2025
Elevated ctDNA Tumor Fraction Is Associated with Improved Mutation Detection but Worse Overall Survival in Advanced Non-Small Cell Lung Cancer: a Lung-MAP Study.
Mack P, Redman M, Tukachinsky H, Kozono D, Minichiello K, Dragnev K, Tolba K, Neal J, Madison R, Waqar S, Aggarwal C, Hirsch F, Patel J, Herbst R, Chiang A, Reckamp K, Kelly K, Borghaei H, Gray J, Gandara D. Elevated ctDNA Tumor Fraction Is Associated with Improved Mutation Detection but Worse Overall Survival in Advanced Non-Small Cell Lung Cancer: a Lung-MAP Study. Clinical Cancer Research 2025 PMID: 40465842, DOI: 10.1158/1078-0432.ccr-24-3658.Peer-Reviewed Original ResearchCirculating tumor DNAPositive percent agreementOverall survivalTumor fractionAdvanced NSCLCMutation detectionAdvanced non-small cell lung cancerAssociated with significantly worse overall survivalMaximum somatic allele frequencyNon-small cell lung cancerSignificantly worse overall survivalTF levelsCopy number gainCell lung cancerPaired tumor tissuesPatient overall survivalVariant allele frequencyMutational concordanceTumor aneuploidyAllele frequenciesFoundation MedicineTumor DNAClinical outcomesPlasma levelsLung cancerQuantifying the clinical impact of tissue reflex testing for liquid biopsy ESR1 mutation–negative cases with low ctDNA tumor fraction (TF) in HR(+)HER2(-) breast cancer.
Du J, Quintanilha J, Huang R, Heilmann A, Kahn A, Rozenblit M, Chiang A, Pusztai L, Krop I, Winer E, Graf R, Mills J, Gasco Hernandez A, Levy M, Lustberg M. Quantifying the clinical impact of tissue reflex testing for liquid biopsy ESR1 mutation–negative cases with low ctDNA tumor fraction (TF) in HR(+)HER2(-) breast cancer. Journal Of Clinical Oncology 2025, 43: 1065-1065. DOI: 10.1200/jco.2025.43.16_suppl.1065.Peer-Reviewed Original ResearchMetastatic breast cancerComprehensive genomic profilingPositive percent agreementClinicogenomic databaseTumor fractionCtDNA sheddingBC patientsReflex testBreast cancerFirst-line standard of careResistance to estrogen deprivationTissue comprehensive genomic profilingMetastatic breast cancer patientsFalse negative rateFoundationOne Liquid CDxFirst-line standardMutation-negative casesCohort of patientsStandard of careESR1 mutationsTumor genotypeEstrogen deprivationFirst-lineAromatase inhibitorsClinical impact
2024
Self-Reported Methamphetamine Use Versus Biological Testing Among Treatment-Seeking Patients
Gholami J, Ardeshir M, Rostam-Abadi Y, Baheshmat S, Shadloo B, Rahimi-Movaghar A. Self-Reported Methamphetamine Use Versus Biological Testing Among Treatment-Seeking Patients. Iranian Journal Of Psychiatry And Behavioral Sciences 2024, 18 DOI: 10.5812/ijpbs-148330.Peer-Reviewed Original ResearchNegative predictive valuePositive percent agreementMethamphetamine use disorderMethamphetamine useTreatment-seeking patientsSelf-reported useCohen's kappa statisticUrine testsUse disorderPercent agreementKappa statisticNo significant factorsCross-sectional studyDrug treatment centersMonitoring treatmentPredictive valueMethamphetaminePatientsImmunoassay techniqueTreatment-seekingTreatment centersUrinalysisUrineAddiction studiesTreatmentPerformance of two modified two-tier algorithms for the serologic diagnosis of Lyme disease
Landry M, Hassan S, Rottmann B, Pesak S, Ordazzo M, Skrzyniarz M, Deponte S, Peaper D. Performance of two modified two-tier algorithms for the serologic diagnosis of Lyme disease. Journal Of Clinical Microbiology 2024, 62: e00139-24. PMID: 38597655, PMCID: PMC11077974, DOI: 10.1128/jcm.00139-24.Peer-Reviewed Original ResearchConceptsPositive percent agreementSerologic diagnosis of Lyme diseaseDiagnosis of Lyme diseaseEnzyme-linked immunoassayBorrelia speciesTwo-tier algorithmLyme diseaseTwo-tier testImmunoblottingLaboratory diagnosis of Lyme diseaseLIAISON chemiluminescent immunoassaysChemiluminescence immunoassayDetection of IgMScreening testConsensus reference standardSerological diagnosisLaboratory diagnosisDiaSorinIgM resultsIgM detectionLiquid biopsy‐based circulating tumour (ct)DNA analysis of a spectrum of myeloid and lymphoid malignancies yields clinically actionable results
Mata D, Lee J, Shanmugam V, Marcus C, Schrock A, Williams E, Ritterhouse L, Hickman R, Janovitz T, Patel N, Kroger B, Ross J, Mirza K, Oxnard G, Vergilio J, Elvin J, Benhamida J, Decker B, Xu M. Liquid biopsy‐based circulating tumour (ct)DNA analysis of a spectrum of myeloid and lymphoid malignancies yields clinically actionable results. Histopathology 2024, 84: 1224-1237. PMID: 38422618, DOI: 10.1111/his.15168.Peer-Reviewed Original ResearchConceptsNon-Hodgkin's lymphomaPlasma-cell neoplasmsAcute myeloid leukemiaCirculating tumor DNAHodgkin lymphomaMyelodysplastic syndromeHaematopoietic neoplasmsNext-generation sequencingTissue-based NGSMaximum somatic allele frequencyFoundationOne Liquid CDxTherapy-resistant clonesRelevant genomic alterationsPositive percent agreementPotential clinical utilityLymphoid malignanciesTumor DNAMyeloid leukemiaPlasma-cellsTissue biopsiesGenomic alterationsPathogenic alterationsLiquid biopsyMolecular profilingTP53
2021
Comparison of self-reported substance use with biological testing among treatment-seeking patients with opioid use disorder
Shadloo B, Baheshmat S, Rostam-Abadi Y, Shakeri A, Gholami J, Rahimi-Movaghar A. Comparison of self-reported substance use with biological testing among treatment-seeking patients with opioid use disorder. Journal Of Substance Use And Addiction Treatment 2021, 134: 108555. PMID: 34210569, DOI: 10.1016/j.jsat.2021.108555.Peer-Reviewed Original ResearchConceptsOpioid use disorderSelf-reported opioid useOpioid usePositive percent agreementUrine testsTreatment-seeking patientsCohen's kappa statisticPercent agreementUse disorderKappa statisticNegative predictive valueLonger treatment durationMonitoring treatment adherenceRandom urine testingResults of urinalysisValidity of self-reported drug useCross-sectional studySelf-reported substance useSelf-reported drug useTreatment durationOpioidPredictive valuePatientsTreatment adherenceDrug use
2020
Sequential screening for depression in humanitarian emergencies: a validation study of the Patient Health Questionnaire among Syrian refugees
Poole D, Liao S, Larson E, Hedt-Gauthier B, Raymond N, Bärnighausen T, Smith Fawzi M. Sequential screening for depression in humanitarian emergencies: a validation study of the Patient Health Questionnaire among Syrian refugees. Annals Of General Psychiatry 2020, 19: 5. PMID: 32042301, PMCID: PMC6998825, DOI: 10.1186/s12991-020-0259-x.Peer-Reviewed Original ResearchSequential screening processPatient Health QuestionnairePHQ-2PHQ-8Health QuestionnaireSequential screening approachEight-item Patient Health QuestionnaireScreening processResponse burdenMethodsThis study analyzed dataPercent agreementMental health surveillanceHumanitarian emergenciesNegative percent agreementCross-sectional surveyStudy analyzed dataHealth surveillancePositive percent agreementSymptoms of MDDConclusionsThe benefitsSequential screeningSyrian refugeesValidation studyDepressive disorderRespondents
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