2025
Oncologic Outcomes with De-Escalation of Axillary Surgery After Neoadjuvant Chemotherapy for Breast Cancer: Results from > 1500 Patients on the I-SPY2 Clinical Trial
Boughey J, Yu H, Switalla K, Velle L, Lopes A, Wallace A, Lancaster R, Reyna C, Tuttle T, Jaskowiak N, Tchou J, Rao R, Lee M, Naik A, Golshan M, Arciero C, Sauder C, Matsen C, Yau C, Esserman L, Mukhtar R. Oncologic Outcomes with De-Escalation of Axillary Surgery After Neoadjuvant Chemotherapy for Breast Cancer: Results from > 1500 Patients on the I-SPY2 Clinical Trial. Annals Of Surgical Oncology 2025, 32: 3278-3291. PMID: 39946078, DOI: 10.1245/s10434-025-16973-y.Peer-Reviewed Original ResearchEvent-free survivalDe-escalation of axillary surgeryLocoregional recurrenceNeoadjuvant chemotherapyALND groupAxillary surgeryOncological outcomesI-SPY2Breast cancerDe-EscalationRate of axillary recurrenceMedian follow-up timeShort-term follow-upAxillary surgery typeOmission of ALNDResidual nodal diseaseReduce patient morbidityYpN+ diseaseAdjuvant radiationAxillary recurrenceNodal diseaseYpN+ patientsSurgery typePatient morbidityTrial patients
2024
Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidity
2017
Radioprotective agents to prevent cellular damage due to ionizing radiation
Smith T, Kirkpatrick D, Smith S, Smith T, Pearson T, Kailasam A, Herrmann K, Schubert J, Agrawal D. Radioprotective agents to prevent cellular damage due to ionizing radiation. Journal Of Translational Medicine 2017, 15: 232. PMID: 29121966, PMCID: PMC5680756, DOI: 10.1186/s12967-017-1338-x.Peer-Reviewed Original ResearchConceptsRadioprotective agentsIonizing RadiationReduce patient morbidityIonizing Radiation ExposurePatient morbidityLow dosesAntioxidant rich foodsAccurate diagnosisComponents of patient careRadiation exposureImaging modalitiesDecrease free radical damageDiet recommendationsReactive oxygen speciesCell damageFree radical damageRich foodsCellular damageDNA damageLipid membrane damageOxygen speciesRadical damagePrevent cellular damageAgentsMembrane damageA Comprehensive Guide to Perioperative Management and Operative Technique for Robotic Cystectomy with Intracorporeal Urinary Diversion
Tan W, Lamb B, Sridhar A, Briggs T, Kelly J. A Comprehensive Guide to Perioperative Management and Operative Technique for Robotic Cystectomy with Intracorporeal Urinary Diversion. Urologia Journal 2017, 84: 71-78. PMID: 28256704, DOI: 10.5301/uj.5000224.Peer-Reviewed Original ResearchConceptsRobotic-assisted radical cystectomyOpen radical cystectomyConversion to open surgeryReturn to normal functionOncological outcomesRadical cystectomyOpen surgeryUrinary diversionEarly return to normal functionLack of level 1 evidenceShort-term oncological outcomesHigh-volume centresLevel 1 evidenceMinimally invasive approachReduce patient morbidityIntracorporeal urinary diversionEnhanced recovery protocolEarly surgical experienceHigh-volume experienceNormal functionRobotic cystectomyOncologic equivalencePerioperative complicationsPatient selectionInvasive approach
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