Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection
Yang CX, Tomchaney M, Landecho MF, Zamacona BR, Oto M, Zulueta J, Malo J, Knoper S, Contoli M, Papi A, Vasilescu DM, Sauler M, Straub C, Tan C, Martinez FD, Bhattacharya D, Rosas IO, Kheradmand F, Hackett TL, Polverino F. Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection. Cells 2022, 11: 1864. PMID: 35740993, PMCID: PMC9220844, DOI: 10.3390/cells11121864.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCOPD patientsLung parenchymaFatal SARS-CoV-2 infectionsMemory CD4 T cell responsesPre-existing lung diseaseCD4 T cell responsesSARS-CoV-2 infectionSARS-CoV-2 entryMemory T cell differentiationSARS-CoV-2 disease 2019Obstructive pulmonary diseaseT cell responsesT-cell signatureCOVID-19 infectionCOVID-19T cell differentiationAntigen primingMemory CD4Pulmonary diseaseControl lungsImmune microenvironmentLung diseaseT cellsT lymphocytesCompromised Cardiopulmonary Function in Fibulin-5 Deficient Mice.
Ramachandra AB, Mikush N, Sauler M, Humphrey JD, Manning EP. Compromised Cardiopulmonary Function in Fibulin-5 Deficient Mice. Journal Of Biomechanical Engineering 2022, 144 PMID: 35171214, PMCID: PMC8990734, DOI: 10.1115/1.4053873.Peer-Reviewed Original ResearchConceptsRight heart functionDeficient micePulmonary arteryHeart functionCompromised right ventricular functionFibulin-5 deficient micePulmonary arterial structureRight ventricular functionVentilation-perfusion relationshipsElastic fiber contentElastic fibersFiber dysfunctionLung compliancePulmonary healthVentricular functionCardiopulmonary functionAlveolar disruptionPulmonary pathologyLung parenchymaMurine modelMouse modelArterial structureHistological quantificationElastic laminaRight circulation