2024
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy.
Choudhury A, Cady M, Lucas C, Najem H, Phillips J, Palikuqi B, Zakimi N, Joseph T, Birrueta J, Chen W, Oberheim Bush N, Hervey-Jumper S, Klein O, Toedebusch C, Horbinski C, Magill S, Bhaduri A, Perry A, Dickinson P, Heimberger A, Ashworth A, Crouch E, Raleigh D. Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy. Cancer Discovery 2024, 14: 1823-1837. PMID: 38742767, PMCID: PMC11452293, DOI: 10.1158/2159-8290.cd-23-1459.Peer-Reviewed Original ResearchConceptsResistance to radiotherapyMeningioma tumorigenesisSystemic therapyTreating meningiomasStem cellsGenetically engineered mouse modelsTumor-initiating capacityHigh-grade meningiomasReduced tumor growthPrimary intracranial tumorsMeningioma growthImproved survivalIntracranial tumorsRadiotherapyTherapeutic vulnerabilitiesTumor growthMeningiomasMouse modelSingle-cell transcriptomicsLineage tracingNotch3TumorigenesisCell proliferationReduced survivalCell types
2023
Frailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology
Qureshi H, Tabor J, Pickens K, Lei H, Vasandani S, Jalal M, Vetsa S, Elsamadicy A, Marianayagam N, Theriault B, Fulbright R, Qin R, Yan J, Jin L, O’Brien J, Morales-Valero S, Moliterno J. Frailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology. Journal Of Neuro-Oncology 2023, 164: 299-308. PMID: 37624530, PMCID: PMC10522517, DOI: 10.1007/s11060-023-04416-1.Peer-Reviewed Original ResearchBrain tumor patientsTumor patientsPostoperative outcomesFrailty indexSystematic reviewBrain tumorsPrimary intracranial tumorsMethodsSystematic literature reviewPrognostic valueVestibular schwannomaPostsurgical outcomesBenign tumorsIntracranial tumorsLesion etiologyTumor outcomeExclusion criteriaMalignant lesionsPRISMA guidelinesPatientsConclusionOur reviewTumor pathologyUnique etiologyTumor typesFrailtyNeurosurgical oncology
2022
CSIG-36. NOTCH3 DRIVES MENINGIOMA TUMORIGENESIS AND RESISTANCE TO RADIOTHERAPY
Cady M, Choudhury A, Lucas C, Phillips J, Palikuqi B, Bush N, Klein O, Hervey-Jumper S, Dickinson P, Magill S, Bhaduri A, Crouch E, Raleigh D. CSIG-36. NOTCH3 DRIVES MENINGIOMA TUMORIGENESIS AND RESISTANCE TO RADIOTHERAPY. Neuro-Oncology 2022, 24: vii47-vii47. PMCID: PMC9661124, DOI: 10.1093/neuonc/noac209.185.Peer-Reviewed Original ResearchCancer stem cell genesStem cell genesSingle-cell RNA sequencingTumor-initiating capacity in vivoXenograft growthNotch3 expressionHuman meningiomasMeningioma cellsCell genesClonogenic growth in vitroExpression of cancer stem cell genesRNA sequencingCell typesExtended survival benefitResponse to radiotherapyProlonged overall survivalRadiotherapy in vivoCell-extrinsic mechanismsCopy number variant analysisPrimary intracranial tumorsPerivascular stem cell nicheExpression of Notch3Deconvolution of cell typesHuman meningioma cellsStem cell niche
2021
STEM-27. A PERIVASCULAR STEM CELL UNDERLIES VERTEBRATE MENINGEAL TUMORIGENESIS
Choudhury A, Cady M, Lucas C, Palikuqi B, Klein O, Hervey-Jumper S, Phillips J, Dickinson P, Magill S, Bhaduri A, Crouch E, Raleigh D. STEM-27. A PERIVASCULAR STEM CELL UNDERLIES VERTEBRATE MENINGEAL TUMORIGENESIS. Neuro-Oncology 2021, 23: vi26-vi27. DOI: 10.1093/neuonc/noab196.101.Peer-Reviewed Original ResearchHuman meningiomasBackground MeningiomasStem cellsGenetically engineered mouse modelsCancer stem cell genesClonogenic growth in vitroRNA sequencingDecreased overall survivalStem cell approachesPrimary intracranial tumorsPerivascular stem cell nicheExpression of Notch3Stem cell genesCell typesCopy number variants identificationTumor growth in vivoNon-tumor cellsStem cell nicheGrowth in vivoGrowth in vitroOverall survivalPerivascular stem cellsIntracranial tumorsTumor cellsMeningiomasA molecularly integrated grade for meningioma
Driver J, Hoffman SE, Tavakol S, Woodward E, Maury EA, Bhave V, Greenwald NF, Nassiri F, Aldape K, Zadeh G, Choudhury A, Vasudevan HN, Magill ST, Raleigh DR, Abedalthagafi M, Aizer AA, Alexander BM, Ligon KL, Reardon DA, Wen PY, Al-Mefty O, Ligon AH, Dubuc AM, Beroukhim R, Claus EB, Dunn IF, Santagata S, Bi W. A molecularly integrated grade for meningioma. Neuro-Oncology 2021, 24: 796-808. PMID: 34508644, PMCID: PMC9071299, DOI: 10.1093/neuonc/noab213.Peer-Reviewed Original ResearchConceptsMeningioma patientsWHO gradeGrading systemCommon primary intracranial tumorWorld Health Organization gradeProgression-free survivalAdditional prognostic informationPrimary intracranial tumorsCox proportional hazardsGrading schemeTime-dependent areaSurgical resectionChromosomal copy-number dataClinical behaviorHistopathology featuresPrognostic informationPatient managementIntracranial tumorsDiscovery cohortClinical careIndependent cohortMitotic countPatientsProportional hazardsMeningiomas
1983
Intracranial Adenocystic Carcinoma Presenting as a Primary Brain Tumor.
Piepmeier J, Virapongse C, Kier L, Kim J, Greenberg A. Intracranial Adenocystic Carcinoma Presenting as a Primary Brain Tumor. Neurosurgery 1983, 12: 348. DOI: 10.1097/00006123-198303000-00021.Peer-Reviewed Original ResearchIntracranial Adenocystic Carcinoma Presenting as a Primary Brain Tumor
Piepmeier J, Virapongse C, Kier L, Kim J, Greenberg A. Intracranial Adenocystic Carcinoma Presenting as a Primary Brain Tumor. Neurosurgery 1983, 12: 348-352. PMID: 6302554, DOI: 10.1227/00006123-198303000-00021.Peer-Reviewed Original Research
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