Aaron Wolfe, PhD
Associate Research ScientistAbout
Research
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2023
Erratum To: A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Simon M, Yang J, Gigas J, Earley E, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen S, Pope A, Van Meter M, Emmrich S, Firsanov D, Athreya A, Biashad S, Han J, Ryu S, Tare A, Zhu Y, Hudgins A, Atzmon G, Barzilai N, Wolfe A, Moody K, Garcia B, Robbins P, Vijg J, Seluanov A, Suh Y, Gorbunova V. Erratum To: A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. The EMBO Journal 2023, 42: embj2022113326. PMID: 36722290, PMCID: PMC9890223, DOI: 10.15252/embj.2022113326.Peer-Reviewed Original Research
2022
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Simon M, Yang J, Gigas J, Earley E, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen S, Pope A, Van Meter M, Emmrich S, Firsanov D, Athreya A, Biashad S, Han J, Ryu S, Tare A, Zhu Y, Hudgins A, Atzmon G, Barzilai N, Wolfe A, Moody K, Garcia B, Thomas D, Robbins P, Vijg J, Seluanov A, Suh Y, Gorbunova V. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. The EMBO Journal 2022, 41: embj2021110393. PMID: 36215696, PMCID: PMC9627671, DOI: 10.15252/embj.2021110393.Peer-Reviewed Original ResearchConceptsMono-ADP-ribosyl transferasesLamin A/CAshkenazi JewishSirtuin 6DNA double-strand break repairDouble-strand break repairImproving genome maintenanceAJ individualsGenome maintenanceGenome stabilityLINE1 retrotransposonsTarget sequenceBreak repairDeacetylase activityCellular pathwaysNAD+ concentrationMetabolic regulationLamin ACancer cellsKill cancer cellsHuman longevityAllelesRetrotransposonsGenomeDeacylase
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