Helene Benveniste, MD, PhD
Anthony N. Brady Professor of AnesthesiologyCards
Appointments
Contact Info
Anesthesiology
PO Box 208051
New Haven, CT 06520-8051
United States
About
Titles
Anthony N. Brady Professor of Anesthesiology
Biography
Dr. Benveniste is a Professor of Anesthesiology at Yale. She received her Bachelors degree in Mathematics & Physics from Katedralskolen, Denmark, and went on to study at the University of Copenhagen, where she received her MD in 1989 and PhD (Doctor Medicinae) in 1991. As a Research Fellow, she trained in high field magnetic resonance imaging (MRI) at Duke University Medical Center with Dr. G. Allen Johnson and developed techniques for brain imaging focused on neurodegenerative disease processes, including Alzheimer’s Disease. She went on to pursue her internship training in Family Medicine and her residency in Anesthesiology also at Duke University. Dr. Benveniste joined the faculty of Duke University's department of Anesthesiology in 1996, where she continued her work in developing diagnostic MRI based platforms for early detection of AD.
In 2001 Dr. Benveniste joined the department of Anesthesiology at Stony Book Medical Center as faculty and set up a preclinical MRI facility at Brookhaven National Laboratory; PET technology was integrated into her work to measure the bioavailability and pharmacokinetics of psychoactive compounds and anesthetic drugs. In 2015, Dr. Benveniste’s laboratory became involved with studies of the ‘glymphatic pathway’ which is a novel peri-vascular based system in the central nervous system involved in brain waste removal. Dr. Benveniste has received national and international recognition for her work. In November of 2016, Benveniste moved to Yale University, where she joined the Department of Anesthesiology and is expanding her research program in understanding how the glymphatic system and cerebrospinal fluid transport is affected in neurodegenerative disease states and aging.
Appointments
Anesthesiology
ProfessorPrimary
Other Departments & Organizations
- Anesthesiology
- Center for Brain & Mind Health
- MR Core
- Vascular Biology and Therapeutics Program
- Yale Biomedical Imaging Institute
Education & Training
- PhD
- University of Copenhagen, Neurobiology (1991)
- MD
- University of Copenhagen (1986)
Research
Overview
Medical Research Interests
ORCID
0000-0002-2887-6667
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Sunil Koundal
Douglas Rothman, PhD
D. S. Fahmeed Hyder, PhD
Hedok Lee
Jean-Leon Thomas, PhD
Kevin Behar, PhD
Brain
Central Nervous System
Cerebrospinal Fluid
Anesthesia
Publications
2025
Reduced removal of waste products from energy metabolism takes center stage in human brain aging
Mangia S, DiNuzzo M, Ponticorvo S, Dienel G, Behar K, Benveniste H, Hyder F, Giove F, Herculano-Houzel S, Petroff O, Eberly L, Filip P, Michaeli S, Rothman D. Reduced removal of waste products from energy metabolism takes center stage in human brain aging. Scientific Reports 2025, 15: 8127. PMID: 40057554, PMCID: PMC11890754, DOI: 10.1038/s41598-025-90342-3.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsDoes semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial)
Klausen M, Kuzey T, Pedersen J, Justesen S, Rasmussen L, Knorr U, Mason G, Ekstrøm C, Holst J, Koob G, Benveniste H, Volkow N, Knudsen G, Vilsbøll T, Fink-Jensen A. Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial). BMJ Open 2025, 15: e086454. PMID: 39779270, PMCID: PMC11749217, DOI: 10.1136/bmjopen-2024-086454.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAlcohol use disorderUse disorderGamma-aminobutyric acidComorbid obesityAlcohol cue reactivityCognitive behavioral therapyHeavy drinking daysWhite matter tract integrityBrain gamma-aminobutyric acidGlucagon-like peptide-1Alcohol consumptionMental health disordersReduce alcohol consumptionClinical trialsCue reactivityPlacebo-controlled clinical trialBehavioral therapyDrinking daysFunctional connectivityGLP-1 receptor agonist semaglutideWeeks of treatmentDouble-blind clinical trialTract integrityEthics Committee of the Capital Region of DenmarkHealth disorders3 Cerebrospinal Fluid
Al Bizri E, Benveniste H. 3 Cerebrospinal Fluid. 2025, 67-76. DOI: 10.1016/b978-0-323-93273-8.00003-1.Peer-Reviewed Original Research
2024
Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease
Koundal S, Chen X, Gursky Z, Lee H, Xu K, Liang F, Xie Z, Xu F, Lin H, Van Nostrand W, Gu X, Elkin R, Tannenbaum A, Benveniste H. Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease. IScience 2024, 27: 111463. PMID: 39720539, PMCID: PMC11667077, DOI: 10.1016/j.isci.2024.111463.Peer-Reviewed Original ResearchElucidating a new path of CSF transport in the CNS
Benveniste H, Thomas J. Elucidating a new path of CSF transport in the CNS. The Lancet Neurology 2024, 23: 553-554. PMID: 38760087, PMCID: PMC11700482, DOI: 10.1016/s1474-4422(24)00164-9.Peer-Reviewed Original ResearchIs CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies
van Veluw S, Benveniste H, Bakker E, Carare R, Greenberg S, Iliff J, Lorthois S, Van Nostrand W, Petzold G, Shih A, van Osch M. Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies. Cellular And Molecular Life Sciences 2024, 81: 239. PMID: 38801464, PMCID: PMC11130115, DOI: 10.1007/s00018-024-05277-1.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsBrain maps of pCO2, pO2 and pH in aging via homeostatic modeling of neuroimaging data across the lifespan
Mangia S, DiNuzzo M, Dienel G, Behar K, Benveniste H, Giove F, Herculano S, Wolf M, Li X, Filip P, Michaeli S, Rothman D. Brain maps of pCO2, pO2 and pH in aging via homeostatic modeling of neuroimaging data across the lifespan. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/3889.Peer-Reviewed Original ResearchVEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model
Boisserand L, Geraldo L, Bouchart J, Kamouh M, Lee S, Sanganahalli B, Spajer M, Zhang S, Lee S, Parent M, Xue Y, Skarica M, Yin X, Guegan J, Boyé K, Leser F, Jacob L, Poulet M, Li M, Liu X, Velazquez S, Singhabahu R, Robinson M, Askenase M, Osherov A, Sestan N, Zhou J, Alitalo K, Song E, Eichmann A, Sansing L, Benveniste H, Hyder F, Thomas J. VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model. Journal Of Experimental Medicine 2024, 221: e20221983. PMID: 38442272, PMCID: PMC10913814, DOI: 10.1084/jem.20221983.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsVascular endothelial growth factor-CDeep cervical lymph nodesCentral nervous systemEffect of vascular endothelial growth factor-CMeningeal lymphatic vesselsAmeliorated motor performanceCervical lymph nodesIschemic strokeVEGF-C overexpressionIncreased BDNF signalingAcute ischemic strokeBrain cellsIncreased CSF drainageIschemic stroke outcomesModel of ischemic strokeMouse model of ischemic strokeImmune surveillanceCSF drainageLymph nodesFluid drainageNucleus RNA sequencingLymphatic growthLymphatic drainageMouse modelBDNF signalingA translational approach towards understanding brain waste clearance in cerebral amyloid angiopathy
van Veluw S, Benveniste H, van Osch M, Bakker E, Carare R, Greenberg S, Iliff J, Lorthois S, Van Nostrand W, Petzold G, Shih A. A translational approach towards understanding brain waste clearance in cerebral amyloid angiopathy. European Heart Journal 2024, 45: 1500-1502. PMID: 38289319, DOI: 10.1093/eurheartj/ehae011.Peer-Reviewed Original ResearchUnbalanced regularized optimal mass transport with applications to fluid flows in the brain
Chen X, Benveniste H, Tannenbaum A. Unbalanced regularized optimal mass transport with applications to fluid flows in the brain. Scientific Reports 2024, 14: 1111. PMID: 38212659, PMCID: PMC10784574, DOI: 10.1038/s41598-023-50874-y.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsFluid flowMass transportEntire transport processNumerical solution procedureKinetic energyTotal kinetic energyImage trackingSolution procedureOptimal mass transportTransport processesMass transport approachTransport problemsMass configurationConstraint equationsFlowTransport approachApplicationsBenamouFormulationTransportTracking
News
News
- March 06, 2022Source: YaleNews
Waste Management in the Brain May Shed Light on Dementia
- July 05, 2020
Sleep: memory's careful custodian
- February 04, 2020
The Departments of Anesthesiology and Neurology Host: “Perivascular Spaces in the Brain & Contributions to Pathology of Cerebral Small Vessel Disease” on March 24
- September 17, 2018
Nora D. Volkow, MD, Director of the National Institute on Drug Abuse, to Keynote Third Annual Anesthesiology Department Research Retreat, Oct. 5-6
Get In Touch
Contacts
Anesthesiology
PO Box 208051
New Haven, CT 06520-8051
United States
Locations
Tompkins Memorial Pavilion
Academic Office
789 Howard Avenue, Fl 3rd, Rm 332
New Haven, CT 06519