2010
Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate
Wisnewski AV, Liu J, Redlich CA. Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate. Analytical Biochemistry 2010, 400: 251-258. PMID: 20123080, PMCID: PMC3106273, DOI: 10.1016/j.ab.2010.01.037.Peer-Reviewed Original ResearchConceptsHigh-performance liquid chromatographyDiphenylmethane diisocyanateConjugation sitesReaction productsCross-linking agentTandem mass spectrometryPolyurethane productionMass spectrometryMDI-exposed workersCause of asthmaHuman albuminSerum immunoglobulin GLiquid chromatographyReaction specificityDiisocyanateSecond lysineMDI conjugationAirway inflammationAnalytical methodSelf proteinsProteomic methodologiesEpitope specificityAntigenic changesClinical researchConjugates
2007
Peptide-Nanoparticle Hybrid SERS Probes for Optical Detection of Protease Activity
Liu GL, Rosa-Bauza YT, Salisbury CM, Craik C, Ellman JA, Chen FF, Lee LP. Peptide-Nanoparticle Hybrid SERS Probes for Optical Detection of Protease Activity. Journal Of Nanoscience And Nanotechnology 2007, 7: 2323-2330. PMID: 17663247, DOI: 10.1166/jnn.2007.444.Peer-Reviewed Original ResearchMeSH KeywordsCrystallizationEnzyme ActivationHumansMacromolecular SubstancesMaleMaterials TestingMolecular ConformationMolecular Probe TechniquesNanostructuresNanotechnologyOptics and PhotonicsParticle SizePeptide HydrolasesPeptidesProstate-Specific AntigenSensitivity and SpecificitySpectrum Analysis, RamanSurface PropertiesConceptsEarly-stage cancer screeningBackground Raman signalsHigh reaction specificityTAG moleculesIndividual nanoparticlesRaman spectral signalsSERS probeSerine protease presentProstate cancer markerMicrofluidic deviceOptical detectionRaman signalOptical probeSitu detectionPSA moleculesCancer markersReaction volumeReaction specificityMoleculesPeptide cleavageProstate-specific antigenRadioactive probesNanoparticlesNanoprobeConcept study
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