Catherine Yeckel, PhD
Senior Lecturer of Epidemiology (Environmental Health Sciences)Cards
Contact Info
Environmental Health Sciences
PO Box 208034, 60 College Street
New Haven, CT 06520-8034
United States
About
Titles
Senior Lecturer of Epidemiology (Environmental Health Sciences)
Biography
Catherine Weikart Yeckel, MS, Ph.D. is an Assistant Clinical Professor. She received a master’s degree in exercise physiology from the University of Pittsburgh and a doctoral degree from University of Texas Medical Branch (UTMB)-Galveston in preventive medicine and community health in the areas of human metabolism and nutrition. In collaboration with researchers at UTMB-Galveston, and more recently with researchers and clinicians specializing in pediatric and adult endocrinology at the Yale School of Medicine, she focused her research interests along the spectrum of insulin resistance and ß-cell dysfunction. These interests broadly include cardiometabolic health issues and protection as a consequence of obesity from young to old age, and physical activity/fitness from sedentary to physically fit. She has used physiological challenge models to unmask the impact of arsenic exposure on blood pressure (stress) hyperreactivity, and most recently, to help innovate imaging for brown adipose tissue metabolism in human. Dr. Yeckel created and directs an integrative course for YSPH, Physiology of Public Health. She also initiated and co-directed The Art of Public Health workshops involving MPH and MA student match-ups between YSPH and YSA. She serves as a reviewer/scientific advisor and consultant for diverse entities, including government agencies, museums and companies.
Appointments
Environmental Health Sciences
Senior LecturerPrimary
Other Departments & Organizations
- Environmental Health Sciences
- Obesity Research Working Group
- Yale School of Public Health
- Yale School of Public Health - NEW
- Yale Ventures
Education & Training
- PhD
- University of Texas at Galveston (2001)
- MS
- University of Pittsburgh (1992)
- BA
- Oberlin College (1983)
Research
Overview
- Maximal exercise recovery as a model for insulin resistance and beta-cell function.
- Mild cold and PET-imaging to examine the norepinephine reuptake transporter in human brown adipose tissue
- Cardiovascular risk from exposure to inorganic arsenic in drinking water
- Inter-individual differences in inorganic arsenic metabolic partitioning and low birth weight outcome.
- Collaboration (animal model): Integration nutrient sensing pathways
Medical Research Interests
Public Health Interests
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
James Dziura, MPH, PhD
William Tamborlane, MD
Barbara Gulanski, MD, MPH
Jean-Dominique Gallezot, PhD
Insulin Resistance
Obesity
Adipose Tissue, Brown
Metabolic Syndrome
Publications
2023
1541-P: Sympathetic Nervous System Activity in Response to Food Ingestion Is Impacted by Obesity
CHUNG T, DEAJON-JACKSON J, BINI J, SONG H, SANCHEZ RANGEL E, YECKEL C, HWANG J, STACHENFELD N, BELFORT-DEAGUIAR R. 1541-P: Sympathetic Nervous System Activity in Response to Food Ingestion Is Impacted by Obesity. Diabetes 2023, 72 DOI: 10.2337/db23-1541-p.Peer-Reviewed Original ResearchConceptsSympathetic nervous system activityMuscle sympathetic nerve activityMixed meal testNormal weightNervous system activityDistribution volume ratioPET-CTHeart rateSympathetic nerve activitySystem activityIngestion of foodMSNA increasesEndogenous NEMeal testNE releaseNerve activityOB subjectsObesity altersKidney diseaseDeltoid muscleLean individualsOB individualsNE transporterObeseFood ingestion
2018
Glycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 Diabetes
ELSHAFIE A, LAM W, PARIKH L, RANGEL E, SCHMIDT C, HWANG J, YECKEL C, SHERWIN R, BELFORT-DEAGUIAR R. Glycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 Diabetes. Diabetes 2018, 67 DOI: 10.2337/db18-82-lb.Peer-Reviewed Original ResearchConceptsGlucose infusion rateInsulin secretion-sensitivity index-2Beta-cell functionContinuous overlapping net glycemic actionGlucose variabilityContinuous glucose monitorT2D subjectsObese subjectsInsulin levelsGV indicesGlucose metabolismCell functionInsulin sensitivity indexType 2 diabetesGlycemic Risk AssessmentCGM indicesHealthy obesityMannKind CorporationHealthy obeseOB subjectsGlycemic excursionsInsulin resistanceIncremental AUCGlycemic variabilityRegeneron Pharmaceuticals
2013
Blood pressure hyperreactivity
Kunrath J, Gurzau E, Gurzau A, Goessler W, Gelmann ER, Thach TT, McCarty KM, Yeckel CW. Blood pressure hyperreactivity. Journal Of Hypertension 2013, 31: 361-369. PMID: 23203141, PMCID: PMC3542419, DOI: 10.1097/hjh.0b013e32835c175f.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBlood pressure hyperreactivityBlood pressure recoveryHypertensive responseUnexposed groupMiddle-aged menCold pressor testInorganic arsenic exposureInorganic arsenicCardiovascular stress reactivityNormotensive menBlood pressureEssential hypertensionHypertension riskPressor testHyperreactivityChronic exposureArsenic exposureArsenic-endemic regionEarly signsStress-induced changesFunctional evaluationUrine samplesDrinking waterStress reactivityGreater probability
2012
Ex Vivo and In Vivo Evaluation of the Norepinephrine Transporter Ligand [11C]MRB for Brown Adipose Tissue Imaging
Lin SF, Fan X, Yeckel CW, Weinzimmer D, Mulnix T, Gallezot JD, Carson RE, Sherwin RS, Ding YS. Ex Vivo and In Vivo Evaluation of the Norepinephrine Transporter Ligand [11C]MRB for Brown Adipose Tissue Imaging. Nuclear Medicine And Biology 2012, 39: 1081-1086. PMID: 22595487, PMCID: PMC4067762, DOI: 10.1016/j.nucmedbio.2012.04.005.Peer-Reviewed Original ResearchCitationsMeSH Keywords and Concepts
2011
Skeletal Muscle Nonnutritive Blood Flow Increases in Response to a Sit‐to‐Stand Orthostatic Challenge
Yeckel C, Castillo M, Gosselin M, Gulanski B. Skeletal Muscle Nonnutritive Blood Flow Increases in Response to a Sit‐to‐Stand Orthostatic Challenge. The FASEB Journal 2011, 25: 814.12-814.12. DOI: 10.1096/fasebj.25.1_supplement.814.12.Peer-Reviewed Original ResearchConceptsMuscle blood flowBlood flowOrthostatic challengeVenous occlusionInitial hemodynamic responseMuscle contraction conditionsBlood flow increasesMuscle oxygen consumptionOxygen consumption responsesYoung healthy participantsVenous returnMuscle totalHemodynamic responseCalf musclesHealthy participantsOxygen consumptionOcclusionRight posturePhysiological challengesFlow increasesContraction controlResponseControlBloodContraction conditions
2009
Specific Relation Between Abdominal Obesity and Early-Phase Hyperglycemia Is Modulated by Hepatic Insulin Resistance in Healthy Older Women
DiPietro L, Dziura J, Yeckel CW. Specific Relation Between Abdominal Obesity and Early-Phase Hyperglycemia Is Modulated by Hepatic Insulin Resistance in Healthy Older Women. Diabetes Care 2009, 33: 165-167. PMID: 19808930, PMCID: PMC2797964, DOI: 10.2337/dc09-1365.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsHepatic insulin resistanceOral glucose tolerance testAbdominal obesityGlucose tolerance testHealthy older womenInsulin resistanceOlder womenTolerance testLow-dose insulin infusionHepatic glucose productionGlucose excursionsInsulin infusionPlasma glucoseAbdominal circumferenceInsulin concentrationsInsulin suppressionMin postchallengeObesityGlycemic responseClamp techniqueGlucose productionWomenHyperglycemiaProduction suppressionPostchallenge
2007
Progressive Improvement in Glucose Tolerance with Light Resistance TVaining in Older Women
DiPietro L, Yeckel C, Dziura J. Progressive Improvement in Glucose Tolerance with Light Resistance TVaining in Older Women. Medicine & Science In Sports & Exercise 2007, 39: s288. DOI: 10.1249/01.mss.0000274112.76453.98.Peer-Reviewed Original ResearchMaximal exercise recovery as a potential means for assessing sympathetic overactivity related to insulin resistance
Yeckel C, Gulanski B, Lopes M, Dziura J, Parish R, Sherwin R. Maximal exercise recovery as a potential means for assessing sympathetic overactivity related to insulin resistance. The FASEB Journal 2007, 21: a575-a575. DOI: 10.1096/fasebj.21.5.a575.Peer-Reviewed Original ResearchConceptsSympathetic overactivityInsulin resistanceHeart rateWhole-body insulin sensitivity indexExercise heart rate recoveryHealthy young cohortMaximal fitness testInsulin sensitivity indexHeart rate recoveryAutonomic nervous systemInsulin sensitivity measurementsRecovery heart rateParasympathetic dysfunctionSympathetic withdrawalParasympathetic functionInsulin levelsMaximal exerciseExercise recoverySympathovagal balanceCardiovascular diseaseRate recoveryNervous systemOveractivityFitness testsYounger cohorts
2006
Exercise and Improved Insulin Sensitivity in Older Women: Evidence of the Enduring Benefits of Higher Intensity Training.
DiPietro L, Dziura J, Yeckel C, Neufer P. Exercise and Improved Insulin Sensitivity in Older Women: Evidence of the Enduring Benefits of Higher Intensity Training. Cardiopulmonary Physical Therapy Journal 2006, 17: 95. DOI: 10.1097/01823246-200617020-00011.Peer-Reviewed Original Research
2005
Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training
DiPietro L, Dziura J, Yeckel CW, Neufer PD. Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. Journal Of Applied Physiology 2005, 100: 142-149. PMID: 16141382, DOI: 10.1152/japplphysiol.00474.2005.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHigh-intensity exercise trainingIntensity exercise trainingExercise trainingAerobic trainingInsulin sensitivityExercise volumeOlder womenGlucose utilizationModerate-intensity aerobic trainingTwo-step euglycemic-hyperinsulinemic clampInsulin-stimulated glucose utilizationHigh-intensity aerobic trainingDual-energy X-ray absorptiometryHigher insulin doseLower insulin doseHealthy older womenEuglycemic hyperinsulinemic clampLow-intensity exerciseTotal body fatAdipose tissue lipolysisImproved glucose utilizationX-ray absorptiometrySuppression of lipolysisFinal exercise boutInsulin-stimulated suppression
Academic Achievements & Community Involvement
activity Cardiovascular risk in Romania
ResearchDetails01/01/2009 - PresentRomaniaAbstract/SynopsisExamination of blood pressure reactivity to cold pressor test in region of low-to-moderate inorganic arsenic in drinking water.
activity Low birth weight in Romania
ResearchDetails01/01/2009 - PresentRomaniaAbstract/SynopsisEffects of inter-individual differences in inorganic arsenic metabolism on low birth weight outcome
News
News
- August 23, 2022
Longtime public health professional Vanessa Lamers speaks to the value of an MPH degree
- March 23, 2016Source: Oglethorpe University
“YALE UNIVERSITY’S THE ART OF PUBLIC HEALTH” INSPIRES OGLETHORPE BIOLOGY STUDENTS
- March 16, 2016
The Art of Public Health to Open in Atlanta
- May 14, 2014
The Art of Public Health
Get In Touch
Contacts
Environmental Health Sciences
PO Box 208034, 60 College Street
New Haven, CT 06520-8034
United States
Locations
135 College Street
Academic Office
Ste 200
New Haven, CT 06510