1996
SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics
Greenwood J, Pryce G, Devine L, Male D, dos Santos W, Calder V, Adamson P. SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics. Journal Of Neuroimmunology 1996, 71: 51-63. PMID: 8982103, DOI: 10.1016/s0165-5728(96)00130-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Polyomavirus TransformingAntigens, SurfaceBiological TransportBlood-Brain BarrierCell Adhesion MoleculesCell MovementCell Transformation, ViralEndotheliumEndothelium, VascularFluorescent Antibody Technique, IndirectHistocompatibility AntigensLipoproteins, LDLPigment Epithelium of EyeRatsRetinaSimian virus 40T-LymphocytesConceptsRetinal pigment epitheliumBlood-retinal barrierRetinal endotheliumAdhesion moleculesCell adhesion moleculeCell linesAntigen-specific T cell linesImmortalised cell linesMajor histocompatibility complex class 1Vascular cell adhesion moleculeRat brain endotheliumMHC class IIEndothelial cell adhesion moleculesIntercellular adhesion moleculeCentral nervous systemLectin Griffonia simplicifoliaPlatelet endothelial cell adhesion moleculeHigh-affinity uptakeT cell linesPigmented epithelial cellsRPE cell lineVon Willebrand factorEndothelial cell lineNeural parenchymaBrain endotheliumRole of LFA‐1, ICAM‐1, VLA‐4 and VCAM‐1 in lymphocyte migration across retinal pigment epithelial monolayers in vitro
DEVINE L, LIGHTMAN S, GREENWOOD J. Role of LFA‐1, ICAM‐1, VLA‐4 and VCAM‐1 in lymphocyte migration across retinal pigment epithelial monolayers in vitro. Immunology 1996, 88: 456-462. PMID: 8774365, PMCID: PMC1456340, DOI: 10.1046/j.1365-2567.1996.d01-666.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood-Retinal BarrierCD4-Positive T-LymphocytesCell Adhesion MoleculesCell Culture TechniquesCell MovementChemotaxis, LeukocyteEnzyme-Linked Immunosorbent AssayFlow CytometryIntercellular Adhesion Molecule-1Microscopy, ElectronPigment Epithelium of EyeRatsRats, Inbred StrainsVascular Cell Adhesion Molecule-1ConceptsBlood-retinal barrierRetinal pigment epitheliumLFA-1 betaICAM-1VCAM-1VLA-4Vascular endotheliumLymphocyte migrationAntigen-specific T cell linesAdhesion moleculesRetinal vascular endotheliumMigration of CD4Traffic of lymphocytesOcular inflammatory conditionsLFA-1 alphaVCAM-1 expressionRetinal pigment epithelial monolayerRPE cell monolayersT cell linesPosterior uveitisLymphocyte trafficInflammatory conditionsPosterior barrierCell adhesion moleculeIFN-gammaLymphocyte Migration across the Anterior and Posterior Blood–Retinal Barrierin Vitro
Devine L, Lightman S, Greenwood J. Lymphocyte Migration across the Anterior and Posterior Blood–Retinal Barrierin Vitro. Cellular Immunology 1996, 168: 267-275. PMID: 8640874, DOI: 10.1006/cimm.1996.0075.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensArrestinBlood-Retinal BarrierCell AdhesionCell LineChemotaxis, LeukocyteEndothelium, VascularEye ProteinsInterferon-gammaInterleukin-1Lymph NodesLymphocyte ActivationLymphocyte SubsetsMuromonab-CD3OvalbuminPigment Epithelium of EyeRatsRats, Inbred LewRats, Inbred StrainsReceptor-CD3 Complex, Antigen, T-CellRecombinant ProteinsRetinal VesselsSpecific Pathogen-Free OrganismsT-Lymphocytes, Helper-InducerTuberculinConceptsAntigen-specific T cell linesRat retinal pigment epitheliumBlood-retinal barrierT cell linesPLN cellsEndothelial cellsLymphocyte migrationPeripheral lymph node cellsCell linesRetinal vascular endotheliumLymph node cellsCross-linking CD3Migration of lymphocytesRetinal endothelial cellsRetinal pigment epitheliumCombination of CD3PVG ratsRetinal endotheliumIFN-gamma activationLewis ratsNode cellsS-antigenICAM-1IFN-gammaPigment epitheliumA Comparison of Lymphocyte Migration Across the Anterior and Posterior Blood-Retinal Barrier in Vitro
Devine L, Lightman S, Greenwood J. A Comparison of Lymphocyte Migration Across the Anterior and Posterior Blood-Retinal Barrier in Vitro. Advances In Behavioral Biology 1996, 46: 245-251. DOI: 10.1007/978-1-4757-9489-2_41.Peer-Reviewed Original ResearchBlood-retinal barrierCentral nervous systemRetinal pigment epitheliumImmune mediated diseasesSystemic immune systemVLA-4/VCAMTraffic of lymphocytesLFA-1/ICAMBlood-tissue barriersMediated diseasesCytokine activationLymphocyte migrationVascular endotheliumPigment epitheliumNervous systemImmune systemRPE monolayerAdhesion moleculesLymphocytesVascular endothelialReceptor-ligand pairingsCellular barriersEyesSeparate sitesVCAM
1995
The Blood-Retinal Barrier in Immune-Mediated Diseases of the Retina
Greenwood J, Bamforth S, Wang Y, Devine L. The Blood-Retinal Barrier in Immune-Mediated Diseases of the Retina. 1995, 315-326. DOI: 10.1007/978-1-4899-1054-7_31.Peer-Reviewed Original ResearchBlood-brain barrierBlood-retinal barrierBlood-CSF barrierCentral nervous systemTight junctionsBlood-tissue barriersFenestrated vasculatureCerebral parenchymaCerebral vasculatureChoroid plexusNervous systemEndothelial cellsChoroidal epitheliumExtracellular fluidDelicate homeostasisRetinaSystemic influencesBrainVasculatureCellular barriersPlexusNeuroretinaDiseaseBloodParenchyma