Improved Intratumoral Oxygenation Through Vascular Normalization Increases Glioma Sensitivity to Ionizing Radiation
McGee M, Hamner J, Williams R, Rosati S, Sims T, Ng C, Gaber M, Calabrese C, Wu J, Nathwani A, Duntsch C, Merchant T, Davidoff A. Improved Intratumoral Oxygenation Through Vascular Normalization Increases Glioma Sensitivity to Ionizing Radiation. International Journal Of Radiation Oncology • Biology • Physics 2010, 76: 1537-1545. PMID: 20338480, PMCID: PMC2846307, DOI: 10.1016/j.ijrobp.2009.12.010.Peer-Reviewed Original ResearchConceptsTumor vasculatureIntratumoral oxygenationIFN-betaTumor oxygenationEfficacy of ionizing radiationAdministration of IFN-betaEndothelial cell stainingDysfunctional tumor vasculatureCell stainingQuantitative bioluminescence imagingIonizing RadiationAreas of necrosisCranial irradiationAntiglioma efficacyVascular normalizationU87 xenograftsHypoxyprobe stainingBevacizumabImmunohistochemical stainingTumor growthInterferon-betaVascular phenotypePharmacological manipulationTumorBioluminescence imaging
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