2012
Lupus autoimmunity altered by cellular methylation metabolism
Yang ML, Gee AJ, Gee RJ, Zurita-Lopez CI, Khare S, Clarke SG, Mamula MJ. Lupus autoimmunity altered by cellular methylation metabolism. Autoimmunity 2012, 46: 21-31. PMID: 23039363, PMCID: PMC3543504, DOI: 10.3109/08916934.2012.732133.Peer-Reviewed Original ResearchConceptsS-adenosylmethionineTCR-mediated T cell proliferationImmune responseCell proliferationLupus-prone MRL/lpr miceT-cell activation markersMRL/lpr miceTh1/Th2 cytokinesB cell immune responsesMajor methyl donorDimethylarginine residuesT cell immunityCell activation markersT cell autoreactivityT cell responsesMethylated proteinsCell immune responsesTarget of autoimmunityT cell proliferationIncubation of cellsB cell proliferationDose-dependent mannerSAM metabolismLupus autoimmunityMethylation status
2004
Resistance to Development of Collagen-Induced Arthritis in C57BL/6 Mice Is Due to a Defect in Secondary, but Not in Primary, Immune Response
Pan M, Kang I, Craft J, Yin Z. Resistance to Development of Collagen-Induced Arthritis in C57BL/6 Mice Is Due to a Defect in Secondary, but Not in Primary, Immune Response. Journal Of Clinical Immunology 2004, 24: 481-491. PMID: 15359107, DOI: 10.1023/b:joci.0000040919.16739.44.Peer-Reviewed Original ResearchConceptsCollagen-induced arthritisB6 miceImmune responseSimilar T cell proliferationBovine type II collagenB cell immune responsesH-2b backgroundAnti-CII antibodiesHuman rheumatoid arthritisT cell responsesCell immune responsesSecondary immune responseT cell proliferationCII AbsCytokine responsesRheumatoid arthritisInitial immunizationC57BL/6 miceRodent modelsArthritisType II collagenDay 14Cell responsesDay 12Mice
2003
CD69 downregulates autoimmune reactivity through active transforming growth factor-β production in collagen-induced arthritis
Sancho D, Gómez M, Viedma F, Esplugues E, Gordón-Alonso M, García-López MA, de la Fuente H, Martínez-A C, Lauzurica P, Sánchez-Madrid F. CD69 downregulates autoimmune reactivity through active transforming growth factor-β production in collagen-induced arthritis. Journal Of Clinical Investigation 2003, 112: 872-882. PMID: 12975472, PMCID: PMC193672, DOI: 10.1172/jci19112.Peer-Reviewed Original ResearchConceptsCollagen-induced arthritisCD69-/- miceAutoimmune reactivitySeverity of CIAProinflammatory cytokine mRNA levelsB cell immune responsesProinflammatory cytokines IL-1betaCD69-deficient miceRole of CD69Cell immune responsesCytokine mRNA levelsCytokines IL-1betaActivation of leukocytesTGF-beta1 productionNegative cell linesSplenocyte subsetsProinflammatory mediatorsBeta antibodyIL-1betaInflammatory fociLocal injectionSynovial leukocytesImmune responseCIA severityInflammatory sites
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