2000
Activator of G protein signaling 3 is a guanine dissociation inhibitor for Gαi subunits
De Vries L, Fischer T, Tronchère H, Brothers G, Strockbine B, Siderovski D, Farquhar M. Activator of G protein signaling 3 is a guanine dissociation inhibitor for Gαi subunits. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 14364-14369. PMID: 11121039, PMCID: PMC18924, DOI: 10.1073/pnas.97.26.14364.Peer-Reviewed Original ResearchMeSH KeywordsAluminum CompoundsAmino Acid MotifsAmino Acid SequenceAnimalsCell FractionationFluoridesGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding ProteinsGuanineGuanine Nucleotide Dissociation InhibitorsGuanosine DiphosphateHeterotrimeric GTP-Binding ProteinsMolecular Sequence DataRatsTissue DistributionConceptsActivator of G-protein signaling 3Guanine dissociation inhibitorGDP-bound formHeterotrimeric G proteinsGoLoco motifDissociation inhibitorG-proteinHeterotrimeric G protein signalingRate of exchange of GDPTissue-specific alternative splicingSignaling 3Exchange of GDPFamily of proteinsG protein signalingGalpha(o) subunitsAlternative splicingBinding motifSignal transductionGalpha subunitsNorthern blottingPC-12 cellsGTPgammaS binding assaySubunitTryptophan fluorescenceBinding assaysModulation of Host Signaling by a Bacterial Mimic Structure of the Salmonella Effector SptP Bound to Rac1
Stebbins C, Galán J. Modulation of Host Signaling by a Bacterial Mimic Structure of the Salmonella Effector SptP Bound to Rac1. Molecular Cell 2000, 6: 1449-1460. PMID: 11163217, DOI: 10.1016/s1097-2765(00)00141-6.Peer-Reviewed Original ResearchMeSH KeywordsAluminum CompoundsAmino Acid SequenceAmino Acid SubstitutionBacterial ProteinsBinding Sitescdc42 GTP-Binding ProteinCrystallography, X-RayDimerizationEvolution, MolecularFluoridesGTPase-Activating ProteinsGuanosine DiphosphateMacromolecular SubstancesModels, MolecularMolecular Sequence DataMutationProtein BindingProtein Structure, SecondaryProtein Structure, TertiaryProtein Tyrosine Phosphatasesrac1 GTP-Binding ProteinRecombinant Fusion ProteinsSalmonella typhimuriumSequence AlignmentSignal Transduction
1993
Activated release of membrane-anchored TGF-alpha in the absence of cytosol
Bosenberg M, Pandiella A, Massagué J. Activated release of membrane-anchored TGF-alpha in the absence of cytosol. Journal Of Cell Biology 1993, 122: 95-101. PMID: 8314849, PMCID: PMC2119606, DOI: 10.1083/jcb.122.1.95.Peer-Reviewed Original ResearchMeSH KeywordsAluminumAluminum CompoundsAnimalsCell MembraneCell Membrane PermeabilityCHO CellsCricetinaeFluoridesFluorineGTP-Binding ProteinsGuanosine 5'-O-(3-Thiotriphosphate)Guanosine DiphosphateKineticsProtein Kinase CProtein PrecursorsProtein Processing, Post-TranslationalRatsRecombinant ProteinsTetradecanoylphorbol AcetateThionucleotidesTransfectionTransforming Growth Factor alphaConceptsMembrane-anchored growth factorsHeterotrimeric G proteinsCell surfaceIndependent protein kinase CCellular proteolytic systemsStreptolysin OProtein kinase CAbsence of cytosolVesicular trafficCytoplasmic tailATP hydrolysisProteolytic componentKinase CG proteinsProteolytic systemIntact cellsPermeabilized cellsGTP gamma SBiochemical componentsCytosolAlpha cleavageTGF-alphaRegulated systemGamma SGrowth factor
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