Deficiency of Superoxide Dismutase Impairs Protein C Activation and Enhances Susceptibility to Experimental Thrombosis
Dayal S, Gu S, Hutchins R, Wilson K, Wang Y, Fu X, Lentz S. Deficiency of Superoxide Dismutase Impairs Protein C Activation and Enhances Susceptibility to Experimental Thrombosis. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35: 1798-1804. PMID: 26069236, PMCID: PMC4514539, DOI: 10.1161/atvbaha.115.305963.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarotid Artery InjuriesCarotid Artery, CommonCatalaseDisease Models, AnimalEnzyme ActivationHumansMice, 129 StrainMice, TransgenicOxidation-ReductionOxidative StressProtein CSuperoxide DismutaseSuperoxide Dismutase-1SuperoxidesThrombomodulinThrombosisVena Cava, InferiorVenous ThrombosisConceptsSod1(-/-) miceSuperoxide dismutase-1Activation of protein CProtein C activationProtein CInferior vena cava ligationLevels of protein CEndothelial protein C receptorVena cava ligationC activityImpaired protein C activationReactive oxygen speciesGeneration of activated protein CProtein C receptorExpression of thrombomodulinCarotid artery thrombosisThrombosis in vivoIn vitro studiesSod1(-/-Thrombin in vivoLevels of reactive oxygen speciesElevated levels of reactive oxygen speciesVenous thrombosisProthrombotic effectsMurine model
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