Costin Ionescu, MD, PhD
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Cardiovascular Medicine
Primary
Titles
Clinician
Contact Info
Cardiovascular Medicine
175 Sherman Ave, 6th floor
New Haven, CT 06511
United States
Appointments
Cardiovascular Medicine
Primary
Titles
Clinician
Contact Info
Cardiovascular Medicine
175 Sherman Ave, 6th floor
New Haven, CT 06511
United States
Appointments
Cardiovascular Medicine
Primary
Titles
Clinician
Contact Info
Cardiovascular Medicine
175 Sherman Ave, 6th floor
New Haven, CT 06511
United States
About
Titles
Assistant Professor of Medicine (Cardiovascular Medicine)
ClinicianAppointments
Cardiovascular Medicine
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Fellowship
- Tufts University School of Medicine (2011)
- Fellowship
- Hospital of St. Raphael (2010)
- PhD
- Wesleyan University (2006)
- Residency
- Hospital of St. Raphael (2006)
- Intership
- Hospital of St. Raphael (2004)
- MD
- Carol Davila University of Medicine (1999)
Research
Overview
Platelets play a central role in atherosclerosis and treatment relies in anti-platelet therapies. However, there are different clinical phenotypes of atherosclerosis. Combining basic and clinical research approach to various clinical phenotypes, we are investigating the roles of platelets in coronary and peripheral vascular disease.
ORCID
0000-0003-2633-5450
Research at a Glance
Yale Co-Authors
Frequent collaborators of Costin Ionescu's published research.
Publications Timeline
A big-picture view of Costin Ionescu's research output by year.
Carlos Mena-Hurtado, MD, FACC, FSCAI, FAHA
Kim Germaine Emiel Smolderen, PhD, MSc
Christopher Regan, MD, FACC, FSCAI
Alan Dardik, MD/PhD, FACS, DFSVS, FAHA
Amenuve Bekui, MD, MPH
Britt Tonnessen, MD
11Publications
285Citations
Publications
2024
Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach.
Regan C, Scierka L, Dardik A, Tonnessen B, Iyad Ochoa Chaar C, Ionescu C, Aboian E, Cardella J, Nassiri N, Guzman R, Attaran R, Nagpal S, Shah S, Smolderen K, Mena-Hurtado C. Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach. Vascular 2024, 17085381241246318. PMID: 38669051, DOI: 10.1177/17085381241246318.Peer-Reviewed Original ResearchAltmetricConceptsDual antiplatelet therapyPeripheral arterial diseaseCYP2C19 testingCYP2C19 mutationsHeterogeneity of treatment effectsPeripheral vascular interventionsConsensus statementKnowledge questionsAntiplatelet therapyGenetic testingVascular surgeryAcademic health systemBarriers to implementationInterquartile rangeCYP2C19 genotype testingVascular diseaseInterventional cardiologyModified Delphi methodPatient's metabolic statusManagement of patientsCritical limb ischemiaPerceived barriersPeripheral vascular diseaseArterial vascular diseaseClinician perspectives
2023
Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults
Lee M, Smolderen K, Ionescu C, Hillegass W, Romain G, Mena-Hurtado C. Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults. Vascular Medicine 2023, 28: 197-204. PMID: 37293738, DOI: 10.1177/1358863x231151729.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPeripheral artery diseaseAbnormal ABILower extremity symptomsNormal ABILeg symptomsHigh riskBlack adultsExtremity symptomsStepwise Cox proportional hazards modelKaplan-Meier survival curvesCox proportional hazards modelAnkle-brachial indexFramingham risk factorsJackson Heart StudyProportional hazards modelCardiovascular outcomesCause mortalityArtery diseaseAsymptomatic diseaseAdverse outcomesMean ageSymptom assessmentAsymptomatic participantsRisk factorsSymptomatic participants
2020
Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease
Anantha-Narayanan M, Sheikh AB, Nagpal S, Jelani QU, Smolderen KG, Regan C, Ionescu C, Ochoa Chaar CI, Schneider M, Llanos-Chea F, Mena-Hurtado C. Systematic review and meta-analysis of outcomes of lower extremity peripheral arterial interventions in patients with and without chronic kidney disease or end-stage renal disease. Journal Of Vascular Surgery 2020, 73: 331-340.e4. PMID: 32889074, DOI: 10.1016/j.jvs.2020.08.032.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCKD/end-stage renal diseaseEnd-stage renal diseaseNormal renal functionChronic kidney diseaseTarget lesion revascularizationLong-term mortalityPeripheral arterial diseaseRenal functionPAD interventionsMajor amputationRenal diseaseKidney diseaseOdds ratioNormal renal function groupIntervention typeRenal function groupCritical limb ischemiaPeripheral arterial interventionsConfidence intervalsPooled odds ratioOpen surgical approachMultivariable regression analysisCase-control matchingRandom-effects modelEvidence-based strategies
2019
Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients
Jain K, Tyagi T, Patell K, Xie Y, Kadado AJ, Lee SH, Yarovinsky T, Du J, Hwang J, Martin KA, Testani J, Ionescu CN, Hwa J. Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients. EBioMedicine 2019, 44: 28-40. PMID: 31130473, PMCID: PMC6604369, DOI: 10.1016/j.ebiom.2019.05.022.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdaptation, PhysiologicalAge FactorsAgedAged, 80 and overAgingAnimalsAntioxidantsApoptosisBiomarkersBlood PlateletsCardiovascular DiseasesComorbidityDisease Models, AnimalFemaleHomeostasisHumansMaleMiceMiddle AgedOxidation-ReductionOxidative StressPlatelet ActivationPlatelet AdhesivenessReactive Oxygen SpeciesRisk AssessmentRisk FactorsConceptsRisk patientsMouse studiesPlatelet phenotypeMajor adverse cardiovascular eventsHigh cardiovascular risk patientsAdaptive increaseAdverse cardiovascular eventsCentral pathophysiological roleCVD risk patientsCardiovascular risk patientsAggressive antiplatelet therapyEffect of comorbidityAge group 40Young healthy subjectsAntiplatelet therapyCardiovascular eventsYear age cohortAdvanced ageCVD patientsGroup 40Healthy subjectsPathophysiological roleElderly populationCardiovascular pathologyPatientsAntiplatelet therapy for tibial balloon angioplasty: A clinical perspective
Ionescu CN, Altin SE, Mena-Hurtado C. Antiplatelet therapy for tibial balloon angioplasty: A clinical perspective. SAGE Open Medicine 2019, 7: 2050312119854579. PMID: 31210934, PMCID: PMC6545680, DOI: 10.1177/2050312119854579.Peer-Reviewed Original ResearchConceptsTibial balloon angioplastyCritical limb ischaemiaBalloon angioplastyAntiplatelet therapyLimb ischaemiaCritical limb ischaemia patientsNumber of patientsMultiple comorbiditiesPreclinical dataAngioplasty techniquesTherapeutic approachesHigh riskPost interventionAngioplastyClinical perspectiveTherapyIschaemiaPatientsShort durationComorbiditiesTrialsImportant role
2015
Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1109 Patients
Pelliccia F, Parodi G, Greco C, Antoniucci D, Brenner R, Bossone E, Cacciotti L, Capucci A, Citro R, Delmas C, Guerra F, Ionescu CN, Lairez O, Larrauri-Reyes M, Lee PH, Mansencal N, Marazzi G, Mihos CG, Morel O, Nef HM, Gil I, Passaseo I, Pineda AM, Rosano G, Santana O, Schneck F, Song BG, Song JK, Teh AW, Ungprasert P, Valbusa A, Wahl A, Yoshida T, Gaudio C, Kaski JC. Comorbidities Frequency in Takotsubo Syndrome: An International Collaborative Systematic Review Including 1109 Patients. The American Journal Of Medicine 2015, 128: 654.e11-654.e19. PMID: 25660245, DOI: 10.1016/j.amjmed.2015.01.016.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTakotsubo syndromeCollaborative systematic reviewSystematic reviewRisk factorsInternational collaborative systematic reviewCardiovascular risk factorsChronic kidney diseaseComorbidities of patientsClinical characteristicsCommon comorbiditiesPulmonary diseaseKidney diseaseCumulative prevalenceThyroid diseaseComorbidity frequencyNeurologic diseaseRelevant prevalenceIndependent reviewersNineteen studiesComorbiditiesPatientsSyndromeEmotional stressorsDiseaseRelevant studies
2014
Prospective chest pain evaluation in the emergency department with use of high-sensitivity C-reactive protein (PROCEED-CRP study).
Ionescu CN, Chrissoheris MP, Slim HB, Slade M, Oen-Hsiao J, Donohue TJ, Bekui A, Ghantous AE. Prospective chest pain evaluation in the emergency department with use of high-sensitivity C-reactive protein (PROCEED-CRP study). Connecticut Medicine 2014, 78: 133-8. PMID: 24772828.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsHigh-sensitivity C-reactive proteinC-reactive proteinAcute myocardial infarctionEmergency departmentCause rehospitalizationChest painMyocardial infarctionChest pain evaluationCoronary revascularizationHs-CRPConsecutive patientsFinal cohortPain evaluationMyocardial ischemiaClinical valuePatientsRehospitalizationPainInfarctionDepartmentDaysRevascularizationIschemiaCohortCRP
2011
Left ventricular noncompaction and aneurysm revealed by left ventriculography
Ionescu CN, Turcot D. Left ventricular noncompaction and aneurysm revealed by left ventriculography. Catheterization And Cardiovascular Interventions 2011, 80: 109-111. PMID: 21954168, DOI: 10.1002/ccd.23322.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAnticoagulantsCardiac CatheterizationDefibrillators, ImplantableEchocardiographyElectric CountershockElectrocardiography, AmbulatoryHeart AneurysmHeart VentriclesHumansIsolated Noncompaction of the Ventricular MyocardiumMaleMiddle AgedPredictive Value of TestsRadiographyStroke VolumeTachycardia, VentricularVentricular Function, LeftWarfarinConceptsLeft ventriculographyCardiac catheterizationNoninvasive testsVentricular noncompactionNonobstructive coronary artery diseaseCoronary artery diseaseLeft ventricular aneurysmLeft ventricular noncompactionArtery diseaseEjection fractionVentricular aneurysmRare caseCatheterizationNoncompactionVentriculographyAneurysmsPatientsDisease
2010
Unexpected massive myocardial calcification
Ionescu C, Marcu C. Unexpected massive myocardial calcification. Netherlands Heart Journal 2010, 1-5. DOI: 10.1007/s12471-010-0009-9.Peer-Reviewed Original ResearchTreatment and outcomes of nonagenarians with ST-elevation myocardial infarction.
Ionescu CN, Amuchastegui M, Ionescu S, Marcu CB, Donohue T. Treatment and outcomes of nonagenarians with ST-elevation myocardial infarction. Journal Of Invasive Cardiology 2010, 22: 474-8. PMID: 20944186.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsST-elevation myocardial infarctionPercutaneous coronary interventionReperfusion therapyMyocardial infarctionOutcome of nonagenariansMedical therapy groupAcute coronary syndromeMajority of patientsKaplan-Meier analysisProcedure-associated complicationsTreatment of patientsYears of ageHospital mortalityPCI groupCoronary syndromeCoronary interventionHospital dischargeOlder patientsSurvival benefitBetter prognosisCurrent guidelinesTherapy groupLower incidenceRetrospective analysisPatients
Academic Achievements and Community Involvement
activity Associate Editor
Journal ServiceJournal of Clinical and Experimental CardiologyDetails2013 - Presentactivity Associate Editor
Journal ServiceClinical Medicine Insights: CardiologyDetails2014 - Presentactivity Member
CommitteesYale New Haven HospitalDetails2015 - PresentDescription1. Medical Council Leadership 2. Readmission Reduction Initiativeactivity Intra-Aortic balloon pump counterpulsation use in acute coronary syndromes complicated by cardiogenic shock has no effect on in-hospital mortality
Oral PresentationIntra-Aortic balloon pump counterpulsation use in acute coronary syndromes complicated by cardiogenic shock has no effect on in-hospital mortalityDetails01/01/2012 - PresentVancouver, BC, CanadaSponsored by World Congress on Heart Disease
Clinical Care
Overview
Clinical Specialties
Cardiovascular Medicine; Interventional Cardiology
Fact Sheets
Angina
Learn More on Yale MedicineCoronary Artery Disease (CAD)
Learn More on Yale MedicineCoronary Atherosclerosis Treatments
Learn More on Yale MedicineCT Scan for Coronary Artery Disease
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Board Certifications
Interventional Cardiology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2011
Cardiovascular Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2010
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Cardiovascular Medicine
175 Sherman Ave, 6th floor
New Haven, CT 06511
United States
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