Leveraging Alzheimer’s Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma
Tolosa-Tort P, DeWan A. Leveraging Alzheimer’s Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma. Molecular Neurobiology 2025, 62: 12488-12497. PMID: 40411683, DOI: 10.1007/s12035-025-05074-2.Peer-Reviewed Original ResearchPrimary open-angle glaucomaOpen-angle glaucomaOpen-angle glaucoma riskPrimary open-angle glaucoma riskIntraocular pressure controlGene expressionGenome-wide association studiesAlzheimer's diseasePOAG riskGlaucoma riskIrreversible blindnessCurrent therapiesGlaucomaTreatment strategiesMultivariate analysisPathogenic mechanismsEvidence of pleiotropyPressure controlNeuronal repairPrioritized genesBrain cortexAssociation studiesEarly detectionNeuroprotective pathwaysDisease
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