Luke Brown, PhD
Postdoctoral AssociateAbout
Research
Publications
Featured Publications
Visualizing a lung neutrophil-platelet immunothrombosis cascade during sepsis in mice
Brown L, Schlechte J, Rashid M, Lou Y, Nguyen A, Hassanabad M, Hiroki C, Cobo E, Hollenberg M, McDonald B, Yipp B. Visualizing a lung neutrophil-platelet immunothrombosis cascade during sepsis in mice. Science 2026, 392: eadv0377. PMID: 42207885, DOI: 10.1126/science.adv0377.Peer-Reviewed Original Research
2025
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis
Hiroki C, Hassanabad M, Defaye M, Sarden N, Bartlett A, Farias R, Nguyen A, Guerrero-Fonseca I, Yoon G, Brown L, Ma C, Yang H, Belke D, Fatehi Hassanabad A, McCoy C, Rosin N, Orton D, Fedak P, Vallance B, Yu H, Jacobson K, Khan N, Altier C, Kelly M, Yipp B. Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis. Immunity 2025, 58: 2054-2068.e6. PMID: 40449484, DOI: 10.1016/j.immuni.2025.05.002.Peer-Reviewed Original Research
2024
Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection
Granton E, Brown L, Defaye M, Moazen P, Almblad H, Randall T, Rich J, Geppert A, Abdullah N, Hassanabad M, Hiroki C, Farias R, Nguyen A, Schubert C, Lou Y, Andonegui G, Iftinca M, Raju D, Vargas M, Howell P, Füzesi T, Bains J, Kurrasch D, Harrison J, Altier C, Yipp B. Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection. Cell 2024, 187: 1874-1888.e14. PMID: 38518773, DOI: 10.1016/j.cell.2024.03.001.Peer-Reviewed Original Research
2023
Neutrophil swarming: Is a good offense the best defense?
Brown L, Yipp B. Neutrophil swarming: Is a good offense the best defense? IScience 2023, 26: 107655. PMID: 37670784, PMCID: PMC10475518, DOI: 10.1016/j.isci.2023.107655.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
Inflammatory platelet death drives sepsis
Brown L, Yipp B. Inflammatory platelet death drives sepsis. Nature Cardiovascular Research 2022, 1: 689-690. PMID: 35975232, PMCID: PMC9372963, DOI: 10.1038/s44161-022-00111-y.Peer-Reviewed Original ResearchSurfactant Protein D Influences Mortality During Abdominal Sepsis by Facilitating Escherichia coli Colonization in the Gut
Varon J, Arciniegas Rubio A, Amador-Munoz D, Corcoran A, DeCorte J, Isabelle C, Pinilla Vera M, Walker K, Brown L, Cernadas M, Bry L, Yang H, Kitsios G, McVerry B, Morris A, Lee H, Howrylak J, Englert J, Baron R. Surfactant Protein D Influences Mortality During Abdominal Sepsis by Facilitating Escherichia coli Colonization in the Gut. Critical Care Explorations 2022, 4: e0699. PMID: 35620769, PMCID: PMC9119639, DOI: 10.1097/cce.0000000000000699.Peer-Reviewed Original Research
2021
Peritoneal macrophages are impaired in cathelicidin-deficient mice systemically challenged with Escherichia coli
Boucher E, Brown L, Lahiri P, Cobo E. Peritoneal macrophages are impaired in cathelicidin-deficient mice systemically challenged with Escherichia coli. Cell And Tissue Research 2021, 383: 1203-1208. PMID: 33496883, DOI: 10.1007/s00441-020-03362-y.Peer-Reviewed Original Research
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