2007
Peptide-Nanoparticle Hybrid SERS Probes for Optical Detection of Protease Activity
Liu GL, Rosa-Bauza YT, Salisbury CM, Craik C, Ellman JA, Chen FF, Lee LP. Peptide-Nanoparticle Hybrid SERS Probes for Optical Detection of Protease Activity. Journal Of Nanoscience And Nanotechnology 2007, 7: 2323-2330. PMID: 17663247, DOI: 10.1166/jnn.2007.444.Peer-Reviewed Original ResearchMeSH KeywordsCrystallizationEnzyme ActivationHumansMacromolecular SubstancesMaleMaterials TestingMolecular ConformationMolecular Probe TechniquesNanostructuresNanotechnologyOptics and PhotonicsParticle SizePeptide HydrolasesPeptidesProstate-Specific AntigenSensitivity and SpecificitySpectrum Analysis, RamanSurface PropertiesConceptsEarly-stage cancer screeningBackground Raman signalsHigh reaction specificityTAG moleculesIndividual nanoparticlesRaman spectral signalsSERS probeSerine protease presentProstate cancer markerMicrofluidic deviceOptical detectionRaman signalOptical probeSitu detectionPSA moleculesCancer markersReaction volumeReaction specificityMoleculesPeptide cleavageProstate-specific antigenRadioactive probesNanoparticlesNanoprobeConcept study
2006
Peptide-Nanoparticle Hybrid SERS Probe for Dynamic Detection of Active Cancer Biomarker Enzymes
Liu GL, Chen FF, Ellman JA, Lee LP. Peptide-Nanoparticle Hybrid SERS Probe for Dynamic Detection of Active Cancer Biomarker Enzymes. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2006, 2006: 795-798. PMID: 17946000, DOI: 10.1109/iembs.2006.260259.Peer-Reviewed Original ResearchConceptsRaman signalEarly-stage cancer screeningCancer-related proteasesIntrinsic Raman signalsHigh reaction specificityEarly cancer diagnosisRaman spectral signalsSERS probeSerine protease presentProstate cancer markerSensitive detectionCancer cell identificationOptical probeSitu detectionNanocrescentsCancer markersReaction volumeHigh specificityTAG moleculesPSA concentrationDynamic detectionPSA proteinRadioactive probesProtease enzymeNanoprobe
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