Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism
Jiang C, Parrish N, Wilen C, Li H, Chen Y, Pavlicek J, Berg A, Lu X, Song H, Tilton J, Pfaff J, Henning E, Decker J, Moody M, Drinker M, Schutte R, Freel S, Tomaras G, Nedellec R, Mosier D, Haynes B, Shaw G, Hahn B, Doms R, Gao F. Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism. Journal Of Virology 2011, 85: 10669-10681. PMID: 21835785, PMCID: PMC3187499, DOI: 10.1128/jvi.05249-11.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SubstitutionApelin ReceptorsCD4-Positive T-LymphocytesCells, CulturedEnv Gene Products, Human Immunodeficiency VirusGene ExpressionHIV-1HumansMacrophagesReceptors, Formyl PeptideReceptors, G-Protein-CoupledReceptors, HIVReceptors, LipoxinReceptors, PeptideViral TropismConceptsF virusesHuman immunodeficiency virus type 1Immunodeficiency virus type 1Alternative coreceptor GPR15Sequential plasma samplesHuman immunodeficiency virusClade B virusesVirus type 1Cell linesPrimary human CD4Third variable loopEarly time pointsCoreceptor tropismFounder virusesMultiple CD4Immunodeficiency virusAlternative coreceptorsCCR5 coreceptorPrimary infectionB virusCXCR4 coreceptorFPRL-1T cellsHuman CD4Homozygous donorsPhenotypic and Immunologic Comparison of Clade B Transmitted/Founder and Chronic HIV-1 Envelope Glycoproteins
Wilen CB, Parrish NF, Pfaff JM, Decker JM, Henning EA, Haim H, Petersen JE, Wojcechowskyj JA, Sodroski J, Haynes BF, Montefiori DC, Tilton JC, Shaw GM, Hahn BH, Doms RW. Phenotypic and Immunologic Comparison of Clade B Transmitted/Founder and Chronic HIV-1 Envelope Glycoproteins. Journal Of Virology 2011, 85: 8514-8527. PMID: 21715507, PMCID: PMC3165820, DOI: 10.1128/jvi.00736-11.Peer-Reviewed Original ResearchConceptsMucosal barrierF EnvsNeutralization sensitivitySingle-round infectivity assaysHuman immunodeficiency virus type 1Immunodeficiency virus type 1Enhanced neutralization sensitivityTransmitted/FounderHIV-1 envelope glycoproteinHIV-1 transmissionIntact mucosal barrierClade B EnvVirus type 1Chronic EnvsHIV-IgDendritic cellsCoreceptor tropismFounder virusesSexual transmissionEnv phenotypeAntibody b12Chronic controlEffective vaccineNew infectionsEnv trimers