2023
High-Dose Targeted Radiation with 131I-Apamistamab Prior to HCT Demonstrated a Dose-Response for Durable Complete Remission in Patients with R/R AML
Litzow M, Chen G, Gyurkocza B, Nath R, Seropian S, Choe H, Abboud C, Koshy N, Tomlinson B, Abhyankar S, Foran J, Abedin S, Al-Kadhimi Z, Kebriaei P, Sabloff M, Orozco J, Jamieson K, Magalhaes-Silverman M, Van Besien K, Schuster M, Law A, Mayer S, Lazarus H, Leung E, Chen M, Natwa M, Spross J, Li K, Nagl N, Haeuber E, Vusirikala M, Nahar A, Sandmaier B, Pagel J, Giralt S, Desai A, Wahl R, Pandit-Taskar N, Brodin P, Stiff P. High-Dose Targeted Radiation with 131I-Apamistamab Prior to HCT Demonstrated a Dose-Response for Durable Complete Remission in Patients with R/R AML. Blood 2023, 142: 3529. DOI: 10.1182/blood-2023-189040.Peer-Reviewed Original ResearchDurable complete remissionConventional careLiver dosePrimary endpointBone marrowR AMLComplete remissionLiver ratioHigh doseLeukemic cellsRadiation doseAllogeneic hematopoietic cell transplantRadiation dose-response relationshipHematopoietic cell transplantMost older patientsPhase 3 studyTotal body irradiationFavorable biodistributionRadiation dose toleranceYears of ageDose toleranceDose-response relationshipDiseased bone marrowMedian doseRefractory AMLRisk of Subsequent Neoplasms in Childhood Cancer Survivors After Radiation Therapy: A PENTEC Comprehensive Review
Casey D, Vogelius I, Brodin N, Roberts K, Avanzo M, Moni J, Owens C, Ronckers C, Constine L, Bentzen S, Olch A. Risk of Subsequent Neoplasms in Childhood Cancer Survivors After Radiation Therapy: A PENTEC Comprehensive Review. International Journal Of Radiation Oncology • Biology • Physics 2023, 119: 640-654. PMID: 37777927, DOI: 10.1016/j.ijrobp.2023.07.025.Peer-Reviewed Original ResearchChildhood cancer survivorsCancer survivorsRadiation therapySubsequent meningiomaLung cancerCNS neoplasmsSubsequent neoplasmsSubsequent sarcomaRT dosePrimary diagnosisHigh riskPediatric Normal Tissue EffectsRadiation dose-response relationshipSubsequent lung cancerPrior radiation therapyTreatment-related factorsExcess absolute riskPrimary cancer diagnosisERR/GyNormal tissue effectsSpecific chemotherapeutic agentsDose-response relationshipHigh-dose volumeSignificant contributory roleERR/
2022
Risk of Subsequent Central Nervous System Neoplasms in Childhood Cancer Survivors after Radiation Therapy: Results from the Pediatric Normal Tissue Effects in the Clinic (PENTEC) Collaboration
Casey D, Brodin P, Roberts K, Vogelius I, Avanzo M, Moni J, Owens C, Ronckers C, Constine L, Bentzen S, Olch A. Risk of Subsequent Central Nervous System Neoplasms in Childhood Cancer Survivors after Radiation Therapy: Results from the Pediatric Normal Tissue Effects in the Clinic (PENTEC) Collaboration. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: s122-s123. DOI: 10.1016/j.ijrobp.2022.07.568.Peer-Reviewed Original ResearchSubsequent malignant tumorChildhood cancer survivorsMalignant CNS tumorsSubsequent meningiomaExcess odds ratioMalignant tumorsRadiation therapyCancer survivorsRT doseCNS tumorsOdds ratioHigh riskPediatric Normal Tissue EffectsPrior cranial radiation therapyCentral nervous system neoplasmsRadiation dose-response relationshipMalignant CNS tumorPrimary cancer diagnosisCranial radiation therapyNervous system neoplasmsIndependent patient cohortsDifferent dose intervalsNormal tissue effectsDose-response relationshipMATERIAL/METHODS
2020
The Impact of Radiation Energy on Dose Homogeneity and Organ Dose in the Gttingen Minipig Total-Body Irradiation Model
Poirier Y, Becker S, Decesaris C, Culberson W, Draeger E, Gerry AJ, Johnstone CD, Gibbs A, Vujaskovic Z, Jackson IL. The Impact of Radiation Energy on Dose Homogeneity and Organ Dose in the Gttingen Minipig Total-Body Irradiation Model. Radiation Research 2020, 194: 544-556. PMID: 33045066, DOI: 10.1667/rade-20-00135.1.Peer-Reviewed Original ResearchMeSH KeywordsAbdomenAbsorption, RadiationAnimalsBody SizeBody WeightCobalt RadioisotopesDose-Response Relationship, RadiationGamma RaysMaleModels, AnimalOrgan SpecificityParticle AcceleratorsPelvisPhotonsProne PositionRadiation DosageRadiation ToleranceRadioisotope TeletherapyRadiotherapy Planning, Computer-AssistedRadiotherapy, High-EnergyShoulderSwineSwine, MiniatureTomography, X-Ray ComputedWhole-Body IrradiationConceptsTotal body irradiationDose-volume histogramsGöttingen minipigsThoracic organsMedical countermeasuresRadiation dose-response relationshipDose-response relationshipNormal tissue damageDose distributionExperienced radiation oncologistsAdditional confounding factorsTBI modelPelvic organsHigh doseIndividual organsAnimal modelsAverage doseConfounding factorsRadiation oncologistsTissue damageLess doseOrgan doseAverage dosesDose homogeneityDoseUse of CT simulation and 3-D radiation therapy treatment planning system to develop and validate a total-body irradiation technique for the New Zealand White rabbit
Poirier Y, Prado C, Prado K, Draeger E, Jackson IL, Vujaskovic Z. Use of CT simulation and 3-D radiation therapy treatment planning system to develop and validate a total-body irradiation technique for the New Zealand White rabbit. International Journal Of Radiation Biology 2020, 97: s10-s18. PMID: 32924716, DOI: 10.1080/09553002.2019.1665215.Peer-Reviewed Original ResearchConceptsNew Zealand white rabbitsAcute radiation syndromeDose-response relationshipZealand white rabbitsTBI techniquePrescribed doseAverage doseWhite rabbitsTotal body irradiation (TBI) exposureRadiation dose-response relationshipTotal body irradiation techniqueMedical countermeasure efficacyMonitor unitsLeft decubitus positionTreatment planning systemMaximal doseRadiation syndromeIndividual organ dosesAnimal modelsRadiotherapy techniquesTherapy treatment planning systemCountermeasure efficacyExperienced dosimetristDecreased attenuationDose homogeneity
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