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Smita Krishnaswamy, PhD

Associate Professor of Genetics and of Computer Science

Contact Information

Smita Krishnaswamy, PhD

Mailing Addresses

  • Yale School of Medicine

    100 College Street

    New Haven, CT 06510

    United States

  • Computer Science

    17 Hillhouse Avenue

    New Haven, CT 06511

    United States



Smita Krishnaswamy is an Associate professor in Genetics and Computer Science. She is affiliated with the applied math program, computational biology program, Yale Center for Biomedical Data Science and Yale Cancer Center. Her lab works on the development of machine learning techniques to analyze high dimensional high throughput biomedical data. Her focus is on unsupervised machine learning methods, specifically manifold learning and deep learning techniques for detecting structure and patterns in data. She has developed algorithms for non-linear dimensionality reduction and visualization, learning data geometry, denoising, imputation, inference of multi-granular structure, and inference of feature networks from big data. Her group has applied these techniques to many data types such as single cell RNA-sequencing, mass cytometry, electronic health record, and connectomic data from a variety of systems. Specific application areas include immunology, immunotherapy, cancer, neuroscience, developmental biology and health outcomes. Smita has a Ph.D. in Computer Science and Engineering from the University of Michigan.

Education & Training

  • Postdoctoral Fellowship
    Columbia University (2015)
  • PhD
    University of Michigan (2008)
  • MS
    University of Michigan (2004)
  • BA
    Kalamazoo College, Mathematics (2002)
  • BS
    University of Michigan (2002)

Honors & Recognition

AwardAwarding OrganizationDate
Excellence in Science Early-Career Investigator AwardFederation of American Societies for Experimental Biology (FASEB)2022

Departments & Organizations