cellular Biology 1986, 6: 1074-1087. DOI: 10.1128/mcb.6.4.1074.Peer-Reviewed Original ResearchAltmetric
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Locations
kavathas
Lab
The Anlyan Center
300 Cedar Street, Ste S540
New Haven, CT 06519
Appointments
203.785.6223