Experience of Advate rAHF-PFM in previously untreated patients and minimally treated patients with haemophilia A
Auerswald G, Thompson A, Recht M, Brown D, Liesner R, Guzmán-Becerra N, Dyck-Jones J, Ewenstein B, Abbuehl B. Experience of Advate rAHF-PFM in previously untreated patients and minimally treated patients with haemophilia A. Thrombosis And Haemostasis 2012, 107: 1072-1082. PMID: 22476554, PMCID: PMC6292131, DOI: 10.1160/th11-09-0642.Peer-Reviewed Original ResearchMeSH KeywordsAntibodiesDrug Administration ScheduleEthnicityEuropeFactor VIIIFemaleHemophilia AHemorrhageHemostasisHemostaticsHumansInfantInfant, NewbornLinear ModelsLogistic ModelsMaleNorth AmericaOdds RatioProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeConceptsMinimally treated patientsFamily history of inhibitorsHistory of inhibitorsRAHF-PFMBleeding episodesNon-Caucasian ethnicityUntreated patientsHaemostatic efficacyHemophilia AAdverse eventsHigh risk of inhibitor developmentFamily historySevere/moderately severe hemophilia ARisk of inhibitor developmentTreat bleeding episodesSevere hemophilia AAssociated with higher riskSevere hemophilia A.Prophylactic treatment regimensExposure daysInhibitor developmentPerioperative coverageRating surgeriesProspective trialsTreatment regimens
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