Activator of G protein signaling 3 is a guanine dissociation inhibitor for Gαi subunits
De Vries L, Fischer T, Tronchère H, Brothers G, Strockbine B, Siderovski D, Farquhar M. Activator of G protein signaling 3 is a guanine dissociation inhibitor for Gαi subunits. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 14364-14369. PMID: 11121039, PMCID: PMC18924, DOI: 10.1073/pnas.97.26.14364.Peer-Reviewed Original ResearchMeSH KeywordsAluminum CompoundsAmino Acid MotifsAmino Acid SequenceAnimalsCell FractionationFluoridesGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding ProteinsGuanineGuanine Nucleotide Dissociation InhibitorsGuanosine DiphosphateHeterotrimeric GTP-Binding ProteinsMolecular Sequence DataRatsTissue DistributionConceptsActivator of G-protein signaling 3Guanine dissociation inhibitorGDP-bound formHeterotrimeric G proteinsGoLoco motifDissociation inhibitorG-proteinHeterotrimeric G protein signalingRate of exchange of GDPTissue-specific alternative splicingSignaling 3Exchange of GDPFamily of proteinsG protein signalingGalpha(o) subunitsAlternative splicingBinding motifSignal transductionGalpha subunitsNorthern blottingPC-12 cellsGTPgammaS binding assaySubunitTryptophan fluorescenceBinding assays
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