2015
Deficiency of Superoxide Dismutase Impairs Protein C Activation and Enhances Susceptibility to Experimental Thrombosis
Dayal S, Gu S, Hutchins R, Wilson K, Wang Y, Fu X, Lentz S. Deficiency of Superoxide Dismutase Impairs Protein C Activation and Enhances Susceptibility to Experimental Thrombosis. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35: 1798-1804. PMID: 26069236, PMCID: PMC4514539, DOI: 10.1161/atvbaha.115.305963.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarotid Artery InjuriesCarotid Artery, CommonCatalaseDisease Models, AnimalEnzyme ActivationHumansMice, 129 StrainMice, TransgenicOxidation-ReductionOxidative StressProtein CSuperoxide DismutaseSuperoxide Dismutase-1SuperoxidesThrombomodulinThrombosisVena Cava, InferiorVenous ThrombosisConceptsSod1(-/-) miceSuperoxide dismutase-1Activation of protein CProtein C activationProtein CInferior vena cava ligationLevels of protein CEndothelial protein C receptorVena cava ligationC activityImpaired protein C activationReactive oxygen speciesGeneration of activated protein CProtein C receptorExpression of thrombomodulinCarotid artery thrombosisThrombosis in vivoIn vitro studiesSod1(-/-Thrombin in vivoLevels of reactive oxygen speciesElevated levels of reactive oxygen speciesVenous thrombosisProthrombotic effectsMurine model
1996
Monoclonal antibody against tissue factor shortens tissue plasminogen activator lysis time and prevents reocclusion in a rabbit model of carotid artery thrombosis.
Ragni M, Cirillo P, Pascucci I, Scognamiglio A, D’Andrea D, Eramo N, Ezekowitz M, Pawashe A, Chiariello M, Golino P. Monoclonal antibody against tissue factor shortens tissue plasminogen activator lysis time and prevents reocclusion in a rabbit model of carotid artery thrombosis. Circulation 1996, 93: 1913-8. PMID: 8635271, DOI: 10.1161/01.cir.93.10.1913.Peer-Reviewed Original ResearchConceptsTissue-type plasminogen activatorCarotid artery thrombosisLysis timeArtery thrombosisMonoclonal antibodiesControl rabbitsThrombus formationRabbit modelEx vivo platelet aggregationAP-1Vivo platelet aggregationDoppler flow probesIntravascular thrombus formationExtrinsic coagulation pathwayPrevents reocclusionReocclusion rateAdjunctive therapyEndothelial injuryExternal constrictorProthrombin timeIntravascular thrombosisCarotid arteryTF exposureSystemic effectsFlow probe
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