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Markus Müschen, MD, PhD

Arthur H. and Isabel Bunker Professor of Medicine (Hematology) and Professor of Immunobiology; Director, Center of Molecular and Cellular Oncology; Chief, Division of Basic Science

Appointments

Biography

Markus Müschen, MD-PhD, is the Director of the Center of Molecular and Cellular Oncology, Arthur H. and Isabel Bunker Professor of Hematology, and Professor of Immunobiology at Yale University. He also serves as Chief of the Division of Basic Science of Yale Cancer Center. His research program focuses on signal transduction mechanisms in lymphoid malignancies and how these pathways can be intercepted for the treatment of drug-resistant leukemia and lymphoma. His laboratory established new conceptual frameworks for the understanding of B-cell signaling and energy metabolism and how these mechanisms are altered in lymphoid malignancies.

Markus Müschen studied medicine at the Heinrich-Heine-Universität Düsseldorf, Germany, Université de Nantes, France and the Institut Pasteur, Paris, France. After his clinical training in hematology-oncology with Volker Diehl at the University of Cologne, he completed postdoctoral fellowships in immunology with Klaus Rajewsky and Ralf Küppers and in leukemia genetics with Janet D. Rowley at the University of Chicago.

Before coming to Yale, Markus Müschen’s laboratory was at the University of California San Francisco (UCSF, 2010-2017) where he served as Program Leader of the Hematological Malignancies Program at the UCSF Comprehensive Cancer Center. Markus Müschen is currently a Howard Hughes Medical Institute (HHMI) Faculty Scholar, an elected member of the American Society of Clinical Investigation, the Connecticut Academy of Science and the Scientific Advisory Board of the Lymphoma Research Foundation. His research has been supported by an NCI Outstanding Investigator Award (R35) since 2016. As Director of the Center of Molecular and Cellular Oncology at Yale, he serves as mentor for nine junior faculty.

Müschen Laboratory Drug Discovery platform: http://lymphoblasts.org/

Education & Training

  • Visiting Assistant Professor
    Children's Hospital Los Angeles and University of Southern California (2009)
  • Residency and Fellowship
    University of Cologne (2006)
  • PhD
    Institute for Genetics Cologne, Immunology (2003)
  • MD-PhD thesis
    University of Cologne (2003)
  • Postdoctoral fellowship
    University of Chicago (2002)
  • Postdoctoral fellowship
    Institute for Genetics, University of Cologne (2000)
  • MD
    Heinrich-Heine-Universität Düsseldorf, Biochemistry (1999)
  • MD thesis
    Heinrich-Heine-Universitaet Duesseldorf (1999)

Honors & Recognition

AwardAwarding OrganizationDate
Elected MemberConnecticut Academy of Science2023
NCI Outstanding Investigator Award 2021National Cancer Institute2021
Elected Member, ASCIAmerican Society of Clinical Investigation2019
18th Annual Maxwell M. Wintrobe Endowed LectureUniversity of Utah2018
Stephen D. Williams, MD, LectureshipIndiana University2018
20th Andrew I. Schafer Distinguished LectureCornell University2018
Norman and Sadie Lee Foundation Endowed ChairNorman and Sadie Lee Foundation2017
NCI Outstanding Investigator Award (R35)National Cancer Institute2016
Howard Hughes Medical Institute Faculty Scholar AwardHoward Hughes Medical Institute2016
Cancer Research UK Programme AwardCancer Research UK2014
Honorary faculty appointmentCambridge University2014
Wellcome Trust Senior Investigator AwardWellcome Trust2013
Sir Alexander Haddow ProfessorshipThe Institute for Cancer Research (ICR)2012
Scholar AwardLeukemia and Lymphoma Society2011
Stand Up To Cancer InnovationAmerican Association for Cancer Research2009
Leukemia Clinical Research AwardGerman Society of Hematology and Oncology2006
Fritz-Melchers-Award in ImmunologyGerman Association of Immunologists2003
Emmy-Noether-AwardGerman Science Foundation (DFG)2002
Irvington Postdoctoral Fellowship AwardCancer Research Institute2000

Professional Service

OrganizationRoleDate
Scientific Advisory Board, Lymphoma Research FoundationMember2023 - Present
Scientific Advisory Board, The Blood Research Institute, Milwaukee, WIMember2021 - Present
Hôpital Necker-Enfants Malades Scientific Advisory Board, Hôpital Necker-Enfants MaladesScientific Advisor2018 - Present
NIH Molecular Oncogenesis (MONC) study sectionMember2016 - Present
Biological ChemistryAssociate Editor2009 - Present
Leukemia, Nature Publishing GroupAssociate Editor2008 - 2014

Departments & Organizations