Leveraging Alzheimer’s Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma
Tolosa-Tort P, DeWan A. Leveraging Alzheimer’s Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma. Molecular Neurobiology 2025, 1-10. PMID: 40411683, DOI: 10.1007/s12035-025-05074-2.Peer-Reviewed Original ResearchPrimary open-angle glaucomaOpen-angle glaucomaOpen-angle glaucoma riskPrimary open-angle glaucoma riskIntraocular pressure controlGene expressionGenome-wide association studiesAlzheimer's diseasePOAG riskGlaucoma riskIrreversible blindnessCurrent therapiesGlaucomaTreatment strategiesMultivariate analysisPathogenic mechanismsEvidence of pleiotropyPressure controlNeuronal repairPrioritized genesBrain cortexAssociation studiesEarly detectionNeuroprotective pathwaysDiseaseChildhood or adolescent abuse and primary open-angle glaucoma in a longitudinal cohort of women
Yu M, Hwang H, Roberts A, Koenen K, Wiggs J, Pasquale L, Kang J. Childhood or adolescent abuse and primary open-angle glaucoma in a longitudinal cohort of women. Eye 2025, 39: 1975-1982. PMID: 40211014, DOI: 10.1038/s41433-025-03785-3.Peer-Reviewed Original ResearchConceptsPrimary open-angle glaucomaPOAG subtypesAssociated with primary open-angle glaucomaOpen-angle glaucomaPrimary open-angle glaucoma casesHazard ratioPrimary open-angle glaucoma riskHigh riskMultivariable-adjusted Cox proportional hazards modelsSignificant dose-response relationshipNurses' Health Study IILongitudinal cohort of womenCox proportional hazards modelsCohort of womenConfidence intervalsMedical record reviewDose-response relationshipEstimate hazard ratiosProportional hazards modelAdverse associationEye examAdverse experience dataGlaucomaRecord reviewAbuse history
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