Tissue‐engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel
Hibino N, Villalona G, Pietris N, Duncan DR, Schoffner A, Roh JD, Yi T, Dobrucki LW, Mejias D, Sawh‐Martinez R, Harrington JK, Sinusas A, Krause DS, Kyriakides T, Saltzman WM, Pober JS, Shin'oka T, Breuer CK. Tissue‐engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel. The FASEB Journal 2011, 25: 2731-2739. PMID: 21566209, PMCID: PMC3136337, DOI: 10.1096/fj.11-182246.Peer-Reviewed Original ResearchConceptsBone marrow-derived mononuclear cellsSmooth muscle cellsAutologous bone marrow-derived mononuclear cellsMarrow-derived mononuclear cellsMuscle cellsAnalogous mouse modelsAdjacent blood vesselsHuman bone marrow-derived mononuclear cellsMononuclear cellsClinical trialsMouse recipientsImmunodeficient miceComposite graftMouse modelBone marrowMacrophage invasionCell originChimeric hostGraftBlood vesselsHost cell originHost macrophagesNeovessel formationVessel wallNeovesselsVascular tissue engineering: Towards the next generation vascular grafts
Naito Y, Shinoka T, Duncan D, Hibino N, Solomon D, Cleary M, Rathore A, Fein C, Church S, Breuer C. Vascular tissue engineering: Towards the next generation vascular grafts. Advanced Drug Delivery Reviews 2011, 63: 312-323. PMID: 21421015, DOI: 10.1016/j.addr.2011.03.001.Peer-Reviewed Original ResearchConceptsBone marrow-derived mononuclear cellsClinical trialsAutologous bone marrow-derived mononuclear cellsNext-generation vascular graftsMarrow-derived mononuclear cellsVascular graftsExcellent safety profileFirst clinical trialRisk of infectionBiodegradable tubular scaffoldsTissue engineering technologyPrimary graftSafety profileMononuclear cellsCardiovascular diseaseTubular scaffoldsCardiovascular surgeryGraftSynthetic vascular graftsVascular neotissue formationNeotissue formationContinued investigationTEVGsEngineering technologyTrials
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply