2025
Alternative Splicing Alterations in Patients With Amyotrophic Lateral Sclerosis: Link to the Disruption of TAR DNA‐Binding Protein 43 kDa Functions
Miwa T, Takeuchi E, Ogawa K, Abdelhamid R, Morita J, Hiraki Y, Yasumizu Y, Nakamura Y, Ohkura N, Saito Y, Murayama S, Nagai Y, Mochizuki H, Nagano S. Alternative Splicing Alterations in Patients With Amyotrophic Lateral Sclerosis: Link to the Disruption of TAR DNA‐Binding Protein 43 kDa Functions. Neurology And Clinical Neuroscience 2025, 13: 187-194. DOI: 10.1111/ncn3.12880.Peer-Reviewed Original ResearchAlternative splicing alterationsAlternative splicingTDP-43Splicing changesSplicing alterationsAmyotrophic lateral sclerosis pathologyAmyotrophic lateral sclerosisDNA-binding proteinsDysregulation of alternative splicingTAR DNA-binding proteinAberrant alternative splicingTAR DNA-binding protein 43 kDaSH-SY5Y cellsRNA metabolismDNA-binding protein 43 kDaNovel genesSplicing patternsNeurons of patientsRNA sequencingSplicingLateral sclerosisMotor neuronsTreatment of amyotrophic lateral sclerosisPolymerase chain reaction analysisMotor neurons of patients
2006
Correction of humoral derangements from mutant superoxide dismutase 1 spinal cord
Kim Y, Martinez T, Deshpande D, Drummond J, Provost‐Javier K, Williams A, McGurk J, Maragakis N, Song H, Ming G, Kerr D. Correction of humoral derangements from mutant superoxide dismutase 1 spinal cord. Annals Of Neurology 2006, 60: 716-728. PMID: 17192933, DOI: 10.1002/ana.21034.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisAnimalsAntibodiesCell Line, TransformedCell SurvivalCoculture TechniquesCulture Media, ConditionedDisease Models, AnimalFemaleFree Radical ScavengersHumansInterleukinsMaleMiceMice, TransgenicMotor NeuronsNerve RegenerationNitric OxideOrgan Culture TechniquesSpinal CordSuperoxide DismutaseTreatment OutcomeVascular Endothelial Growth Factor AConceptsStem cell-derived motor neuronsVascular endothelial growth factorEmbryonic stem cell-derived motor neuronsEndothelial growth factorMotor neuronsNeutralizing antibodies to IL-1betaIL-6Levels of vascular endothelial growth factorOrganotypic slicesOrganotypic culturesAntibodies to IL-1betaGrowth factorAxon lengthToxic to motor neuronsAmyotrophic lateral sclerosisTreatment of amyotrophic lateral sclerosisCocultured motor neuronsPresence of reactive oxygen species scavengersCell survivalInterleukin (IL)-1betaSpinal cord organotypic culturesWild-typeOrganotypic slice culturesSecrete high levelsMotor neuron injury
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