2020
DNA aptamer-based non-faradaic impedance biosensor for detecting E. coli
Abdelrasoul GN, Anwar A, MacKay S, Tamura M, Shah MA, Khasa DP, Montgomery RR, Ko AI, Chen J. DNA aptamer-based non-faradaic impedance biosensor for detecting E. coli. Analytica Chimica Acta 2020, 1107: 135-144. PMID: 32200887, DOI: 10.1016/j.aca.2020.02.004.Peer-Reviewed Original ResearchConceptsField-emission scanning electron microscopyImpedance-based biosensorAtomic force microscopySelf-assembled monolayersInterdigitated ElectrodesIDE surfaceSubstrate materialEmission scanning electron microscopyMolecular recognition elementsEnzyme-linked immunosorbent assayConventional detection approachesScanning electron microscopyIDE arrayImpedance biosensorLimit of detectionForce microscopyBiosensorSurface chemistryAptamerPolymerase chain reaction assaysRecognition elementThiol mixturesElectron microscopyEnvironmental monitoringChain reaction assays
2019
MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis
Moro A, Driscoll TP, Boraas LC, Armero W, Kasper DM, Baeyens N, Jouy C, Mallikarjun V, Swift J, Ahn SJ, Lee D, Zhang J, Gu M, Gerstein M, Schwartz M, Nicoli S. MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis. Nature Cell Biology 2019, 21: 348-358. PMID: 30742093, PMCID: PMC6528464, DOI: 10.1038/s41556-019-0272-y.Peer-Reviewed Original ResearchConceptsArgonaute 2MicroRNA-dependent regulationMechanical homeostasisMicroRNA recognition elementsExtracellular matrix proteinsZebrafish finsMicroRNA familiesTarget mRNAsVertebrate tissuesHyper-contractile phenotypesRegulatory pathwaysUntranslated regionRecognition elementMatrix proteinsComprehensive identificationCaM mRNAConnective tissue growth factorExtracellular matrix depositionHomeostasisTissue growth factorMRNAFibroblast cellsMicroRNAsGrowth factorSoft substrates
2006
Molecular Recognition in the Selective Oxygenation of Saturated C-H Bonds by a Dimanganese Catalyst
Das S, Incarvito CD, Crabtree RH, Brudvig GW. Molecular Recognition in the Selective Oxygenation of Saturated C-H Bonds by a Dimanganese Catalyst. Science 2006, 312: 1941-1943. PMID: 16809537, DOI: 10.1126/science.1127899.Peer-Reviewed Original ResearchConceptsHydrogen bondingMolecular recognitionH bondsCarboxylic acid groupsMolecular recognition elementsSynthetic catalystsSaturated CKemp's triacidSelective oxygenationCOOH groupRegioselective functionalizationH activationHigh selectivityAcid groupsRecognition groupReactive centerRecognition elementCatalystTriacidOrient substratesSelectivityBondingBondsControl experimentsSubstrate
2001
ClpA mediates directional translocation of substrate proteins into the ClpP protease
Reid B, Fenton W, Horwich A, Weber-Ban E. ClpA mediates directional translocation of substrate proteins into the ClpP protease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 3768-3772. PMID: 11259663, PMCID: PMC31127, DOI: 10.1073/pnas.071043698.Peer-Reviewed Original ResearchConceptsSubstrate proteinsClpP proteaseUnfolded substrate proteinsATP-dependent unfoldingATP-dependent mannerATP-dependent translocationChaperone ClpAProteolytic chamberFluorescence resonance energy transferDirectional translocationCOOH terminusClpAResonance energy transferProteinTranslocationIntracellular degradationFluorescence anisotropyProteaseRing complexTerminusLarge assembliesDonor fluorophoreRecognition elementRecent studiesHslUV
1996
Structural Basis for the Autoinhibition of Calcium/Calmodulin-Dependent Protein Kinase I
Goldberg J, Nairn A, Kuriyan J. Structural Basis for the Autoinhibition of Calcium/Calmodulin-Dependent Protein Kinase I. Cell 1996, 84: 875-887. PMID: 8601311, DOI: 10.1016/s0092-8674(00)81066-1.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsBinding SitesCalcium-Calmodulin-Dependent Protein Kinase Type 1Calcium-Calmodulin-Dependent Protein KinasesCrystallographyImage Processing, Computer-AssistedMolecular Sequence DataPhosphorylationProtein ConformationProtein KinasesRatsSequence Homology, Amino AcidSubstrate SpecificityConceptsCalmodulin-dependent protein kinase ICalcium/calmodulin-dependent protein kinase IProtein kinase IKinase IRegulatory regionsATP-binding domainTerminal regulatory regionCatalytic domainCatalytic coreSecond helixStructural basisAlpha-helixCalmodulin targetsConformational changesPeptide substratesHelix segmentsCalmodulinHelixSubstantial structural changesRecognition elementInitial interactionInhibitory interactionsDomainAutoinhibitionCrystal structure[26] Synthesis and evaluation of 1,4-benzodiazepine libraries
Bunin B, Plunkett M, Ellman J. [26] Synthesis and evaluation of 1,4-benzodiazepine libraries. Methods In Enzymology 1996, 267: 448-465. PMID: 8743332, DOI: 10.1016/s0076-6879(96)67028-1.Peer-Reviewed Original ResearchConceptsSolid-phase synthesis methodLead compoundsMillions of compoundsClass of moleculesChemical functionalityBenzodiazepine derivativesDrug discovery effortsLarge combinatorial librariesBroad biological activitiesLead identificationKey recognition elementRecognition elementSynthesis methodCombinatorial librariesEnzyme targetsDesirable pharmacokineticsHigh-affinity ligandsSimultaneous synthesisCompoundsBiological activityDiscovery effortsPowerful chemicalBiological methodsSynthesisDerivatives
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply