2012
Lupus autoimmunity altered by cellular methylation metabolism
Yang ML, Gee AJ, Gee RJ, Zurita-Lopez CI, Khare S, Clarke SG, Mamula MJ. Lupus autoimmunity altered by cellular methylation metabolism. Autoimmunity 2012, 46: 21-31. PMID: 23039363, PMCID: PMC3543504, DOI: 10.3109/08916934.2012.732133.Peer-Reviewed Original ResearchConceptsS-adenosylmethionineTCR-mediated T cell proliferationImmune responseCell proliferationLupus-prone MRL/lpr miceT-cell activation markersMRL/lpr miceTh1/Th2 cytokinesB cell immune responsesMajor methyl donorDimethylarginine residuesT cell immunityCell activation markersT cell autoreactivityT cell responsesMethylated proteinsCell immune responsesTarget of autoimmunityT cell proliferationIncubation of cellsB cell proliferationDose-dependent mannerSAM metabolismLupus autoimmunityMethylation status
2000
PRMT1 Is the Predominant Type I Protein Arginine Methyltransferase in Mammalian Cells*
Tang J, Frankel A, Cook R, Kim S, Paik W, Williams K, Clarke S, Herschman H. PRMT1 Is the Predominant Type I Protein Arginine Methyltransferase in Mammalian Cells*. Journal Of Biological Chemistry 2000, 275: 7723-7730. PMID: 10713084, DOI: 10.1074/jbc.275.11.7723.Peer-Reviewed Original ResearchConceptsProtein arginine methyltransferase activityArginine methyltransferase activityMurine tissue extractsMammalian cellsRat1 cellsMethyltransferase activityType I protein arginine methyltransferasesType I protein arginine methyltransferaseHeterogeneous nuclear ribonucleoprotein A1Protein arginine methyltransferasesProtein arginine methyltransferaseFDH activityHigh molecular weight complexesDomain fusion proteinMolecular weight complexesMethyl donor substrateDimethylarginine residuesArginine methyltransferasesArginine methyltransferaseEucaryotic proteinsPRMT1 activityDehydrogenase proteinFusion proteinEnzyme activity presentWeight complexes
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