Exploring the effects of cannabidiol on pain sensitivity using quantitative sensory testing among individuals receiving methadone or buprenorphine for opioid use disorder: an open-label, proof-of-concept study
Costa G, Suh R, Sofuoglu M, De Aquino J. Exploring the effects of cannabidiol on pain sensitivity using quantitative sensory testing among individuals receiving methadone or buprenorphine for opioid use disorder: an open-label, proof-of-concept study. Addictive Behaviors Reports 2026, 23: 100654. DOI: 10.1016/j.abrep.2025.100654.Peer-Reviewed Original Research
Quantitative sensory testingOpioid use disorderPain sensitivityUse disorderProof-of-concept studyCannabidiol's impactCBD doseOpen-labelChronic painPain managementQuantitative sensory testing measuresPlacebo-controlled randomized trialPain response patternsTolerability of cannabidiolHeat pain thresholdEffects of cannabidiolAdverse cognitive effectsOpioid use disorder treatmentSensory testingPain thresholdVerbal memorySubjective effectsCannabidiol doseAdverse eventsBuprenorphine group