2024
In vitro efficacy of next-generation dihydrotriazines and biguanides against babesiosis and malaria parasites
Vydyam P, Chand M, Gihaz S, Renard I, Heffernan G, Jacobus L, Jacobus D, Saionz K, Shah R, Shieh H, Terpinski J, Zhao W, Cornillot E, Mamoun C. In vitro efficacy of next-generation dihydrotriazines and biguanides against babesiosis and malaria parasites. Antimicrobial Agents And Chemotherapy 2024, 68: e00423-24. PMID: 39136469, PMCID: PMC11373198, DOI: 10.1128/aac.00423-24.Peer-Reviewed Original ResearchTherapeutic indexPlasmodium falciparum</i>Effective therapeutic strategyCausative agent of babesiosisIn vitro efficacyAntiparasitic drugsProtozoan parasitesMalaria parasitesIntraerythrocytic protozoan parasiteTherapeutic strategiesFolate pathwayBroad-spectrum antiparasitic drugStrain HB3Babesia divergensMalariaBabesia duncaniAnimal healthAntifolatesDrugWidespread resistanceCausative agentBiguanideBabesiaBabesiosisBiosynthesis of purines
2010
Functional Studies of Plasmodium falciparum Dipeptidyl Aminopeptidase I Using Small Molecule Inhibitors and Active Site Probes
Deu E, Leyva MJ, Albrow VE, Rice MJ, Ellman JA, Bogyo M. Functional Studies of Plasmodium falciparum Dipeptidyl Aminopeptidase I Using Small Molecule Inhibitors and Active Site Probes. Cell Chemical Biology 2010, 17: 808-819. PMID: 20797610, PMCID: PMC2929396, DOI: 10.1016/j.chembiol.2010.06.007.Peer-Reviewed Original ResearchConceptsDipeptidyl aminopeptidasesActivity-based probesSmall molecules resultsNew targetsSmall molecule inhibitorsDipeptidyl aminopeptidase IActive site probesValuable new targetsAminopeptidase IAntimalarial targetImmature trophozoitesMolecule inhibitorsFunctional studiesCovalent inhibitorsParasite growthMalaria parasitesHemoglobin degradationSite probesLow nanomolar concentrationsSpecific inhibitionPlasmodium falciparumNanomolar concentrationsWidespread resistanceInhibitionTarget
1992
MEDICAL CONSIDERATIONS FOR THE PREGNANT TRAVELER
Bia F. MEDICAL CONSIDERATIONS FOR THE PREGNANT TRAVELER. Infectious Disease Clinics Of North America 1992, 6: 371-388. PMID: 1624782, DOI: 10.1016/s0891-5520(20)30447-5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPregnant travelersHigh-altitude trekkingRisk of diseaseVaccine complicationsMalaria prophylaxisVigorous exerciseClinical informationUnnecessary exposureMedical considerationsPlasmodium speciesAntiparasitic agentsCommercial air travelWidespread resistanceRiskProphylaxisComplicationsPregnancyImmunizationFetusesDiseaseCare
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