2013
The NHR-8 Nuclear Receptor Regulates Cholesterol and Bile Acid Homeostasis in C. elegans
Magner DB, Wollam J, Shen Y, Hoppe C, Li D, Latza C, Rottiers V, Hutter H, Antebi A. The NHR-8 Nuclear Receptor Regulates Cholesterol and Bile Acid Homeostasis in C. elegans. Cell Metabolism 2013, 18: 212-224. PMID: 23931753, PMCID: PMC3909615, DOI: 10.1016/j.cmet.2013.07.007.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApolipoproteinsBile Acids and SaltsBiological TransportCaenorhabditis elegansCaenorhabditis elegans ProteinsCholestenesCholesterolFatty AcidsFertilityForkhead Transcription FactorsGene Expression RegulationHomeostasisLipid MetabolismLongevityMolecular Sequence DataOxygenasesReceptors, Cytoplasmic and NuclearSequence AlignmentSignal TransductionTranscription FactorsConceptsNuclear receptorsDAF-16/FOXOFatty acid desaturationCholesterol balanceDauer stageNHR-8Dafachronic acidTranscriptional regulatorsDevelopmental arrestNuclear receptor controlLiver XAcid homeostasisAcid metabolismUnregulated growthVitamin D receptorCholesterol availabilityReceptor controlEndocrine networkHomeostasisLife spanReproductionMetabolismBile acid homeostasisApolipoprotein productionImportant insights
2004
Toll-like receptor control of the adaptive immune responses
Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nature Immunology 2004, 5: 987-995. PMID: 15454922, DOI: 10.1038/ni1112.Peer-Reviewed Original ResearchConceptsToll-like receptorsAdaptive immune responsesImmune responseMechanisms of TLRToll-like receptor controlHost defense responsesDendritic cell functionDendritic cell populationsMicrobial infectionsInnate immune systemDistinct anatomical locationsInflammatory reactionAdaptive immunityImmune systemAnatomical locationReceptor controlCell functionCell populationsMultiple mechanismsInfectionRecent studiesResponseInitiationSystemic defenseImportant clues
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