2020
Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19
Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Dela Cruz C, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Barakat LA. Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. BMC Neurology 2020, 20: 248. PMID: 32552792, PMCID: PMC7301053, DOI: 10.1186/s12883-020-01812-2.Peer-Reviewed Original ResearchConceptsInitial presentationCentral nervous system inflammationSARS-CoV-2 infectionCSF inflammatory markersNervous system inflammationCerebrospinal fluid (CSF) cytokinesSeizure-like activityCOVID-19 infectionVirus SARS-CoV-2COVID-19SARS-CoV-2BackgroundCOVID-19Inflammatory markersNeurologic complicationsSystem inflammationImmunocompromised womanNeurologic manifestationsNeurologic symptomsViral neuroinvasionCase presentationWeInfected patientsMental statusRespiratory pathogensConclusionOur findingsInflammation
2015
Impact on Patient Management and Outcome of Switching between 2 Contemporary Sensitive Cardiac Troponin Assays
Wilen CB, Szymanski JJ, Hung S, Rajan A, Lavigne PM, Char DM, Geltman EM, Scott MG. Impact on Patient Management and Outcome of Switching between 2 Contemporary Sensitive Cardiac Troponin Assays. Clinical Chemistry 2015, 61: 870-876. PMID: 25886769, DOI: 10.1373/clinchem.2015.238089.Peer-Reviewed Original ResearchCriteria for Reducing Unnecessary Testing for Herpes Simplex Virus, Varicella-Zoster Virus, Cytomegalovirus, and Enterovirus in Cerebrospinal Fluid Samples from Adults
Wilen CB, Monaco CL, Hoppe-Bauer J, Jackups R, Bucelli RC, Burnham CA. Criteria for Reducing Unnecessary Testing for Herpes Simplex Virus, Varicella-Zoster Virus, Cytomegalovirus, and Enterovirus in Cerebrospinal Fluid Samples from Adults. Journal Of Clinical Microbiology 2015, 53: 887-895. PMID: 25568435, PMCID: PMC4390640, DOI: 10.1128/jcm.03161-14.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCerebrospinal FluidCohort StudiesCosts and Cost AnalysisCytomegalovirusEnterovirusHerpesvirus 3, HumanHumansLeukocyte CountLeukocytes, MononuclearMeningitis, AsepticMiddle AgedMolecular Diagnostic TechniquesNucleic Acid Amplification TechniquesRetrospective StudiesSensitivity and SpecificitySimplexvirusConceptsNucleic acid amplification testingVaricella-zoster virusCerebrospinal fluid samplesHSV-1/2Unnecessary testingHerpes simplex virus 1/2Retrospective observational studyCells/Fluid samplesComputerized order setsHerpes simplex virusHealth care costsNAAT assaysImmunocompetent adultsImmunocompetent subjectsValidation cohortAmplification testingObservational studyPositive testCSF samplesEV testingSimplex virusLimited followClinical specificityCare costs