Publications

2025

Divergent proteome tolerance against gain and loss of chromosome arms.
Di Y, Li W, Castellano JJ, Jin W, Modi JN, Salovska B, Khosroabadi D, Hu W, Taylor AM, Liu Y. Divergent proteome tolerance against gain and loss of chromosome arms. Mol Cell 2025, 85: 4268-4278.e6. PMID: 41270725, DOI: 10.1016/j.molcel.2025.10.023.
Peer-Reviewed Original Research
Sequential class switching generates antigen-specific gut IgA from IgG1 B cells
Siniscalco E, Meng H, Gabernet G, Pacheco G, Saghaei S, Ramirez S, Hills L, Faraji F, Chen S, Yin X, Dien C, Hoyt L, Liu E, Barrett A, Briggs N, Williams A, Shukla V, Crotty S, Wesemann D, Kleinstein S, Craft J, Eisenbarth S. Sequential class switching generates antigen-specific gut IgA from IgG1 B cells. Immunity 2025 PMID: 41253159, DOI: 10.1016/j.immuni.2025.10.022.
Peer-Reviewed Original Research
This study investigates how gut-specific IgA antibodies are generated from IgG1 B cells through sequential class switching, highlighting a crucial mechanism for designing effective mucosal vaccines.
Full Summary
Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors
Karatepe K, de Faria B, Zhang J, Chen X, Pinto H, Fyodorov D, Sefik E, Willcockson M, Flavell R, Skoultchi A, Guo S. Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2509412122. PMID: 41118213, PMCID: PMC12582276, DOI: 10.1073/pnas.2509412122.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Safety and effectiveness of statins in hospitalized patients with COVID-19: Systematic review and collaborative meta-analysis of randomized controlled trials
Ortega-Paz L, Talasaz A, Sadeghipour P, Rashedi S, Connors J, Angiolillo D, Cavallari L, Jimenez D, Bastidas G, Lorenzi E, Berry L, Hills T, McAuley D, Shah T, Lansky A, Deepti S, Gaitán-Duarte H, Potpara T, Galli M, Dixon D, Piazza G, Lip G, Mehran R, Libby P, Krumholz H, Bikdeli B. Safety and effectiveness of statins in hospitalized patients with COVID-19: Systematic review and collaborative meta-analysis of randomized controlled trials. Thrombosis Research 2025, 255: 109484. PMID: 40992230, DOI: 10.1016/j.thromres.2025.109484.
Peer-Reviewed Original Research
Concepts
Sclerotic GVHD and Scleroderma Share Dysregulated Gene Expression that is Ameliorated by EREG Therapeutic Antibody
Newton N, Agrawal K, Odell A, Tracy T, Hackett C, Eldrup A, Whitfield M, Martyanov V, Girardi M, Sefik E, Flavell R, Odell I. Sclerotic GVHD and Scleroderma Share Dysregulated Gene Expression that is Ameliorated by EREG Therapeutic Antibody. Blood 2025 PMID: 40961242, DOI: 10.1182/blood.2025029836.
Peer-Reviewed Original Research
Concepts
Humanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow.
Sefik E, Philbrick W, Zhang F, Agrawal K, Van Lee B, Sam J, Karatepe K, Zheng Y, Liang K, Peng S, Mirza H, Rangavajhula A, Simon P, Arun N, Babu P, Eynon E, Chiorazzi M, Shan L, Halene S, Luo H, Rongvaux A, Kluger Y, Flavell R. Humanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2426546122. PMID: 40956886, PMCID: PMC12478129, DOI: 10.1073/pnas.2426546122.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Clinical effectiveness of HPV vaccine by age at vaccination: a matched case-control study
Oliveira C, Shapiro E, Sheth S, Ellingson M, Johnson N, Sullivan E, Querec T, Unger E, Niccolai L. Clinical effectiveness of HPV vaccine by age at vaccination: a matched case-control study. The Lancet Regional Health - Americas 2025, 51: 101225. PMID: 41019517, PMCID: PMC12465035, DOI: 10.1016/j.lana.2025.101225.
Peer-Reviewed Original Research
Concepts
Innate immune molecular landscape following controlled human influenza virus infection
Thistlethwaite W, Vangeti S, Cheng W, Agarwal P, Cappuccio A, Wang W, Wei B, Myers R, Rubenstein A, Chawla D, Hariharan M, McClain M, Burke T, Kleinstein S, Ecker J, Woods C, Greenleaf W, Chen X, Ramos I, Zaslavsky E, Evans T, Troyanskaya O, Sealfon S. Innate immune molecular landscape following controlled human influenza virus infection. Cell Reports 2025, 44: 116312. PMID: 40966076, DOI: 10.1016/j.celrep.2025.116312.
Peer-Reviewed Original Research
Concepts
Approach to the Postmarket Evaluation of Consumer Wearable Technologies
Pundi K, Bhavnani S, Seninger C, Zuckerman B, Paulsen J, Aguel F, Din N, Viggiano B, Yoo R, Dalal N, Go A, Granger C, Krumholz H, Lacar K, Li R, Lin S, Mahaffey K, Mahoney M, McCall D, Hills M, Harrington R, Hernandez-Boussard T, Saha A, Shah N, Turakhia M. Approach to the Postmarket Evaluation of Consumer Wearable Technologies. JAMA Cardiology 2025, 10 PMID: 40928810, DOI: 10.1001/jamacardio.2025.3006.
Peer-Reviewed Original Research
Concepts
A multi-omics recovery factor predicts long COVID in the IMPACC study
Gabernet G, Maciuch J, Gygi J, Moore J, Hoch A, Syphurs C, Chu T, Jayavelu N, Corry D, Kheradmand F, Baden L, Sekaly R, McComsey G, Haddad E, Cairns C, Rouphael N, Fernandez-Sesma A, Simon V, Metcalf J, Higuita N, Hough C, Messer W, Davis M, Nadeau K, Pulendran B, Kraft M, Bime C, Reed E, Schaenman J, Erle D, Calfee C, Atkinson M, Brakenridge S, Melamed E, Shaw A, Hafler D, Augustine A, Becker P, Ozonoff A, Bosinger S, Eckalbar W, Maecker H, Kim-Schulze S, Steen H, Krammer F, Westendorf K, Network I, Peters B, Fourati S, Altman M, Levy O, Smolen K, Montgomery R, Diray-Arce J, Kleinstein S, Guan L, Ehrlich L. A multi-omics recovery factor predicts long COVID in the IMPACC study. Journal Of Clinical Investigation 2025 PMID: 40924481, DOI: 10.1172/jci193698.
Peer-Reviewed Original Research
Concepts
CSF immune cell alterations in women with neuropsychiatric Long COVID
Orlinick B, Mehta S, McAlpine L, Khoshbakht S, Fertuzinhos S, Nelson A, Chiarella J, Das B, Patel V, Filippidis P, Corley M, Spudich S, Farhadian S. CSF immune cell alterations in women with neuropsychiatric Long COVID. The Journal Of Infectious Diseases 2025, jiaf468. PMID: 40920586, DOI: 10.1093/infdis/jiaf468.
Peer-Reviewed Original Research
Concepts
Topography and environmental deficiencies are associated with chikungunya virus exposure in urban informal settlements in Salvador, Brazil
Travis C, Argibay H, Pellizzaro M, de Oliveira D, Santana R, Palma F, Lustosa R, Santana J, Souza F, López Y, Reis M, Ko A, Diggle P, Ribeiro G, Begon M, Costa F, Khalil H, Eyre M. Topography and environmental deficiencies are associated with chikungunya virus exposure in urban informal settlements in Salvador, Brazil. PLOS Neglected Tropical Diseases 2025, 19: e0013477. PMID: 40911655, PMCID: PMC12440227, DOI: 10.1371/journal.pntd.0013477.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Moving Beyond the Model Our Perspective on Meaningful AI Research in Cardiovascular Care
Jain S, Mortazavi B, Chan You S, Yao X, Lam C, Elias P, Poterucha T, Avram R, Tison G, Pirruccello J, Huang C, Wiens J, Schwamm L, Ruan X, Dunn J, Luo Y, Spatz E, Krumholz H. Moving Beyond the Model Our Perspective on Meaningful AI Research in Cardiovascular Care. Journal Of The American College Of Cardiology 2025, 86: 691-695. PMID: 40903130, DOI: 10.1016/j.jacc.2025.07.040.
Peer-Reviewed Original Research
Network-based modeling of emotional expressions for multiple cancers via a linguistic analysis of an online health community
Fan X, Liu M, Ma S. Network-based modeling of emotional expressions for multiple cancers via a linguistic analysis of an online health community. The Annals Of Applied Statistics 2025, 19: 2218-2236. DOI: 10.1214/25-aoas2047.
Peer-Reviewed Original Research
Concepts
A Tad Bit of Extra Clarity About Clots: Why JACC Took Interest in TADCLOT
Bikdeli B, Cohen D, Bittl J, Krumholz H. A Tad Bit of Extra Clarity About Clots: Why JACC Took Interest in TADCLOT. Journal Of The American College Of Cardiology 2025 PMID: 40892618, DOI: 10.1016/j.jacc.2025.08.049.
Peer-Reviewed Original Research
How PARTHENOPE Charts the Course Toward Precision DAPT: Navigating Future Science in Antiplatelet Therapy
You S, Bikdeli B, Lin Z, Bittl J, Cohen D, Krumholz H. How PARTHENOPE Charts the Course Toward Precision DAPT: Navigating Future Science in Antiplatelet Therapy. Journal Of The American College Of Cardiology 2025 PMID: 40892615, DOI: 10.1016/j.jacc.2025.08.045.
Peer-Reviewed Original Research
Zika in Infants and Pregnancy (ZIP) study: results from a prospective international cohort study of prenatal Zika virus infection and adverse fetal and infant outcomes
Lebov J, Nason M, Stolka K, Ximenes R, Mussi-Pinhata M, Moye J, Zorrilla C, Velez Vega C, Cordero J, Scalabrin D, Ko A, Moreira M, Galvão L, Britt W, Marques E, Balmaseda A, Harris E, Arias J, Schultz-Cherry S, Garces A, Krebs N, Ochoa T, Ugarte-Gil C, Fogleman E, Gabriel E, Welton M, Irizarry C, de Moura Negrini S, Coutinho C, de Barros Miranda-Filho D, Montarroyos U, Cordeiro M, Gajewski A, Osorio J, Figueroa L. Zika in Infants and Pregnancy (ZIP) study: results from a prospective international cohort study of prenatal Zika virus infection and adverse fetal and infant outcomes. BMC Pregnancy And Childbirth 2025, 25: 903. PMID: 40885911, PMCID: PMC12399002, DOI: 10.1186/s12884-025-07774-y.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
GE-IA-NAM: gene–environment interaction analysis via imaging-assisted neural additive model
Li J, Xu Y, Ma S, Fang K. GE-IA-NAM: gene–environment interaction analysis via imaging-assisted neural additive model. Bioinformatics 2025, 41: btaf481. PMID: 40880282, PMCID: PMC12452269, DOI: 10.1093/bioinformatics/btaf481.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Self-reported Data From the LISTEN Study
AL Mouslmani M, Sawano M, Arun A, Wu Y, Shah R, Kaleem S, Zhou T, Murugiah K, Lu Y, Herrin J, Bishop P, Taub P, Peixoto A, Bhattacharjee B, Iwasaki A, Krumholz H. Characterization of Postural Orthostatic Tachycardia Syndrome in Long COVID Self-reported Data From the LISTEN Study. JACC Advances 2025, 4: 101873. PMID: 40883051, PMCID: PMC12399260, DOI: 10.1016/j.jacadv.2025.101873.
Peer-Reviewed Original Research
Concepts
Reply to McMahon et. al
Watkins T, Brockhurst J, Germain G, Foxman E. Reply to McMahon et. al. The Journal Of Infectious Diseases 2025, jiaf441. PMID: 40857606, DOI: 10.1093/infdis/jiaf441.
Peer-Reviewed Original Research
Human monoclonal antibodies targeting A35 protect from death caused by mpox.
Fantin RF, Yuan M, Park SC, Bozarth B, Cohn H, Ignacio M, Earl P, Civljak A, Laghlali G, Zhang D, Zhu X, Crandell J, Monteiro V, Clark JJ, Cotter C, Burkhardt M, Singh G, Warang P, García-Bernalt Diego J, Srivastava K, Lugo LA, Pischel L, PVI study group, Yildirim I, Omer SB, da Silva D, Krammer F, Bajic G, Simon V, Schotsaert M, Lucas C, Wilson IA, Moss B, Coelho CH. Human monoclonal antibodies targeting A35 protect from death caused by mpox. Cell 2025 PMID: 40865529, DOI: 10.1016/j.cell.2025.08.004.
Peer-Reviewed Original Research
A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity
Fang Z, Monteiro V, Oh C, Janabi K, Romero L, Ahsan N, Yang L, Peng L, DiMaio D, Lucas C, Chen S. A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity. Nature Biomedical Engineering 2025, 1-16. PMID: 40855125, DOI: 10.1038/s41551-025-01478-6.
Peer-Reviewed Original Research
Concepts
Arthropod adiponectin receptor-like proteins and microbial persistence
Guo Y, Wang Y, Yang Z, Fikrig E, Tang X. Arthropod adiponectin receptor-like proteins and microbial persistence. Trends In Parasitology 2025 PMID: 40858453, DOI: 10.1016/j.pt.2025.08.004.
Peer-Reviewed Original Research
Concepts
All-cause excess mortality associated with the Lāhainā, Maui fires
Nakatsuka M, Taparra K, Renton B, Chen A, Chen J, Krumholz H, Faust J. All-cause excess mortality associated with the Lāhainā, Maui fires. Frontiers In Climate 2025, 7: 1611198. DOI: 10.3389/fclim.2025.1611198.
Peer-Reviewed Original Research
Concepts
The role of complement in long COVID pathogenesis
Bayarri-Olmos R, Bain W, Iwasaki A. The role of complement in long COVID pathogenesis. JCI Insight 2025, 10: e194314. PMID: 40857408, PMCID: PMC12406719, DOI: 10.1172/jci.insight.194314.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

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