1998
Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals
Kim S, Reed D, Olson S, Schnell M, Rose J, Morton P, Lefrançois L. Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 10814-10819. PMID: 9724787, PMCID: PMC27978, DOI: 10.1073/pnas.95.18.10814.Peer-Reviewed Original ResearchConceptsCD8 T cellsT cellsT lymphocytesPrimary CD8 T cell responseCD8 T cell responsesMucosal cytotoxic T lymphocytesPeripheral CD8 T cellsMajor histocompatibility complex class IActivation of peripheralMucosal T cellsT cell responsesHistocompatibility complex class ICytotoxic T cellsCytotoxic T lymphocytesT cell generationComplex class IInflammatory mediatorsPeripheral toleranceAntigen administrationCostimulatory requirementsMucosal sitesAdjuvant effectB7-1B7-2Inflammatory signals
1990
Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase.
Shaw A, Chalupny J, Whitney J, Hammond C, Amrein K, Kavathas P, Sefton B, Rose J. Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase. Molecular And Cellular Biology 1990, 10: 1853-1862. PMID: 2109184, PMCID: PMC360530, DOI: 10.1128/mcb.10.5.1853.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntigens, Differentiation, T-LymphocyteBase SequenceCD4 AntigensCD8 AntigensCysteineCytoplasmDNA Mutational AnalysisHumansIn Vitro TechniquesLymphocyte Specific Protein Tyrosine Kinase p56(lck)Molecular Sequence DataProtein BindingProtein-Tyrosine KinasesSignal TransductionStructure-Activity RelationshipConceptsAmino-terminal domainTyrosine protein kinaseCytoplasmic domainProtein kinaseBinding of p56lckCommon sequence motifsRelated amino acid sequencesAmino acid sequenceDisulfide bond formationCD8 alphaAmino acid residuesSequence motifsHybrid proteinCysteine residuesAcid sequenceUnrelated proteinsAlpha proteinRelated sequencesAcid residuesCD4 sequencesP56lckGlycoprotein CD4HeLa cellsProteinKinase