2024
Transmembrane pH gradient imaging in rodent glioma models
Mishra S, Santana J, Mihailovic J, Hyder F, Coman D. Transmembrane pH gradient imaging in rodent glioma models. NMR In Biomedicine 2024, 37: e5102. PMID: 38263680, PMCID: PMC10987279, DOI: 10.1002/nbm.5102.Peer-Reviewed Original ResearchNormal tissuesRodent glioma modelsGL261 gliomasU87 gliomasTumor microenvironmentPotential therapeutic targetGlioma modelTumor survivalExtracellular acidosisTumorMetabolic reprogrammingRegulate drug deliveryIntracellular pHRat brainExtracellular pHTherapeutic targetGliomaMouse brainDrug deliveryIntracellular milieuTransmembrane pH gradientBrainSubmillimeter resolutionTissueCells
2022
Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery
Zhang S, Peng B, Chen Z, Yu J, Deng G, Bao Y, Ma C, Du F, Sheu WC, Kimberly WT, Simard JM, Coman D, Chen Q, Hyder F, Zhou J, Sheth KN. Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery. Bioactive Materials 2022, 16: 57-65. PMID: 35386312, PMCID: PMC8958421, DOI: 10.1016/j.bioactmat.2022.02.033.Peer-Reviewed Original ResearchDrug deliveryStroke treatmentTherapeutic agentsBetulinic acidNatural nanomaterialsSurface conjugationDrug releaseDrug carriersAntioxidant nanoparticlesEfficient carrierTreatment of strokeEffective pharmacological treatmentCause of deathNanoparticlesPotent therapeutic agentIschemic brainPharmacological treatmentCXCR4 antagonistIntravenous administrationSignificant efficacyIschemic tissueNeuroprotective peptidePotent antioxidantStrokeCarriers