Zeyan Liew, PhD, MPH
Associate Professor of Epidemiology (Environmental Health Sciences)DownloadHi-Res Photo
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Associate Professor of Epidemiology (Environmental Health Sciences)
Biography
Dr. Liew is an environmental and perinatal epidemiologist and a research methodologist. A core focus of his work is understanding how exposures that occur during critical and vulnerable periods of development may shape disease risks and influence health outcomes throughout our life span. Dr. Liew is leading numerous studies with funding from the NIH to evaluate whether fetal exposures to endocrine disrupting compounds and/or neurotoxicants could harm fetal brain development leading to neurological disorders or impaired neuropsychological function in childhood and young adulthood. He is also interested in methodological research, especially the development of novel study designs and analytical techniques that could help us better address biases in observational studies or research using “real-world” data.
Appointments
Environmental Health Sciences
Associate Professor on TermPrimary
Other Departments & Organizations
Education & Training
- Visiting Postdoc
- Aarhus University (2018)
- Visiting Scientist
- Harvard T.H. Chan School of Public Health (2016)
- PhD
- University of California, Los Angeles (UCLA), Epidemiology (2014)
- MPH
- University of California, Los Angeles (UCLA), Environmental Health Sciences (2011)
Research
Overview
Medical Research Interests
Acetaminophen; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Causality; Cerebral Palsy; Child Development; Endocrine Disruptors; Environmental Pollutants; Epilepsy; Models, Statistical; Pediatric Obesity; Pharmacoepidemiology; Pregnancy
Public Health Interests
Environmental Health; Epidemiology Methods; Global Health; Maternal & Child Health; Child/Adolescent Health; Perinatal/Prenatal Health; Pharmacoepidemiology
ORCID
0000-0002-9424-7869- View Lab Website
Yale Center for Perinatal, Pediatric and Environmental Epidemiology
Research at a Glance
Yale Co-Authors
Frequent collaborators of Zeyan Liew's published research.
Publications Timeline
A big-picture view of Zeyan Liew's research output by year.
Research Interests
Research topics Zeyan Liew is interested in exploring.
Jingyuan Xiao, MPH, BS, BA
Nicole Deziel, PhD, MHS
Pengfei Guo, MBBS, PhD
Haoran Zhuo
Joshua Warren, PhD
Katarzyna Chawarska, PhD
65Publications
1,539Citations
Pregnancy
Environmental Pollutants
Attention Deficit Disorder with Hyperactivity
Cerebral Palsy
Autism Spectrum Disorder
Acetaminophen
Publications
2024
Invited Perspective: Challenges and Opportunities in Evaluating the Effect of Chemical Mixtures on Congenital Chromosomal Abnormalities.
Liew Z, Guo P. Invited Perspective: Challenges and Opportunities in Evaluating the Effect of Chemical Mixtures on Congenital Chromosomal Abnormalities. Environmental Health Perspectives 2024, 132: 91301. PMID: 39258901, PMCID: PMC11389476, DOI: 10.1289/ehp15799.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsExposure range matters: considering non-linear associations in the meta-analysis of environmental pollutant exposure using examples of per- and polyfluoroalkyl substances and birth outcomes
Guo P, Warren J, Deziel N, Liew Z. Exposure range matters: considering non-linear associations in the meta-analysis of environmental pollutant exposure using examples of per- and polyfluoroalkyl substances and birth outcomes. American Journal Of Epidemiology 2024, kwae309. PMID: 39227151, DOI: 10.1093/aje/kwae309.Peer-Reviewed Original ResearchConceptsNon-linear associationMeta-analysisHeterogeneity of effect estimatesEffect estimatesPotential non-linear associationsExposure-outcome relationshipsRisk of preterm birthSubgroup meta-analysisBirth outcomesPollution exposureMeta-analytic approachMeta-analysesEffect sizeEnvironmental pollutant exposureResults heterogeneityExposure levelsHealth effectsPreterm birthEvidence-based policymakingPrenatal exposurePotential heterogeneityMean birth weightBirth weightMethodological challengesCut-off choiceQuantitative bias analysis methods for summary-level epidemiologic data in the peer-reviewed literature: a systematic review
Shi X, Liu Z, Zhang M, Hua W, Li J, Lee J, Dharmarajan S, Nyhan K, Naimi A, Lash T, Jeffery M, Ross J, Liew Z, Wallach J. Quantitative bias analysis methods for summary-level epidemiologic data in the peer-reviewed literature: a systematic review. Journal Of Clinical Epidemiology 2024, 175: 111507. PMID: 39197688, DOI: 10.1016/j.jclinepi.2024.111507.Peer-Reviewed Original ResearchAltmetricConceptsQuantitative bias analysis methodsQuantitative bias analysisPeer-reviewed literatureSystematic reviewEpidemiological dataObservational studyOpen Science FrameworkEnglish-language articlesWeb of ScienceMisclassification biasImpact of biasScience FrameworkStudy designEffect estimatesMeta-analysesPre-registeredStudy protocolBias analysisSelection biasLevel dataFuture investigationsMultiple biasesConfoundingReviewMEDLINEInvestigating Selection Bias in the Context of Multigenerational Cohort Study
Xiao J, Guo P, Li J, Liew Z. Investigating Selection Bias in the Context of Multigenerational Cohort Study. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0353.Peer-Reviewed Original ResearchMaternal Residential Mobility Between Pregnancies: A California Statewide Sibling Study
Bellia G, Zhuo H, Liew Z. Maternal Residential Mobility Between Pregnancies: A California Statewide Sibling Study. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0697.Peer-Reviewed Original ResearchPaternal and Maternal Exposures to Per- And Polyfluoroalkyl Substances and Child Behavioral Difficulties
Guo P, Luo J, Arah O, Toft G, Liew Z. Paternal and Maternal Exposures to Per- And Polyfluoroalkyl Substances and Child Behavioral Difficulties. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0321.Peer-Reviewed Original ResearchIs man the only animal with ears that cannot move them? Reflections on observational studies in obstetrics and gynecology
Pedersen L, Liew Z. Is man the only animal with ears that cannot move them? Reflections on observational studies in obstetrics and gynecology. Acta Obstetricia Et Gynecologica Scandinavica 2024, 103: 1478-1479. PMID: 39044537, PMCID: PMC11266722, DOI: 10.1111/aogs.14925.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsFamily history of psychiatric conditions and development of siblings of children with autism
Bellia G, Chang J, Liew Z, Vernetti A, Macari S, Powell K, Chawarska K. Family history of psychiatric conditions and development of siblings of children with autism. Autism Research 2024, 17: 1665-1676. PMID: 38896553, PMCID: PMC11341253, DOI: 10.1002/aur.3175.Peer-Reviewed Original ResearchAltmetricConceptsSiblings of childrenNeuropsychiatric disordersFamilies of childrenFamily history of schizophreniaYounger siblings of childrenHistory of psychiatric conditionsHistory of schizophreniaYounger siblingsAssess autism symptomsNonverbal IQAutism symptomsBipolar disorderIntellectual disabilityPsychiatric conditionsSubclinical symptomsAdaptive skillsSocial affectAdaptive functioningAutismFamily historyParent interviewsFamily factorsMultiple regression analysisDevelopmental outcomesDisordersAutism Spectrum Disorder and Grandmother’s Race, Ethnicity, and Nativity
Chow T, Meng Q, O’Sharkey K, Liew Z, Ritz B. Autism Spectrum Disorder and Grandmother’s Race, Ethnicity, and Nativity. JAACAP Open 2024 DOI: 10.1016/j.jaacop.2024.04.008.Peer-Reviewed Original ResearchConceptsIntellectual disabilityForeign-bornForeign-born whitesUS-born WhitesForeign-born blacksUS-born blacksForeign-born APIsUS-bornAsian-Pacific IslandersAutism spectrum disorderCalifornia DepartmentNativesGrandmothersPacific IslandersOdds ratioGrandchildrenEthnicityOffspring autism spectrum disorderRaceSelf-reported raceBirth certificatesMother-child pairsStudy investigated associationsWhitePublic healthMaternal intake of paracetamol during pregnancy and biomarkers of male fecundity in young adult sons
Laursen T, Ramlau-Hansen C, Tøttenborg S, Liew Z, Toft G, Gaml-Sørensen A, Hougaard K, Bonde J, Ernst A. Maternal intake of paracetamol during pregnancy and biomarkers of male fecundity in young adult sons. Reproductive Toxicology 2024, 127: 108626. PMID: 38815769, DOI: 10.1016/j.reprotox.2024.108626.Peer-Reviewed Original ResearchAltmetricConceptsIntake of paracetamolMaternal intakeHigher DNA fragmentation indexDanish National Birth CohortDNA fragmentation indexSemen characteristicsLong durationImpaired semen qualityConfidence intervalsImpaired semen characteristicsNational Birth CohortReproductive hormone levelsAssociated with biomarkersDuration of exposureYears of ageFetal programmingNo intakeImmotile spermatozoaSons of mothersFollow-upYoung adult menHormone levelsSemen qualityMale fecundityTrimester-specific
Academic Achievements & Community Involvement
activity Society for Epidemiologic Research (SER)
Professional OrganizationsMemberDetails2013 - Presentactivity International Society for Environmental Epidemiology (ISEE)
Professional OrganizationsMemberDetails2013 - Presentactivity Society for Pediatric and Perinatal Epidemiologic Research
Professional OrganizationsMemberDetails2015 - Presentactivity American Academy for Cerebral Palsy and Developmental Medicine
Professional OrganizationsMemberDetails2020 - Presenthonor Early Career Investigator Research Award
Yale University AwardYale School of Public HealthDetails05/22/2024
News & Links
News
- September 24, 2024
Zeyan Liew receives grants to study the role of PFAS in cerebral palsy
- May 23, 2024
2024 Top Research Awards Announced
- January 23, 2024
Investigating Maternal Inflammatory Arthritis and Pregnancy Outcomes
- April 03, 2023
Higher Lithium Levels in Drinking Water May Raise Autism Risk
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Yale Center for Perinatal, Pediatric and Environmental Epidemiology (CPPEE)
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1 Church Street
New Haven, CT 06510