2007
Novel Approach to Performing Metabolite Identification in Drug Metabolism
Nassar A, Lee D. Novel Approach to Performing Metabolite Identification in Drug Metabolism. Journal Of Chromatographic Science 2007, 45: 113-119. PMID: 17462124, DOI: 10.1093/chromsci/45.3.113.Peer-Reviewed Original ResearchConceptsMetabolite identificationHuman liver microsomal incubationsMetabolite identification studiesDrug discoveryMS fragmentation patternsLiver microsomal incubationsLimit of detectionSite of metabolismDynamic-flow methodMass spectrometric analysisMultistage fragmentationMass spectrometerFragmentation patternsMicrosomal incubationsOnline separationChromatographic peaksMass spectrometryMinor metabolitesSpectrometric analysisFraction collectionO-dealkylationRadioactivity detectorMetabolite of dextromethorphanRadioactivity detectionColumn pressure
1999
Two Pharmacologically Distinct Components of Nicotinic Receptor-Mediated Rubidium Efflux in Mouse Brain Require the β2 Subunit 1
Marks MJ, Whiteaker P, Calcaterra J, Stitzel JA, Bullock AE, Grady SR, Picciotto MR, Changeux JP, Collins AC. Two Pharmacologically Distinct Components of Nicotinic Receptor-Mediated Rubidium Efflux in Mouse Brain Require the β2 Subunit 1. Journal Of Pharmacology And Experimental Therapeutics 1999, 289: 1090-1103. PMID: 10215692, DOI: 10.1016/s0022-3565(24)38240-0.Peer-Reviewed Original ResearchConceptsBeta2 subunitBeta2 null mutant miceConcentration-effect curvesMouse brain synaptosomesAlpha4beta2 receptorsBrain synaptosomesNicotinic agonistsMouse brainRubidium effluxMutant miceLine radioactivity detectionDHbetaEAgonistsEffluxBrainStimulationRadioactivity detectionPotencyHexamethoniumErythroidineResponseAcetylcholineMethyllycaconitineAntagonistBungarotoxin
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