2017
Single-scan rest/stress imaging: validation in a porcine model with 18F-Flurpiridaz
Guehl N, Normandin M, Wooten D, Rozen G, Sitek A, Ruskin J, Shoup T, Ptaszek L, El Fakhri G, Alpert N. Single-scan rest/stress imaging: validation in a porcine model with 18F-Flurpiridaz. European Journal Of Nuclear Medicine And Molecular Imaging 2017, 44: 1538-1546. PMID: 28365789, DOI: 10.1007/s00259-017-3684-6.Peer-Reviewed Original ResearchConceptsMyocardial blood flowMicrosphere flow measurementsBlood flowStress myocardial blood flowSingle-scan protocolClinical applicationShort-axis viewMyocardial blood flow measurementsPET dataBlood flow changesIntroduction of adenosineHalf-life of 18FAdenosine infusionRadiotracer injectionAxis viewMyocardial segmentsHealthy pigsClinical translationPET acquisitionTwo-injectionPig modelIschemic areaPorcine modelHalf-lifeAdenosine
2010
Recent Progress on SPECT Imaging with Near-field Coded Aperture Collimation: A Small Animal Study
Mu Z, Dobrucki W, Hu X, Liu Y. Recent Progress on SPECT Imaging with Near-field Coded Aperture Collimation: A Small Animal Study. 2010, 3450-3453. DOI: 10.1109/nssmic.2010.5874447.Peer-Reviewed Original ResearchAnimal studiesOpen chest surgeryMyocardial perfusion defectsLeft ventricular myocardiumThree-dimensional single photon emissionSingle photon emissionVivo rat heartsPermanent myocardial infarctionCoronary arteryMyocardial infarctionSmall animal studiesPerfusion defectsJugular veinSurgical proceduresRadiotracer injectionVentricular myocardiumRat heartRatsLVAnimal imaging systemAnterior regionSmall animal imaging systemSPECTPhoton emissionSPECT technology
1995
Myocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group.
Zaret B, Rigo P, Wackers F, Hendel R, Braat S, Iskandrian A, Sridhara B, Jain D, Itti R, Serafini A, Goris M, Lahiri A. Myocardial perfusion imaging with 99mTc tetrofosmin. Comparison to 201Tl imaging and coronary angiography in a phase III multicenter trial. Tetrofosmin International Trial Study Group. Circulation 1995, 91: 313-9. PMID: 7805233, DOI: 10.1161/01.cir.91.2.313.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseaseTetrofosmin imagingCoronary angiographyMyocardial perfusionTetrofosmin imagesHealthy subjectsPhase III multicenter trialConventional myocardial perfusionLower likelihoodCentral core laboratoryMyocardial perfusion abnormalitiesNew 99mTcPeak heart rateNegative predictive accuracyMyocardial perfusion imagingNew myocardial imaging agentPlanar 201TlMulticenter trialNormalcy rateCoronary angiogramDouble productPerfusion abnormalitiesMyocardial imaging agentRadiotracer injection
1994
Technetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia.
Sinusas AJ, Shi Q, Saltzberg MT, Vitols P, Jain D, Wackers FJ, Zaret BL. Technetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia. Journal Of Nuclear Medicine 1994, 35: 664-71. PMID: 8151391.Peer-Reviewed Original ResearchConceptsTechnetium-99mCanine modelPerfusion tracerMicrosphere flowCoronary artery occlusionInitial myocardial uptakeIntact canine modelOpen-chest dogsMyocardial perfusion imagingMyocardial blood flowDynamic planar imagingArtery occlusionPharmacological vasodilatationPharmacological stressMyocardial perfusion tracersMyocardial uptakeRadiotracer injectionBlood flowMyocardial perfusionPerfusion imagingArterial samplingMyocardial flowBackground activity ratioTetrofosminIschemia
1993
Biokinetics of technetium-99m-tetrofosmin: myocardial perfusion imaging agent: implications for a one-day imaging protocol.
Jain D, Wackers FJ, Mattera J, McMahon M, Sinusas AJ, Zaret BL. Biokinetics of technetium-99m-tetrofosmin: myocardial perfusion imaging agent: implications for a one-day imaging protocol. Journal Of Nuclear Medicine 1993, 34: 1254-9. PMID: 8326381.Peer-Reviewed Original ResearchConceptsOrgan ratiosGastrointestinal tractRest imagesImaging protocolSymptom-limited treadmill exerciseDecay-corrected countsLeft anterior oblique viewStress imagesAnterior oblique viewPortion of liverOptimal imaging protocolMyocardial perfusion imaging agentPeak exerciseTreadmill exerciseClinical trialsTechnetium-99mRadiotracer injectionMyocardial perfusionTetrofosmin imagesGallbladderPhase IEntire heartLiverTractOblique view
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