2024
Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample
Cinciripini P, Wetter D, Wang J, Yu R, Kypriotakis G, Kumar T, Robinson J, Cui Y, Green C, Bergen A, Kosten T, Scherer S, Shete S. Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample. Scientific Reports 2024, 14: 6385. PMID: 38493193, PMCID: PMC10944542, DOI: 10.1038/s41598-024-56750-7.Peer-Reviewed Original ResearchConceptsIdentification of novel lociSequencing of candidate genesRare variant associationsMapped to genesReceptor Signaling PathwayNovel lociGenes associated with regulationVariant associationsCandidate genesProtective lociDeep sequencingRegulation of bodyweightGenetic studiesCanonical pathwaysSignaling pathwayRare variantsGenetic profileTarget of pharmacotherapyTumor suppressionAssociated with cancerGenesPublic health tollRandomized Controlled TrialsSubstance use disordersEthnically diverse sample
2023
Blood transcriptional correlates of BCG-induced protection against tuberculosis in rhesus macaques
Liu Y, Darrah P, Zeppa J, Kamath M, Laboune F, Douek D, Maiello P, Roederer M, Flynn J, Seder R, Khatri P. Blood transcriptional correlates of BCG-induced protection against tuberculosis in rhesus macaques. Cell Reports Medicine 2023, 4: 101096. PMID: 37390827, PMCID: PMC10394165, DOI: 10.1016/j.xcrm.2023.101096.Peer-Reviewed Original ResearchConceptsArea under the receiver operating characteristic curveDay 2 post-vaccinationCorrelates of vaccine-induced protectionRobust correlates of protectionLow-dose recipientsHigh-dose i.Rhesus macaquesBCG-induced protectionCorrelates of protectionResponse to i.Receiver operating characteristic curveType 1 interferonVaccine-induced protectionBCG recipientsCohort of macaquesCD4 TPeripheral bloodWeek 8Receptor Signaling PathwayTuberculosisCharacteristic curveBCGBlood transcriptomeMycobacterium tuberculosisBloodBiomarker analysis from a phase I/I1b study of regorafenib and nivolumab (rego/nivo) in microsatellite stable (MSS) colorectal cancer (CRC).
Yu J, Kim Y, Mehta R, Miao R, Strosberg J, Imanirad I, Kim D, Kim R. Biomarker analysis from a phase I/I1b study of regorafenib and nivolumab (rego/nivo) in microsatellite stable (MSS) colorectal cancer (CRC). Journal Of Clinical Oncology 2023, 41: 188-188. DOI: 10.1200/jco.2023.41.4_suppl.188.Peer-Reviewed Original ResearchPathway enrichment analysisReceptor Signaling PathwayEnrichment analysisProgressive diseaseB cell activationGene OntologyCell-substrate junction assemblySignaling pathwayGO pathway enrichment analysisPositive regulation of B cell activationDownregulated pathwaysKyoto Encyclopedia of GenesSerine-type endopeptidase activityPredictive biomarkersMSS-CRCKEGG pathway enrichment analysisRegulation of B cell activationECM-receptor interactionTumor samplesEncyclopedia of GenesColorectal cancerGenomes (KEGGExtracellular matrixPre-treatment tumor samplesGene Set Enrichment Analysis
2022
Integrated Approaches to Identify miRNA Biomarkers Associated with Cognitive Dysfunction in Multiple Sclerosis Using Text Mining, Gene Expression, Pathways, and GWAS
Prabahar A, Raja K. Integrated Approaches to Identify miRNA Biomarkers Associated with Cognitive Dysfunction in Multiple Sclerosis Using Text Mining, Gene Expression, Pathways, and GWAS. Diagnostics 2022, 12: 1914. PMID: 36010264, PMCID: PMC9406323, DOI: 10.3390/diagnostics12081914.Peer-Reviewed Original ResearchGenome-wide association studiesGenome-wide association study signalsGenome-wide association study catalogECM-receptor signaling pathwayPathway analysisSignaling pathwaySusceptibility genetic lociSusceptibility genetic variantsReceptor Signaling PathwayAssociation signalsGenetic lociGenomic etiologyAssociation studiesGene regulationTranscriptomic studiesGenetic variantsPI3K/Akt Signaling PathwayGene expressionComprehensive repositoryGenetic riskPathwayHsa-miR-148b-3pGenesExperimental associationsAssociation networks
2007
Functional Expression of Key Components of the Olfactory Receptor Signaling Pathway in the Distal Nephron
Pluznick J, Zhang X, Zou D, Yan Q, Wells E, Wang T, Firestein S, Caplan M. Functional Expression of Key Components of the Olfactory Receptor Signaling Pathway in the Distal Nephron. The FASEB Journal 2007, 21: a500-a500. DOI: 10.1096/fasebj.21.5.a500.Peer-Reviewed Original ResearchGlomerular filtration rateMouse kidneyRenal function studiesMacula densa cellsWild-type littermatesNormal mouse kidneyOlfactory G-proteinOlfactory receptorsReceptor Signaling PathwayRenal functionFiltration rateDistal tubulesDistal nephronKidneyWestern blotTubule segmentsRT-PCRAdenylyl cyclaseMiceNon-olfactory tissuesPotential roleG proteinsSignaling pathwaysFunction studiesMD cells
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